[2] [2] BCK M, YURDAGUL A JR, TABAS I, et al. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities [J]. Nat Rev Cardiol, 2019, 16(7): 389-406.

[3] [3] BNI-SCHNETZLER M, MEIER DT. Islet inflammation in type 2 diabetes [J]. Semin Immunopathol, 2019, 41(4): 501-513.

[4] [4] MCCULLY KS. Homocysteine and vascular disease [J]. Nat Med, 1996, 2(4): 386-389.

[5] [5] STEED MM, TYAGI SC. Mechanisms of cardiovascular remodeling in hyperhomocysteinemia [J]. Antioxid Redox Signal, 2011, 15(7): 1927-1943.

[6] [6] RAINS JL, JAIN SK. Oxidative stress, insulin signaling, and diabetes [J]. Free Radic Biol Med, 2011, 50(5): 567-575.

[11] [11] PEPPARD PE, YOUNG T, PALTA M, et al. Prospective study of the association between sleep-disordered breathing and hypertension[J]. N Engl J Med, 2000, 342(19): 1378-1384.

[12] [12] REICHMUTH KJ, AUSTIN D, SKATRUD JB, et al. Association of sleep apnea and type Ⅱ diabetes: a population-based study [J]. Am J Respir Crit Care Med, 2005, 172(12): 1590-1595.

[13] [13] GUNNARSSON SI, PEPPARD PE, KORCARZ CE, et al. Obstructive sleep apnea is associated with future subclinical carotid artery disease: thirteen-year follow-up from the Wisconsin sleep cohort [J]. Arterioscler Thromb Vasc Biol, 2014, 34(10): 2338-2342.

[14] [14] OLIVEIRA IO, SILVA LP, BORGES MC, et al. Interactions between lifestyle and MTHFR polymorphisms on homocysteine concentrations in young adults belonging to the 1982 Pelotas Birth Cohort [J]. Eur J Clin Nutr, 2017, 71(2): 259-266.

[15] [15] BOUZIDI N, HASSINE M, FODHA H, et al. Association of the methylene-tetrahydrofolate reductase gene rs1801133 C677T variant with serum homocysteine levels, and the severity of coronary artery disease[J]. Sci Rep, 2020, 10(1): 10064. DOI: 10.1038/s41598-020-66937-3.

[16] [16] XIANG T, XIANG H, YAN M, et al. Systemic risk factors correlated with hyperhomocysteinemia for specificMTHFR C677Tgenotypes and sex in the Chinese population [J]. Ann Transl Med, 2020, 8(21): 1455. DOI: 10.21037/atm-20-6587.

[17] [17] MCCULLY KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis [J]. Am J Pathol, 1969, 56(1): 111-128.

[18] [18] NAJIB S, SNCHEZ-MARGALET V. Homocysteine thiolactone inhibits insulin signaling, and glutathione has a protective effect[J]. J Mol Endocrinol, 2001, 27(1): 85-91.

[19] [19] EGUCHI K, NAGAI R. Islet inflammation in type 2 diabetes and physiology[J]. J Clin Invest, 2017, 127(1): 14-23.

[20] [20] XIE X, ZHANG Z, WANG X, et al. Stachydrine protects eNOS uncoupling and ameliorates endothelial dysfunction induced by homocysteine [J]. Mol Med, 2018, 24(1): 10. DOI: 10.1186/s10020-018-0010-0.

[21] [21] STHLINGER MC, TSAO PS, HER JH, et al. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine [J]. Circulation, 2001, 104(21): 2569-2575.

[22] [22] PUSHPAKUMAR S, KUNDU S, SEN U. Endothelial dysfunction: the link between homocysteine and hydrogen sulfide [J]. Curr Med Chem, 2014, 21(32): 3662-3672.

[23] [23] CHAUDHARY P, PANDEY A, AZAD CS, et al. Association of oxidative stress and endothelial dysfunction in hypertension[J]. Anal Biochem, 2020, 590: 113535. DOI: 10.1016/j.ab.2019.113535.

[24] [24] LOVE KM, BARRETT EJ, MALIN SK, et al. Diabetes pathogenesis and management: the endothelium comes of age[J]. J Mol Cell Biol, 2021, 13(7): 500-512.

[25] [25] WANG X, FU J, LI Q, et al. Geographical and ethnic distributions of the MTHFR C677T, A1298C and MTRR A66G gene polymorphisms in Chinese populations: a meta-analysis[J]. PLoS One, 2016, 11(4): e0152414. DOI: 10.1371/journal.pone.0152414.