Laser & Optoelectronics Progress, Volume. 61, Issue 12, 1217002(2024)

Highly Sensitive Intraoperative Parathyroid Identification Device with Fiber-Optic Probe

Liang Chen1、*, Xi Chen2,3, Jiancong Li2, Yueqiao Wang2, and Rongqing Xu1
Author Affiliations
  • 1College of electronic and optical engineering, Nanjing University of Posts and Telecommunications, Nanjing 210003, Jiangsu, China
  • 2Beneeon (Jiangsu) Medical Technology Co., Ltd, Taizhou 225300, Jiangsu, China
  • 3School of electronic and optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, Jiangsu, China
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    Based on the near-infrared autofluorescence characteristics of a parathyroid gland, a rapid intraoperative parathyroid identification device using highly sensitive laser-induced fluorescence (LIF) technology was developed. This paper describes the development of a fiber-optic probe-based non-invasive identification device for intraoperative parathyroid recognition. The device used a novel near-infrared sensing unit incorporated into a fluorescence collection module. By performing fluorescence experiments using indocyanine green (ICG) solution as a simulation of parathyroid autofluorescence, it was observed that the device exhibited a linear relationship between fluorescence intensity and ICG concentration, even at a low concentration of 0.05 nmol/L. The correlation coefficient between fluorescence intensity and ICG concentration was 0.999, indicating a strong correlation that closely matched the theoretical expectations. The device was tested in clinical experiments at the First People's Hospital in Guangzhou City. The experimental results demonstrated that the device successfully elicited autofluorescence from parathyroid glands. The fluorescence intensity of the parathyroid glands was approximately five times higher than those of other tissues, allowing for clear differentiation between the parathyroid glands and other tissues. Clinical experts concluded that the device can rapidly, non-invasively, and accurately identify parathyroid tissue, providing significant clinical value.

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    Liang Chen, Xi Chen, Jiancong Li, Yueqiao Wang, Rongqing Xu. Highly Sensitive Intraoperative Parathyroid Identification Device with Fiber-Optic Probe[J]. Laser & Optoelectronics Progress, 2024, 61(12): 1217002

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    Paper Information

    Category: Medical Optics and Biotechnology

    Received: Feb. 27, 2024

    Accepted: Apr. 10, 2024

    Published Online: Jun. 17, 2024

    The Author Email: Chen Liang (chenliang_appllo@163.com)

    DOI:10.3788/LOP240752

    CSTR:32186.14.LOP240752

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