Journal of Jiangsu University(Medicine Edition), Volume. 35, Issue 4, 277(2025)

Lipotoxic hepatocyte exosomes promote hepatic stellate cell activation by inhibiting ferroptosis

SHI Yujie1,2, WANG Yanjin1,2, and YAN Yongmin2、*
Author Affiliations
  • 1School of Medicine, Jiangsu University, Zhenjiang Jiangsu 212013
  • 2Department of Clinical Laboratory, Wujin Hospital, Jiangsu University, Changzhou Jiangsu 213017, China
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    References(13)

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    [4] [4] Ye Q, Zhou Y, Zhao C, et al. Salidroside inhibits CCl4-induced liver fibrosis in mice by reducing activation and migration of HSC induced by liver sinusoidal endothelial cell-derived exosomal SphK1[J]. Front Pharmacol, 2021, 12: 677810.

    [5] [5] Ma C, Wang C, Zhang Y, et al. Phillygenin inhibited M1 macrophage polarization and reduced hepatic stellate cell activation by inhibiting macrophage exosomal miR-125b-5p[J]. Biomed Pharmacother, 2023, 159: 114264.

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    [7] [7] Li X, Wang TX, Huang X, et al. Targeting ferroptosis alleviates methionine-choline deficient(MCD)-diet induced NASH by suppressing liver lipotoxicity[J]. Liver Int, 2020, 40(6): 1378-1394.

    [8] [8] Tang D, Chen X, Kang R, et al. Ferroptosis: molecular mechanisms and health implications[J]. Cell Res, 2021, 31(2): 107-125.

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    [10] [10] Averill-bates DA. The antioxidant glutathione[J]. Vitam Horm, 2023, 121: 109-141.

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    [13] [13] Kuo CY, Chiu V, Hsieh PC, et al. Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis[J]. J Pharmacol Sci, 2020, 144(3): 172-182.

    [15] [15] Luo X, Xu ZX, Wu JC, et al. Hepatocyte-derived exosomal miR-27a activateshepatic stellate cells through the inhibitionof PINK1-mediated mitophagy in MAFLD[J]. Mol Ther Nucleic Acids, 2021, 26: 1241-1254.

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    SHI Yujie, WANG Yanjin, YAN Yongmin. Lipotoxic hepatocyte exosomes promote hepatic stellate cell activation by inhibiting ferroptosis[J]. Journal of Jiangsu University(Medicine Edition), 2025, 35(4): 277

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    Paper Information

    Special Issue:

    Received: Jul. 27, 2024

    Accepted: Aug. 21, 2025

    Published Online: Aug. 21, 2025

    The Author Email: YAN Yongmin (yym@ujs.edu.cn)

    DOI:10.13312/j.issn.1671-7783.y240127

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