International Journal of Extreme Manufacturing, Volume. 7, Issue 3, 35005(2025)

Osteomimetic bioceramic scaffolds with high-fidelity human-bone features produced by rotational printing

Pang Shumin, Wu Dongwei, Hanaor Dorian A H, Haibel Astrid, Kurreck Jens, and Gurlo Aleksander
References(62)

[1] [1] Alonzo M, Primo F A, Kumar S A, Mudloff J A, Dominguez E, Fregoso G, Ortiz N, Weiss W M and Joddar B 2021 Bone tissue engineering techniques, advances, and scaffolds for treatment of bone defectsCurr. Opin. Biomed. Eng.17100248

[2] [2] Chen A N, Su J, Li Y J, Zhang H B, Shi Y S, Yan C Z and Lu J 2023 3D/4D printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineeringInt. J. Extrem. Manuf.5032007

[3] [3] Wu M Y, Zhao M C, Cai Y, Yao J G, Wang P and Atrens A 2024 Recent advances in bio-functional Ta-based bone materials: materials design and bioactivityInt. J. Extrem. Manuf.6062010

[4] [4] Jiang S J, Wang M H and He J C 2021 A review of biomimetic scaffolds for bone regeneration: toward a cell-free strategyBioeng. Transl. Med.6e10206

[5] [5] Fan Z H, Liu H X, Ding Z Z, Xiao L Y, Lu Q and Kaplan D L 2023 Simulation of cortical and cancellous bone to accelerate tissue regenerationAdv. Funct. Mater.332301839

[6] [6] Li Z W, Du T M, Ruan C S and Niu X F 2021 Bioinspired mineralized collagen scaffolds for bone tissue engineeringBioact. Mater.61491–511

[7] [7] Black J D and Tadros B J 2020 Bone structure: from cortical to calciumOrthop. Trauma34113–9

[8] [8] Man K, Brunet M Y, Louth S, Robinson T E, Fernandez-Rhodes M, Williams S, Federici A S, Davies O G, Hoey D A and Cox S C 2021 Development of a bone-mimetic 3D printed Ti6Al4V scaffold to enhance osteoblast-derived extracellular vesicles' therapeutic efficacy for bone regenerationFront. Bioeng. Biotechnol.9757220

[9] [9] Granel H, Bossard C, Collignon A M, Wauquier F, Lesieur J, Rochefort G Y, Jallot E, Lao J and Wittrant Y 2019 Bioactive glass/polycaprolactone hybrid with a dual cortical/trabecular structure for bone regenerationACS Appl. Bio Mater.23473–83

[10] [10] Sun Xet al2022 3D bioprinting of osteon-mimetic scaffolds with hierarchical microchannels for vascularized bone tissue regenerationBiofabrication14035008

[11] [11] Zhang Met al2020 3D printing of Haversian bone-mimicking scaffolds for multicellular delivery in bone regenerationSci. Adv.6eaaz6725

[12] [12] Chadha U, Selvaraj S K, Ravinuthala A K, Maddini Y, Arasu K, Yadav S, Kumari O, Pant S and Paramasivam V 2022 Bioinspired techniques in freeze casting: a survey of processes, current advances, and future directionsInt. J. Polym. Sci.20229169046

[13] [13] Shao G F, Hanaor D A H, Shen X D and Gurlo A 2020 Freeze casting: from low-dimensional building blocks to aligned porous structures-a review of novel materials, methods, and applicationsAdv. Mater.321907176

[14] [14] Henning L M, Zavareh S, Kamm P H, Hner M, Fischer H, Banhart J, Schmidt F and Gurlo A 2017 Manufacturing and characterization of highly porous bioactive glass composite scaffolds using unidirectional freeze castingAdv. Eng. Mater.191700129

[15] [15] Kong L W Y, Zhao Y G, Xiong Y, Chen J L, Wang S, Yan Z M, Shi H B, Liu Z L and Wang X M 2024 Multiscale engineered artificial compact bone via bidirectional freeze-driven lamellated organization of mineralized collagen microfibrilsBioact. Mater.40168–81

[16] [16] Bazrafshan Z and Stylios G K 2019 Spinnability of collagen as a biomimetic material: a reviewInt. J. Biol. Macromol.129693–705

[17] [17] Shi S, Si Y F, Han Y T, Wu T, Iqbal M I, Fei B, Li R K Y, Hu J L and Qu J P 2022 Recent progress in protective membranes fabricated via electrospinning: advanced materials, biomimetic structures, and functional applicationsAdv. Mater.342107938

[18] [18] Zhu Y Z, Joralmon D, Shan W T, Chen Y Y, Rong J H, Zhao H Y, Xiao S Q and Li X J 2021 3D printing biomimetic materials and structures for biomedical applicationsBio-des. Manuf.4405–28

[19] [19] Chen Y Wet al2024 3D printed grafts with gradient structures for organized vascular regenerationInt. J. Extrem. Manuf.635503

[20] [20] Meng Z J, Mu X D, He J K, Zhang J L, Ling R and Li D C 2023 Embedding aligned nanofibrous architectures within 3D-printed polycaprolactone scaffolds for directed cellular infiltration and tissue regenerationInt. J. Extrem. Manuf.50S25001

[21] [21] Wu D W, Yu Y, Tan J W, Huang L, Luo B H, Lu L and Zhou C R 2018 3D bioprinting of gellan gum and poly(ethylene glycol) diacrylate based hydrogels to produce human-scale constructs with high-fidelityMater. Des.160486–95

[22] [22] Wu D Wet al2024 Bioprinting of perfusable vascularized organ models for drug development via sacrificial-free direct ink writingAdv. Funct. Mater.342314171

[23] [23] Pang S M, Wu D W, Yang H T, Kamutzki F, Kurreck J, Gurlo A and Hanaor D A H 2023 Enhanced mechanical performance and bioactivity in strontium/copper co-substituted diopside scaffoldsBiomater. Adv.145213230

[24] [24] Fiume E, Ciavattini S, Vern E and Baino F 2021 Foam replica method in the manufacturing of bioactive glass scaffolds: out-of-date technology or still underexploited potential?Materials142795

[25] [25] Imani S M, Rabiee S M, Goudarzi A M, Dardel M and Tayebi L 2022 Optimization of composite bone scaffolds prepared by a new modified foam replica techniqueMater. Today Commun.31103293

[26] [26] Pang S M, Wu D W, Gurlo A, Kurreck J and Hanaor D A H 2023 Additive manufacturing and performance of bioceramic scaffolds with different hollow strut geometriesBiofabrication15025011

[27] [27] Beheshtizadeh N, Azami M, Abbasi H and Farzin A 2022 Applying extrusion-based 3D printing technique accelerates fabricating complex biphasic calcium phosphate-based scaffolds for bone tissue regenerationJ. Adv. Res.4069–94

[28] [28] Zhi Wet al2022 Optimal regenerative repair of large segmental bone defect in a goat model with osteoinductive calcium phosphate bioceramic implantsBioact. Mater.11240–53

[29] [29] Pang S M, Wu D W, Kamutzki F, Kurreck J, Gurlo A and Hanaor D A H 2022 High performing additively manufactured bone scaffolds based on copper substituted diopsideMater. Des.215110480

[30] [30] Del-mazo-barbara L and Ginebra M P 2021 Rheological characterisation of ceramic inks for 3D direct ink writing: a reviewJ. Eur. Ceram. Soc.4118–33

[31] [31] Wu D W, Pang S M, Rhrs V, Berg J, Ali A S M, Mei Y K, Ziersch M, Tolksdorf B and Kurreck J 2024 Man vs. machine: automated bioink mixing device improves reliability and reproducibility of bioprinting results compared to human operatorsInt. J. Bioprint.101974

[32] [32] Renders G A P, Mulder L, van Ruijven L J and van Eijden T M G J 2007 Porosity of human mandibular condylar boneJ. Anat.210239–48

[33] [33] Kocherova Iet al2019 Human umbilical vein endothelial cells (HUVECs) Co-culture with osteogenic cells: from molecular communication to engineering prevascularised bone graftsJ. Clin. Med.81602

[34] [34] Hoemann C D, El-Gabalawy H and McKee M D 2009In vitroosteogenesis assays: influence of the primary cell source on alkaline phosphatase activity and mineralizationPathol. Biol.57318–23

[35] [35] Wang Y H, Liu Y L, Maye P and Rowe D W 2006 Examination of mineralized nodule formation in living osteoblastic cultures using fluorescent dyesBiotechnol. Prog.221697–701

[36] [36] Saran U, Gemini Piperni S and Chatterjee S 2014 Role of angiogenesis in bone repairArch. Biochem. Biophys.561109–17

[37] [37] Koushik T M, Miller C M and Antunes E 2023 Bone tissue engineering scaffolds: function of multi-material hierarchically structured scaffoldsAdv. Healthcare Mater.122202766

[38] [38] Valtanen R S, Yang Y P, Gurtner G C, Maloney W J and Lowenberg D W 2021 Synthetic and Bone tissue engineering graft substitutes: what is the future?Injury52S72–S77

[39] [39] Cox S C, Thornby J A, Gibbons G J, Williams M A and Mallick K K 2015 3D printing of porous hydroxyapatite scaffolds intended for use in bone tissue engineering applicationsMater. Sci. Eng.C47237–47

[40] [40] Bertol L S, Schabbach R and Loureiro Dos Santos L A 2017 Different post-processing conditions for 3D bioprinted -tricalcium phosphate scaffoldsJ. Mater. Sci., Mater. Med.28168

[41] [41] Roohani-Esfahani S I, Newman P and Zreiqat H 2016 Design and fabrication of 3D printed scaffolds with a mechanical strength comparable to cortical bone to repair large bone defectsSci. Rep.619468

[42] [42] Monfared M H, Ranjbar F E, Torbati M, Ali Poursamar S, Lot fibakhshaiesh N, Ai J, Ebrahimi-Barough S and Azami M 2022 Preparation and characterization of 3D nanocomposite scaffold from bioactive glass/-tricalcium phosphate via Robocasting method for bone tissue engineeringJ. Non-Cryst. Solids593121769

[43] [43] Triyono J, Alfiansyah R, Sukanto H, Ariawan D and Nugroho Y 2020 Fabrication and characterization of porous bone scaffold of bovine hydroxyapatite-glycerin by 3D printing technologyBioprinting18e00078

[44] [44] Goyos-Ball L, Garca-Tun E, Fernndez-Garca E, Daz R, Fernndez A, Prado C, Saiz E and Torrecillas R 2017 Mechanical and biological evaluation of 3D printed 10CeTZP-Al 2 O 3 structuresJ. Eur. Ceram. Soc.373151–8

[45] [45] Chang C H, Lin C Y, Liu F H, Chen M H C, Lin C P, Ho H N and Liao Y S 2015 3D printing bioceramic porous scaffolds with good mechanical property and cell affinityPLoS One10e0143713

[46] [46] Qin H L, Wei Y M, Han J Y, Jiang X J, Yang X Y, Wu Y M, Gou Z R and Chen L L 2022 3D printed bioceramic scaffolds: adjusting pore dimension is beneficial for mandibular bone defects repairJ. Tissue Eng. Regen. Med.16409–21

[47] [47] Ryan E and Yin S 2022 Compressive strength of -TCP scaffolds fabricated via lithography-based manufacturing for bone tissue engineeringCeram. Int.4815516–24

[48] [48] Paredes C, Martnez-Vzquez F J, Elsayed H, Colombo P, Pajares A and Miranda P 2021 Using ductile cores for enhancing the mechanical performance of hollow strut -TCP scaffolds fabricated by digital light processingCeram. Int.4710163–73

[49] [49] Wang Y, Chen S S, Liang H W, Liu Y, Bai J M and Wang M 2022 Digital light processing (DLP) of nano biphasic calcium phosphate bioceramic for making bone tissue engineering scaffoldsCeram. Int.4827681–92

[50] [50] Shao H P, He J Z, Lin T, Zhang Z N, Zhang Y M and Liu S W 2019 3D gel-printing of hydroxyapatite scaffold for bone tissue engineeringCeram. Int.451163–70

[51] [51] Liu S D, Chen J M, Chen T and Zeng Y 2021 Fabrication of trabecular-like beta-tricalcium phosphate biomimetic scaffolds for bone tissue engineeringCeram. Int.4713187–98

[52] [52] Kundu J, Pati F, Shim J H and Cho D W 2014 Rapid prototyping technology for bone regenerationRapid Prototyping of Biomaterialsed R Narayan (Woodhead Publishing) pp 254–84

[53] [53] Savio D and Bagno A 2022 When the total hip replacement fails: a review on the stress-shielding effectProcesses10612

[54] [54] Liverani E, Rogati G, Pagani S, Brogini S, Fortunato A and Caravaggi P 2021 Mechanical interaction between additive-manufactured metal lattice structures and bone in compression: implications for stress shielding of orthopaedic implantsJ. Mech. Behav. Biomed. Mater.121104608

[55] [55] Dong X N, Acuna R L, Luo Q and Wang X D 2012 Orientation dependence of progressive post-yield behavior of human cortical bone in compressionJ. Biomech.452829–34

[56] [56] Koons G L, Diba M and Mikos A G 2020 Materials design for bone-tissue engineeringNat. Rev. Mater.5584–603

[57] [57] Mofakhami S and Salahinejad E 2021 Biphasic calcium phosphate microspheres in biomedical applicationsJ. Control. Release338527–36

[58] [58] de Wildt B W M, Cramer E E A, de Silva L S, Ito K, Gawlitta D and Hofmann S 2023 Evaluating material-driven regeneration in a tissue engineered humanin vitrobone defect modelBone166116597

[59] [59] Mohammadi H, Sepantafar M, Muhamad N and Bakar Sulong A 2021 How does scaffold porosity conduct bone tissue regeneration?Adv. Eng. Mater.232100463

[60] [60] Abbasi N, Hamlet S, Love R M and Nguyen N T 2020 Porous scaffolds for bone regenerationJ. Sci. Adv. Mater. Devices51–9

[61] [61] Yu W, Sun X, Meng H Y, Sun B C, Chen P, Liu X J, Zhang K H, Yang X, Peng J and Lu S B 2017 3D printed porous ceramic scaffolds for bone tissue engineering: a reviewBiomater. Sci.51690–8

[62] [62] Liu M C, Suo S, Wu J, Gan Y X, Hanaor D A H and Chen C Q 2019 Tailoring porous media for controllable capillary flowJ. Colloid Interface Sci.539379–87

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Pang Shumin, Wu Dongwei, Hanaor Dorian A H, Haibel Astrid, Kurreck Jens, Gurlo Aleksander. Osteomimetic bioceramic scaffolds with high-fidelity human-bone features produced by rotational printing[J]. International Journal of Extreme Manufacturing, 2025, 7(3): 35005

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Received: Sep. 9, 2024

Accepted: Sep. 29, 2025

Published Online: Sep. 29, 2025

The Author Email:

DOI:10.1088/2631-7990/ada7aa

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