Photoacoustic characteristics of lipid-rich plaques under ultra-low temperature and formaldehyde treatment

Mingjun Xu; Peng Lei; Jianqin Feng; Fangfang Liu; Sihua Yang; Pengfei Zhang

doi:10.3788/COL201816.031702

Chinese Optics Letters, Volume. 16, Issue 3, 031702(2018)

Photoacoustic characteristics of lipid-rich plaques under ultra-low temperature and formaldehyde treatment On the Cover

Mingjun Xu¹, Peng Lei², Jianqin Feng³, Fangfang Liu¹, Sihua Yang^2、*, and Pengfei Zhang^1、**

¹Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China

²MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China

³Department of Cardiology, The Juye Hospital of Traditional Chinese Medicine, Heze 274900, China

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Fig. 1. Schematic of the system and photograph of the devices. (a) Schematic of the system: POL, plan objective lens; AMP, amplifier; DAQ, data acquisition system. (b) Schematic of the laser emission and PA signals reception. (c) Photograph of the integrated transducer.

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Fig. 2. Performance of the transducer and system. (a) The echo signal detected by the transducer. (b) Bandwidth of the transducer elements with a −6 dB bandwidth of 95%. (c) The axial resolution of the system. (d) The lateral resolution of the system.

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Fig. 3. Comparison of PA images experiencing pre- and post-frozen treatment with histological images. (a) The PA cross-section image of No. 2 vessel before frozen treatment. (b) The PA cross-section image of No. 2 vessel as shown in (a) after frozen treatment. (c) The matched histological cross-section image of No. 2 vessel in (a) and (b). LRC, lipid relative concentration.

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Fig. 4. Comparison of PA images experiencing pre- and post-formaldehyde treatment with histological images. (a) The PA cross-section image of No. 5 vessel before formaldehyde treatment. (b) The PA cross-section image of No. 5 vessel as shown in (a) after formaldehyde treatment. (c) The matched histological cross-section image of No. 5 vessel in (a) and (b).

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Fig. 5. Statistical analysis results. (a) Correlation between LR by histology and PAI post-frozen treatment, R2=0.942. (b) Correlation between LR by histology and PAI post-formaldehyde treatment, R2=0.551.

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Table 1. Difference and Correlation of Lipid Ratio Derived by PAI Pre- and Post-Treatments
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Table 1. Difference and Correlation of Lipid Ratio Derived by PAI Pre- and Post-Treatments
Difference Correlation
Before Treatment After Treatment P Value Pearson Coefficient P Value
Frozen ( $N = 13$ ) $0.334 \pm 0.130$ $0.329 \pm 0.122$ 0.299 0.990 0
Formaldehyde ( $N = 19$ ) $0.317 \pm 0.045$ $0.316 \pm 0.040$ 0.854 0.863 0

Table 2. Correlation of Lipid Ratio Derived by PAI and Histology Pre- and Post-Treatments
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Table 2. Correlation of Lipid Ratio Derived by PAI and Histology Pre- and Post-Treatments
PA Percentage Histological Percentage Correlation
Before processing $0.300 \pm 0.097$ $0.332 \pm 0.086$ 0.967
After processing $0.371 \pm 0.105$ $0.403 \pm 0.097$ 0.853

Table 3. Difference and Correlation of Lipid Ratio Derived by PAI and Histology Post-Frozen and Formaldehyde Treatment
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Table 3. Difference and Correlation of Lipid Ratio Derived by PAI and Histology Post-Frozen and Formaldehyde Treatment
PAI Histology $P$ Value Correlation
Frozen ( $N = 11$ ) $0.312 \pm 0.125$ $0.370 \pm 0.119$ 0.001 0.991
Formaldehyde ( $N = 25$ ) $0.397 \pm 0.085$ $0.433 \pm 0.071$ 0.011 0.658

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Mingjun Xu, Peng Lei, Jianqin Feng, Fangfang Liu, Sihua Yang, Pengfei Zhang, "Photoacoustic characteristics of lipid-rich plaques under ultra-low temperature and formaldehyde treatment," Chin. Opt. Lett. 16, 031702 (2018)

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Paper Information

Category: Medical optics and biotechnology

Received: Oct. 18, 2017

Accepted: Jan. 12, 2018

Published Online: Jul. 13, 2018

The Author Email: Sihua Yang (yangsh@scnu.edu.cn), Pengfei Zhang (pengf-zhang@163.com)

DOI:10.3788/COL201816.031702

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Difference and Correlation of Lipid Ratio Derived by PAI Pre- and Post-Treatments

Table 1. Difference and Correlation of Lipid Ratio Derived by PAI Pre- and Post-Treatments

Table 2. Correlation of Lipid Ratio Derived by PAI and Histology Pre- and Post-Treatments

Table 2. Correlation of Lipid Ratio Derived by PAI and Histology Pre- and Post-Treatments

Table 3. Difference and Correlation of Lipid Ratio Derived by PAI and Histology Post-Frozen and Formaldehyde Treatment

Table 3. Difference and Correlation of Lipid Ratio Derived by PAI and Histology Post-Frozen and Formaldehyde Treatment