Experimental Study of Indocyanine Green Pharmacokinetics Based on Adaptive Extended Kalman Filter

Zhang Yanqi; Zhang Limin; Zhao Zhichao; Ma Wenjuan; Gao Feng

doi:10.3788/CJL202047.0907002

Chinese Journal of Lasers, Volume. 47, Issue 9, 907002(2020)

Experimental Study of Indocyanine Green Pharmacokinetics Based on Adaptive Extended Kalman Filter

Zhang Yanqi¹, Zhang Limin^1,2、*, Zhao Zhichao¹, Ma Wenjuan³, and Gao Feng^1,2

Author Affiliations

¹School of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China

²Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China

³Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China

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Figures & Tables(7)

Fig. 1. Two-compartmental model of ICG pharmacokinetics

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Fig. 2. Schematic of dynamic DFT system

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Fig. 3. Results of experiment with healthy mouse. (a) XCT image; (b) fluorescence yield image (about 2 min)

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Fig. 4. Time-series ICG permeability images of the healthy mouse liver. (a) K_pe; (b) K_ep

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Fig. 5. Results of experiment with tumor-burdened mouse. (a) Cryosection image; (b) fluorescence yield image (about 2 min)

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Fig. 6. Time-series ICG permeability images of the tumor. (a) K_pe; (b) K_ep

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Table 1. Comparison of ICG permeability parameters in the healthy mouse liver and tumor (mean±SD)
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Table 1. Comparison of ICG permeability parameters in the healthy mouse liver and tumor (mean±SD)
Tissue (samplenumber n=3) Permeability parameters
K_pe /s^-1 K_ep /s^-1
Liver 0.0050±0.0004 0.0014±0.0001
Tumor 0.0024±0.0001 0.0008±0.0001

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Zhang Yanqi, Zhang Limin, Zhao Zhichao, Ma Wenjuan, Gao Feng. Experimental Study of Indocyanine Green Pharmacokinetics Based on Adaptive Extended Kalman Filter[J]. Chinese Journal of Lasers, 2020, 47(9): 907002

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