[1] [1] Peres M A, Macpherson L M, Weyant R J, et al. Oral diseases: a global public health challenge[J]. The Lancet, 2019, 394(10194): 249-260.

[3] [3] Tonetti M S, Greenwell H, Kornman K S. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition[J]. Journal of Periodontology, 2018, 89: S159-S172.

[4] [4] Zhang C Z, Cheng X Q, Li J Y, et al. Saliva in the diagnosis of diseases[J]. International Journal of Oral Science, 2016, 8(3): 133-137.

[7] [7] Bibi T, Khurshid Z, Rehman A, et al. Gingival Crevicular Fluid (GCF): A Diagnostic Tool for the Detection of Periodontal Health and Diseases[J]. Molecules, 2021, 26: 1208.

[8] [8] Gonchukov S, Sukhinina1A, Bakhmutov D, et al. Periodontitis diagnostics using resonance Raman spectroscopy on saliva[J]. Laser Physics Letters, 2013, 10: 075610.

[9] [9] Fatima T, Khurshid Z, Rehman A, et al. Gingival Crevicular Fluid (GCF): A Diagnostic Tool for the Detection of Periodontal Health and Diseases. Molecules. 2021, 26(5): 1208.

[10] [10] Umeizudike K A, Lhteenmki H, Risnen I T, et al. Ability of matrix metalloproteinase-8 biosensor, IFMA, and ELISA immunoassays to differentiate between periodontal health, gingivitis, and periodontitis[J]. Journal of Periodontal Research, 2022, 57(3): 558-567.

[11] [11] Wassall R R, Preshaw P M. Clinical and technical considerations in the analysis of gingival crevicular fluid[J]. Periodontol, 2000, 2016, 70(1): 65-79.

[14] [14] Fleischmann M, Hendra P J, McQuillan A J. Raman Spectra of Pyridine Adsorbed at a Silver Electrode[J]. Chemical Physics Letters, 1974, 26(2): 163-166.

[15] [15] Constantinou M, Hadjigeorgiou K, Abalde-Cela S, et al. Label-Free Sensing with Metal Nanostructure-Based Surface-Enhanced Raman Spectroscopy for Cancer Diagnosis[J]. ACS Applied Nano Materials, 2022, 5: 12276-12299.

[16] [16] Kneipp K, Wang Y, Kneipp H, et al. Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)[J]. Physical Review Letters, 1997, 78: 1667-1670.

[17] [17] Hernndez-Cedillo A, Garca-Valdivieso M Gu, Hernndez-Arteaga A C, et al. Determination of sialic acid levels by using surface-enhanced Raman spectroscopy in periodontitis and gingivitis[J]. Oral Diseases, 2019, 25: 1627-1633.

[18] [18] Fornasaro S, Berton F, Stacchi C, et al. Label-free analysis of gingival crevicular fluid (GCF) by surface enhanced Raman scattering (SERS)[J]. Analyst, 2021, 146: 1464-1471.

[19] [19] Yang H, Zhang M L, Chen Y, et al. Surface-Enhanced Raman Scattering-Based Technique for Detecting Periodontal Disease[J]. Journal of Applied Spectroscopy, 2022, 88(6): 1189-1194.

[20] [20] Chen S, Wu H, Chen C, et al. The prognostic prediction of periodontal non-surgery therapy in periodontitis patients based on surface-enhanced Raman measurements of pre-treatment saliva[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 288: 122150.

[21] [21] Xia Y, Gilroy K D, Peng H C, et al. Seed-Mediated Growth of Colloidal Metal Nanocrystals[J]. Angewandte Chemie International Edition, 2017, 56(1): 60-95.

[22] [22] Han S Q G W, Zhang C, Lin S, et al. Sensitive and reliable identification of fentanyl citrate in urine and serum using chloride ion-treated paper-based SERS substrate[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 251(15): 119463.

[23] [23] Lussier F, Thibault V, Charron B, et al. Deep learning and artificial intelligence methods for Raman and surface-enhanced Raman scattering[J]. Trends in Analytical Chemistry, 2020, 124: 115796.

[25] [25] Han S, Jin Z, Deji D, et al. Study on the Classification and Identification of Various Carbonate and Sulfate Mineral medicines Based on Raman Spectroscopy Combined with PCA-SVM Algorithm[J]. Analytical Sciences, 2023, 39: 241-248.

[26] [26] Sha X, Fang G Q, Cao G X, et al. Qualitative and quantitative detection and identification of two benzodiazepines based on SERS and convolutional neural network technology[J]. Analyst, 2022, 147: 5785-5795.

[28] [28] Guan H, Fang G, Li X, et al. Au@Ag Nanocube-Coated Polystyrene Microspheres as Hierarchical SERS Substrates for Trace Detection of As5+[J]. ACS Applied Nano Materials, 2023, 6: 23037-23046.

[29] [29] Buchan E, Kelleher L, Clancy M, et al. Spectroscopic molecular-fingerprint profiling of saliva[J]. Analytica Chimica Acta, 2021, 1185: 339074.