Based on the film design theory, we design anti-reflective coating for short and medium infrared based on chalcogenide glass. Based on calculation and analysis of material thermal stress, a mixed material M-11 is developed as the connecting layer, the parameters of the deposition process are optimized. and the coating structure is corrected based on its mechanical properties. We solve the problem of stripping of chalcogenide glass. The results of spectral tests show that the transmittance in the bands of 1.4-2.5 μm and 3.5-4.5 μm are 95.8% and 96.7%, respectively, which satisfies the requirement of infrared imaging system.