Effects of Indocyanine Green and Methylene Blue on Tensile Strength and Thermal Damage of Laser Biological Tissue Soldering

Fig. 1. Experimental instrument and sample. (a) Laser for biological tissue welding and thermal imager; (b) skin sample in vitro and welding position

Download full size

Fig. 2. Test instrument and test processing. (a) Digital explicit push-pull force meter for measuring tensile strength; (b) diagram of process for measuring tensile strength

Download full size

Fig. 3. Macroscopic morphologies of welded specimens of methylene blue test group. (a) Front of welded incision; (b) reverse side of welded incision; (c) side of welded incision

Download full size

Fig. 4. Macroscopic morphologies of welded specimens of indocyanine green test group. (a) Front of welded incision; (b) reverse side of welded incision; (c) side of welded incision

Download full size

Fig. 5. Average tensile strength of welded incisions with different biological dyes

Download full size

Fig. 6. Maximum tensile strength of welded incisions with different biological dyes

Download full size

Fig. 7. Effects of methylene blue concentration and applied position on tensile strength

Download full size

Fig. 8. Effects of indocyanine green concentration and applied position on tensile strength

Download full size

Fig. 9. Average temperature of measuring points of different dyes at different applied positions

Download full size

Table 1. Process parameters of laser welding for biological tissue
View table
Table 1. Process parameters of laser welding for biological tissue
Power /W Pulsefrequency /kHz Weldingspeed /(mm·s^-1) Weldingtime /s
4 100 100 1200

Table 2. Type, mass concentration, and location distribution of dyes
View table
Table 2. Type, mass concentration, and location distribution of dyes
Type of dyes Mass concentration /(mg·L^-1)
Surface Back
50 50
100 100
Indocyanine green 150 150
200 200
250 250
50 50
100 100
Methylene blue 150 150
200 200
250 250

Table 3. Tensile strength of methylene blue test group

View table

Table 3. Tensile strength of methylene blue test group

Mass concentration of methylene blue /(mg·L^-1)	Tensile strength /(N·cm^-2)
Mass concentration of methylene blue /(mg·L^-1)	Surface	Back
50	14.93±1.22	8.08±0.89
100	11.10±0.92	10.00±0.93
150	11.73±0.78	9.60±1.30
200	11.20±0.83	7.80±1.62
250	10.60±1.13	6.78±0.91

Table 4. Tensile strength of indocyanine green test group

View table

Table 4. Tensile strength of indocyanine green test group

Mass concentration of indocyanine green /(mg·L^-1)	Tensile strength /(N·cm^-2)
Mass concentration of indocyanine green /(mg·L^-1)	Surface	Back
50	11.18±0.80	8.60±0.91
100	10.88±1.23	8.90±1.06
150	15.15±1.21	9.15±1.30
200	13.00±1.35	11.90±0.66
250	10.93±0.95	9.55±0.90

Table 5. Thermal damage of measuring points of different dyes at different applied positions
View table
Table 5. Thermal damage of measuring points of different dyes at different applied positions
Appliedposition Thermal damage
Controlgroup Methyleneblue Indocyaninegreen
Surface 5881 740 11.7
Back 5881 934 46.9

Tools

Get Citation

Copy Citation Text

Cong Li, Kehong Wang, Jun Huang. Effects of Indocyanine Green and Methylene Blue on Tensile Strength and Thermal Damage of Laser Biological Tissue Soldering[J]. Chinese Journal of Lasers, 2019, 46(12): 1207002

Download Citation

EndNote(RIS)BibTex Plain Text

Set citation alerts for article

Save article for my favorites