Acta Laser Biology Sinica, Volume. 34, Issue 1, 18(2025)

The Role and Research Progress of the Liver Cancer Triple Test and Golgi Protein 73 in Early Liver Cancer Screening

WANG Cong1, TANG Zihua2, YAO Hongbing3, XIANG Zhen2、*, and ZHOU Yali4
Author Affiliations
  • 1School of Humanities and Management, Guilin Medical College, Guilin 541100, China
  • 2Health Examination Center, Affiliated Hospital of Guilin Medical College, Guilin 541001, China
  • 3The Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital of Guilin Medical College, Guilin 541100, China
  • 4School of Basic Medical Sciences, Guilin Medical University, Guilin 541004, China
  • show less
    References(18)

    [1] [1] BRAY F, LAVERSANNE M, SUNG H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA: A Cancer Journal for Clinicians, 2024, 74(3): 229-263.

    [4] [4] MEHTA N, KOTWANI P, NORMAN J, et al. AFP-L3 and DCP are superior to AFP in predicting waitlist dropout in HCC patients: results of a prospective study[J]. Liver Transplantation, 2023, 29(10): 1041-1049.

    [5] [5] PANG B, LENG Y, WANG X, et al. A meta-analysis and of clinical values of 11 blood biomarkers, such as AFP, DCP, and GP73 for diagnosis of hepatocellular carcinoma[J]. Annals of Medicine, 2023, 55(1): 42-61.

    [6] [6] HANIF H, ALI M J, SUSHEELA A T, et al. Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma[J]. World Journal of Gastroenterology, 2022, 28(2): 216-229.

    [7] [7] MOHAMMED A F, XU C, CHENGBIN L I. Clinical utility of biomarkers of hepatocellular carcinoma[J]. Bratislava Medical Journal, 2024, 125(2): 102-106.

    [8] [8] LI H, LIU H, YAN L J, et al. Performance of GALAD score and serum biomarkers for detecting NAFLD-related HCC: a systematic review and network meta-analysis[J]. Expert Review of Gastroenterology & Hepatology, 2023, 17(11): 1159-1167.

    [9] [9] LI B, LIU A, WEN Y, et al. The prognostic values of serum markers in hepatocellular carcinoma after invasive therapies based on real‐world data[J]. Journal of Clinical Laboratory Analysis, 2021, 35(9): e23932.

    [15] [15] FANG Y S, WU Q, ZHAO H C, et al. Do combined assays of serum AFP, AFP-L3, DCP, GP73, and DKK-1 efficiently improve the clinical values of biomarkers in decision-making for hepatocellular carcinoma? A meta-analysis[J]. Expert Review of Gastroenterology & Hepatology, 2021, 15(9): 1065-1076.

    [18] [18] NORMAN J S, LI P J, KOTWANI P, et al. AFP-L3 and DCP strongly predict early hepatocellular carcinoma recurrence after liver transplantation[J]. Journal of Hepatology, 2023, 79(6): 1469-1477.

    [19] [19] TAYOB N, KANWAL F, ALSARRAJ A, et al. The performance of AFP, AFP-3, DCP as biomarkers for detection of hepatocellular carcinoma (HCC): a phase 3 biomarker study in the United States[J]. Clinical Gastroenterology and Hepatology, 2023, 21(2): 415-423.

    [20] [20] BURCIU C, ȘIRLI R, BENDE R, et al. A statistical approach to the diagnosis and prediction of HCC using CK19 and Glypican 3 biomarkers[J]. Diagnostics, 2023, 13(7): 1253.

    [21] [21] HUAN L. Efficacy analysis of combined detection of 5 serological tumor markers including MIF and PIVKA-II for early diagnosis of primary hepatic cancer[J]. Pakistan Journal of Medical Sciences, 2021, 37(5): 1456-1460.

    [22] [22] SCHOTTEN C, OSTERTAG B, SOWA J P, et al. GALAD score detects early-stage hepatocellular carcinoma in a european cohort of chronic hepatitis B and C patients[J]. Pharmaceuticals, 2021, 14(8): 735.

    [24] [24] CHEN P, SONG H, XU W, et al. Validation of the GALAD model and establishment of a new model for HCC detection in Chinese patients[J]. Frontiers in Oncology, 2022, 12: 1037742.

    [25] [25] PIRATVISUTH T, TANWANDEE T, THONGSAWAT S, et al. Multimarker panels for detection of early stage hepatocellular carcinoma: a prospective, multicenter, case-control study[J]. Hepatology Communications, 2022, 6(4): 679-691.

    [31] [31] OLBRICH A, NIEMEYER J, SEIFFERT H, et al. The GALAD score and the BALAD-2 score correlate with transarterial and systemic treatment response and survival in patients with hepatocellular carcinoma[J]. Journal of Cancer Research and Clinical Oncology, 2024, 150(2): 81.

    [32] [32] JITPRAPHAWAN O, RUAMTAWEE W, TREEWATCHAREEKORN M, et al. Diagnostic and prognostic performances of GALAD score in staging and 1-year mortality of hepatocellular carcinoma: a prospective study[J]. World Journal of Gastroenterology, 2024, 30(17): 2343-2353.

    [40] [40] BANJAN B, VISHWAKARMA R, RAMAKRISHNAN K, et al. Targeting AFP-RAR complex formation: a potential strategy for treating AFP-positive hepatocellular carcinoma[J]. Molecular Diversity, 2024. https://doi.org/10.1007/s11030-024-10915-8.

    Tools

    Get Citation

    Copy Citation Text

    WANG Cong, TANG Zihua, YAO Hongbing, XIANG Zhen, ZHOU Yali. The Role and Research Progress of the Liver Cancer Triple Test and Golgi Protein 73 in Early Liver Cancer Screening[J]. Acta Laser Biology Sinica, 2025, 34(1): 18

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category:

    Received: Aug. 9, 2024

    Accepted: Mar. 21, 2025

    Published Online: Mar. 21, 2025

    The Author Email: XIANG Zhen (ybyyyjkgl@163.com)

    DOI:10.3969/j.issn.1007-7146.2025.01.003

    Topics