Acta Laser Biology Sinica, Volume. 33, Issue 6, 550(2024)
Empagliflozin Alleviates Acute Pancreatitis by Inhibiting Apoptosis in Rats
[1] [1] LEE P J, PAPACHRISTOU G I. New insights into acute pancreatitis[J]. Nature Reviews. Gastroenterology & Hepatology, 2019, 16(8): 479-496.
[2] [2] TAN J H, CAO R C, ZHOU L, et al. EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis[J]. Cell Death & Disease, 2020, 11(11): 966.
[3] [3] LIU D, WEN L, WANG Z, et al. The mechanism of lung and intestinal injury in acute pancreatitis: a review[J]. Frontiers in Medicine, 2022, 9: 904078.
[4] [4] ASADI M, TAGHIZADEH S, KAVIANI E, et al. Caspase-3: structure, function, and biotechnological aspects[J]. Biotechnology and Applied Biochemistry, 2022, 69(4): 1633-1645.
[5] [5] ABDEL-LATIF R G, RIFAAI R A, AMIN E F. Empagliflozin alleviates neuronal apoptosis induced by cerebral ischemia/reperfusion injury through HIF-1/VEGF signaling pathway[J]. Archives of Pharmacal Research, 2020, 43(5): 514-525.
[6] [6] WANG C C, LI Y, QIAN X Q, et al. Empagliflozin alleviates myocardial I/R injury and cardiomyocyte apoptosis via inhibiting ER stress-induced autophagy and the PERK/ATF4/Beclin1 pathway[J]. Journal of Drug Targeting, 2022, 30(8): 858-872.
[7] [7] WANG Q, JU F, LI J, et al. Empagliflozin protects against renal ischemia/reperfusion injury in mice[J]. Scientific Reports, 2022, 12(1): 19323.
[8] [8] NASIRI-ANSARI N, NIKOLOPOULOU C, PAPOUTSI K, et al. Empagliflozin attenuates non-alcoholic fatty liver disease in high fat diet fed apoe (-/-) mice by activating autophagy and reducing er stress and apoptosis[J]. International Journal of Molecular Sciences, 2021, 22(2): 818.
[9] [9] SCHMIDT J, RATTNER D W, LEWANDROWSKI K, et al. A better model of acute pancreatitis for evaluating therapy[J]. Annals of Surgery, 1992, 215(1): 44-56.
[10] [10] ROSSETTI L, SHULMAN G I, ZAWALICH W, et al. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats[J]. The Journal of Clinical Investigation, 1987, 80(4): 1037-1044.
[11] [11] AL JOBORI H, DANIELE G, ADAMS J, et al. Empagliflozin treatment is associated with improved -cell function in type 2 diabetes mellitus[J]. The Journal of Clinical Endocrinology and Metabolism, 2018, 103(4): 1402-1407.
[12] [12] FERRANNINI E, MUSCELLI E, FRASCERRA S, et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients[J]. The Journal of Clinical Investigation, 2014, 124(2): 499-508.
[13] [13] PAN X, FANG X, WANG F, et al. Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms[J]. British Journal of Pharmacology, 2019, 176(23): 4446-4461.
[14] [14] SIRIVIRIYAKUL P, SRIKO J, SOMANAWAT K, et al. Genistein attenuated oxidative stress, inflammation, and apoptosis in L-arginine induced acute pancreatitis in mice[J]. BMC Complementary Medicine and Therapies, 2022, 22(1): 208.
[15] [15] MALLEO G, MAZZON E, SIRIWARDENA A K, et al. Role of tumor necrosis factor-alpha in acute pancreatitis: from biological basis to clinical evidence[J]. Shock (Augusta, Ga.), 2007, 28(2): 130-140.
[16] [16] GOTZMANN M, HENK P, STERVBO U, et al. Empagliflozin reduces interleukin-6 levels in patients with heart failure[J]. Journal of Clinical Medicine, 2023, 12(13): 4458.
[17] [17] KABEL A M, ESTFANOUS R S, ALROBAIAN M M. Targeting oxidative stress, proinflammatory cytokines, apoptosis and toll like receptor 4 by empagliflozin to ameliorate bleomycin-induced lung fibrosis[J]. Respiratory Physiology & Neurobiology, 2020, 273: 103316.
[18] [18] SENDLER M, MAYERLE J, LERCH M M. Necrosis, apoptosis, necroptosis, pyroptosis: it matters how acinar cells die during pancreatitis[J]. Cellular and Molecular Gastroenterology and Hepatology, 2016, 2(4): 407-408.
[19] [19] BHATIA M. Apoptosis of pancreatic acinar cells in acute pancreatitis: is it good or bad?[J]. Journal of Cellular and Molecular Medicine, 2004, 8(3): 402-409.
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LI Wenqing, LI Li. Empagliflozin Alleviates Acute Pancreatitis by Inhibiting Apoptosis in Rats[J]. Acta Laser Biology Sinica, 2024, 33(6): 550
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Received: Dec. 11, 2023
Accepted: Feb. 27, 2025
Published Online: Feb. 27, 2025
The Author Email: Li LI (lily9711214@126.com)