A hole defect in the ZTC4 titanium alloy plate is repaired by the coaxial powder-feeding laser-cladding technology. The effects of multiple laser repairs on the microstructure, heat-affected zone size, and hardness distribution of repaired parts are investigated. The result shows that the heat-affected zone of the repaired specimen exhibits a microstructural transition from a basketweave structure to a colonies structure,and then transition to a needle-shaped martensite. The repaired area primarily comprises a coarse β-columnar crystal and widmanstatten structure, which is longer at the top of the repaired area. During multiple repairs, the size of the heat-affected zone considerably increases. However, the hardness of the heat-affected zone only increases slightly.