Technique and Properties of Femtosecond Laser Welding <i>In Vitro</i> Skin Tissue

Ziyan Song; Jun Huang; Yingzhe Li; Qitong Li; Shengnan Xia; Kehong Wang; Yunfeng Rui

doi:10.3788/CJL202249.2007107

Chinese Journal of Lasers, Volume. 49, Issue 20, 2007107(2022)

Technique and Properties of Femtosecond Laser Welding In Vitro Skin Tissue

Ziyan Song^1、*, Jun Huang^1、**, Yingzhe Li¹, Qitong Li¹, Shengnan Xia¹, Kehong Wang¹, and Yunfeng Rui²

¹School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, Jiangsu, China

²Orthopedics, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu, China

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Figures & Tables(11)

Fig. 1. In vitro skin tissue sample

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Fig. 2. Morphologies of in vitro skin tissues under different laser powers. (a) 14 W; (b) 16 W; (c) 18 W; (d) 20 W

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Fig. 3. Morphologies of in vitro skin tissues at different defocus amounts. (a) 0; (b) －0.5 mm; (c) －1.0 mm；(d) －1.5 mm

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Fig. 4. Morphologies of in vitro skin tissues at different scanning speeds. (a) 30 mm/s; (b) 50 mm/s; (c) 70 mm/s；(d) 90 mm/s

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Fig. 5. Morphologies of in vitro skin tissues under different numbers of scannings. (a) 50; (b) 100; (c) 150

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Fig. 6. Tensile strength of in vitro skin tissue versus each parameter. (a) Power; (b) defocus amount; (c) scanning speed；(d) number of scannings

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Fig. 7. Thermal damage parameter of in vitro skin tissue versus each parameter. (a) Power; (b) defocus amount; (c) scanning speed; (d) number of scannings

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Fig. 8. Appearance of in vitro skin tissue after laser scanning. (a) Front; (b) back

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Table 1. Experimental parameter design

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Table 1. Experimental parameter design

Serial number	Power /W	Defocus amount /mm	Scanning speed /(mm·s^－1)	Number of scannings
1	14	－0.5	50	75
2	16	－0.5	50	75
3	18	－0.5	50	75
4	20	－0.5	50	75
5	16	0	50	75
6	16	－1.0	50	75
7	16	－1.5	50	75
8	18	－0.5	30	75
9	18	－0.5	70	75
10	18	－0.5	90	75
11	16	－0.5	50	50
12	16	－0.5	50	100
13	16	－0.5	50	150

Table 2. Tensile strength and thermal damage parameters of in vitro skin tissues after welding under different parameters

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Table 2. Tensile strength and thermal damage parameters of in vitro skin tissues after welding under different parameters

Serial number	Power /W	Defocus amount /mm	Scanning speed /(mm·s^－1)	Number of scannings	Tensile strength /(N·cm^－2)	Thermal damage parameter
1	14	－0.5	50	75	1.975	9.898×10^－8
2	16	－0.5	50	75	4.425	2.484×10^－6
3	18	－0.5	50	75	14.625	0.016
4	20	－0.5	50	75	15.550	199.983
5	16	0	50	75	3.600	6.497×10^－6
6	16	－1.0	50	75	3.200	3.243×10^－6
7	16	－1.5	50	75	2.850	2.471×10^－6
8	18	－0.5	30	75	22.500	0.449
9	18	－0.5	70	75	12.775	4.895×10^－3
10	18	－0.5	90	75	2.625	0.025
11	16	－0.5	50	50	1.875	6.389×10^－6
12	16	－0.5	50	100	9.950	8.153×10^－4
13	16	－0.5	50	150	9.850	4.187×10^－3

Table 3. Optimization parameters for femtosecond laser connection of in vitro skin tissue
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Table 3. Optimization parameters for femtosecond laser connection of in vitro skin tissue
Power /W Defocus amount /mm Scanning speed /(mm·s^－1) Number of scannings
16 －0.5 30 100

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Ziyan Song, Jun Huang, Yingzhe Li, Qitong Li, Shengnan Xia, Kehong Wang, Yunfeng Rui. Technique and Properties of Femtosecond Laser Welding In Vitro Skin Tissue[J]. Chinese Journal of Lasers, 2022, 49(20): 2007107

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Paper Information

Category: Optical Diagnostics and Therapy

Received: Jun. 22, 2022

Accepted: Jul. 22, 2022

Published Online: Oct. 17, 2022

The Author Email: Song Ziyan (songziyan0406@163.com), Huang Jun (huangjun@njust.edu.cn)

DOI:10.3788/CJL202249.2007107

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Experimental parameter design

Table 1. Experimental parameter design

Table 2. Tensile strength and thermal damage parameters of in vitro skin tissues after welding under different parameters

Table 2. Tensile strength and thermal damage parameters of in vitro skin tissues after welding under different parameters

Table 3. Optimization parameters for femtosecond laser connection of in vitro skin tissue

Table 3. Optimization parameters for femtosecond laser connection of in vitro skin tissue