Laser & Optoelectronics Progress, Volume. 61, Issue 12, 1217002(2024)

Highly Sensitive Intraoperative Parathyroid Identification Device with Fiber-Optic Probe

Liang Chen1、*, Xi Chen2,3, Jiancong Li2, Yueqiao Wang2, and Rongqing Xu1
Author Affiliations
  • 1College of electronic and optical engineering, Nanjing University of Posts and Telecommunications, Nanjing 210003, Jiangsu, China
  • 2Beneeon (Jiangsu) Medical Technology Co., Ltd, Taizhou 225300, Jiangsu, China
  • 3School of electronic and optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, Jiangsu, China
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    Figures & Tables(15)
    Block diagram of device system design
    Traditional “L” optical structure of fluorescent detection
    Improved optical structure of fluorescent detection
    Comparison of photoelectric conversion efficiency of 1 mm2 CMOS/PD and SIPM. (a) PD/CMOS; (b) SIPM
    Design of high signal-to-noise ratio photoelectric conversion amplifier circuit
    Equivalent model of photoelectric sensor
    Indocyanine green and parathyroid fluorescence spectra. (a) Fluorescence spectra of parathyroid glands and other tissues; (b) ICG fluorescence spectra
    Fiber-optic probe and fluorescent reagent fixation tool
    Linear relationship between fluorescence intensity and ICG concentration
    Infrared fluorescence imager host and disposable optical fiber probe
    Fiber probe directly contacted the suspected parathyroid to obtain fluorescence intensity
    Comparison of fluorescence intensity between parathyroid gland and other tissues
    Pathological analysis confirmed parathyroid tissue
    Comparison of fluorescence intensity between parathyroid gland and other tissues[19]
    • Table 1. Recording table of ICG solution concentration and system measured fluorescence intensity

      View table

      Table 1. Recording table of ICG solution concentration and system measured fluorescence intensity

      Solution No.Molarity /(nmol/L)Mass concentration /(mg/dL)Fluorescence intensity
      13.002.33×10-445642
      21.501.16×10-423526
      31.007.75×10-515713
      40.604.65×10-59727
      50.302.33×10-54550
      60.201.55×10-53157
      70.107.75×10-61603
      80.053.88×10-6906
      900124
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    Liang Chen, Xi Chen, Jiancong Li, Yueqiao Wang, Rongqing Xu. Highly Sensitive Intraoperative Parathyroid Identification Device with Fiber-Optic Probe[J]. Laser & Optoelectronics Progress, 2024, 61(12): 1217002

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    Paper Information

    Category: Medical Optics and Biotechnology

    Received: Feb. 27, 2024

    Accepted: Apr. 10, 2024

    Published Online: Jun. 17, 2024

    The Author Email: Liang Chen (chenliang_appllo@163.com)

    DOI:10.3788/LOP240752

    CSTR:32186.14.LOP240752

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