Porosity of Tablets Based on Terahertz Spectroscopy

Fig. 2. Simulated mathematical model showing the relationship between porosity of tablets, mass fractions of different compositions and refractive index

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Fig. 3. Terahertz pulse signals of tablet. (a) Time-domain spectra; (b) frequency-domain spectra

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$(a) Experimental results of refractive index and thickness of tablets in the first group; (b) experimental results of refractive index and porosity of tablets in the second group; (c) experimental results of refractive index and API mass fraction of tablets in the third group$

Fig. 4. (a) Experimental results of refractive index and thickness of tablets in the first group; (b) experimental results of refractive index and porosity of tablets in the second group; (c) experimental results of refractive index and API mass fraction of tablets in the third group

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$Refractive indexes of MCC and API obtained by linear extrapolation when porosity is zero. (a) Refractive indexes of MCC and API obtained by the third group data when the mass fraction of API is 7.1%; (b) refractive indexes of MCC and API when porosity is zero$

Fig. 5. Refractive indexes of MCC and API obtained by linear extrapolation when porosity is zero. (a) Refractive indexes of MCC and API obtained by the third group data when the mass fraction of API is 7.1%; (b) refractive indexes of MCC and API when porosity is zero

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Fig. 6. Calculated and experimental porosities of tablets. (a) The first group; (b) the second group; (c) the third group

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Table 1. Parameters of tablets with different thicknesses in the first group
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Table 1. Parameters of tablets with different thicknesses in the first group
No. m /mg d /mm H /mm x /% $\begin{matrix} {p_{t h eory}}_{} \end{matrix}$ /%
1 360.36 13.0744 1.8780 10 7.0
2 440.40 13.0690 2.2788 10 6.2
3 480.13 13.0670 2.5004 10 6.8
4 520.60 13.0678 2.6952 10 6.3

Table 2. Parameters of tablets with different porosities in the second group

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Table 2. Parameters of tablets with different porosities in the second group

No.	m /mg	d /mm	H /mm	x /%	$\begin{matrix} {p_{t h eory}}_{} \end{matrix}$ /%
1	341.11	13.0556	1.7798	10	6.81
2	355.41	13.0504	1.8604	10	7.04
3	362.35	13.0758	1.8922	10	7.18
4	370.32	13.0544	1.9292	10	6.65
5	376.45	13.0636	1.9490	10	6.20
6	385.35	13.0598	2.0028	10	6.51
7	391.69	13.0576	2.0400	10	6.67

Table 3. Parameters of tablets with different API mass fractions in the third group

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Table 3. Parameters of tablets with different API mass fractions in the third group

No.	m /mg	d /mm	H /mm	x /%	$\begin{matrix} {p_{t h eory}}_{} \end{matrix}$ /%
1	401.31	13.0778	2.073	0	7.5
2	400.48	13.0670	2.081	5	7.2
3	400.00	13.0652	2.087	10	6.9
4	401.11	13.0638	2.113	15	7.2
5	400.19	13.0714	2.107	20	6.6
6	399.95	13.0734	2.124	25	6.8
7	399.81	13.0898	2.138	30	7.1
8	400.34	13.0828	2.156	35	7.1

Table 4. Theoretical and experimental changes of refractive index obtained by changing porosity and API mass fraction respectively
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Table 4. Theoretical and experimental changes of refractive index obtained by changing porosity and API mass fraction respectively
Item Δn_eff
Δp=1% Δx=35%
Theoretical change 0.0081 0.0301
Experimental change 0.0152 0.0298

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Huibin Lai, Mingxia He, Tian Tian, Longling Sun. Porosity of Tablets Based on Terahertz Spectroscopy[J]. Acta Optica Sinica, 2018, 38(6): 0630001

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Paper Information

Category: Spectroscopy

Received: Dec. 26, 2017

Accepted: --

Published Online: Jul. 9, 2018

The Author Email: He Mingxia (hhmmxx@tju.edu.cn)

DOI:10.3788/AOS201838.0630001

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Parameters of tablets with different thicknesses in the first group

Table 1. Parameters of tablets with different thicknesses in the first group

Table 2. Parameters of tablets with different porosities in the second group

Table 2. Parameters of tablets with different porosities in the second group

Table 3. Parameters of tablets with different API mass fractions in the third group

Table 3. Parameters of tablets with different API mass fractions in the third group

Table 4. Theoretical and experimental changes of refractive index obtained by changing porosity and API mass fraction respectively

Table 4. Theoretical and experimental changes of refractive index obtained by changing porosity and API mass fraction respectively