Laser & Optoelectronics Progress, Volume. 57, Issue 23, 230401(2020)

Microwave Non-Invasive Blood Glucose Detection Based on Debye Model

Min Hu1,2, Xia Xiao1,2、*, Hang Song1,2, and Yu Liu1,2
Author Affiliations
  • 1School of Microelectronics, Tianjin University, Tianjin 300072, China
  • 2Tianjin Key Laboratory of Imaging and Sensing Microelectronic Technology, Tianjin 300072, China
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    Figures & Tables(18)
    Diagram of open-end coaxial probe measurement principle
    Experimental device. (a) Measurement equipment; (b) open-end coaxial probe; (c) network analyzer
    Dielectric properties of glucose aqueous solution with different concentrations. (a) Dielectric constant; (b) conductivity
    Fitting relation between Debye parameters and glucose aqueous solution concentration. (a) ε∞; (b) Δε; (c) τ
    Single-order Debye model fitting of glucose aqueous solution with concentration of 200 mg·dl-1. (a) Dielectric constant; (b) conductivity
    Dielectric properties of five aqueous glucose solutions reconstructed by single-order Debye model. (a) Dielectric constant; (b) conductivity
    Five-layer earlobe electromagnetic model and transceiver antenna
    Single-order Debye model of skin and fat. (a) Dielectric constant; (b) conductivity
    Microwave signal transmitted by transmitting antenna. (a) Time domain diagram; (b) frequency domain diagram
    Changes of S21 at different glucose concentrations. (a) S21; (b) S21 difference; (c) absolute value of S21 difference
    Relationship between absolute value of S21 difference and glucose concentration at different frequency points. (a) 1.35 GHz; (b) 1.63 GHz; (c) 3.25 GHz; (d) 4 GHz
    Experimental environment. (a) Experimental device; (b) earlobe model and antenna
    Experimental measurement results. (a) S21; (b) S21 difference; (c) absolute value of S21 difference
    Relationship between absolute value of S21 difference and glucose concentration at different frequency points
    • Table 1. Fitting parameters of single-order Debye model of glucose aqueous solution with different concentrations

      View table

      Table 1. Fitting parameters of single-order Debye model of glucose aqueous solution with different concentrations

      Concentration /(mg·dl-1)εΔετ /ps
      09.99169.1559.26
      10010.02869.0349.24
      20010.14268.7829.22
      30010.48368.3759.28
      40010.95667.9019.36
      50011.26767.5509.42
      60011.51467.2639.47
      70012.26066.4799.57
      80012.34266.3489.57
      90012.67065.9539.62
      100013.13365.4089.69
    • Table 2. Fitted RMSE of Debye model at different glucose concentrations

      View table

      Table 2. Fitted RMSE of Debye model at different glucose concentrations

      Concentration /(mg·dl-1)DielectricconstantConductivity /(S·m-1)
      00.2710.097
      1000.2590.097
      2000.2550.096
      3000.3060.107
      4000.3050.109
      5000.3190.108
      6000.2920.112
      7000.3000.109
      8000.3090.105
      9000.2990.104
      10000.3070.105
    • Table 3. RMSE of quadratic polynomial fitting of Debye parameters

      View table

      Table 3. RMSE of quadratic polynomial fitting of Debye parameters

      ParameterRMSE
      ε0.131
      Δε0.033
      τ /ps0.031
    • Table 4. Single-order Debye parameters of skin and fat

      View table

      Table 4. Single-order Debye parameters of skin and fat

      Biological tissueεεsτ /ps
      Skin22.768042.488925.3633
      Fat2.28464.60889.2819
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    Min Hu, Xia Xiao, Hang Song, Yu Liu. Microwave Non-Invasive Blood Glucose Detection Based on Debye Model[J]. Laser & Optoelectronics Progress, 2020, 57(23): 230401

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    Paper Information

    Category: Detectors

    Received: Feb. 20, 2020

    Accepted: Apr. 10, 2020

    Published Online: Dec. 2, 2020

    The Author Email: Xia Xiao (xiaxiao@tju.edu.cn)

    DOI:10.3788/LOP57.230401

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