[1] [1] JOHNSTONE R M, BIANCHINI A, TENG K. Reticulocyte maturation and exosome release: transferrin receptor containing exosomes shows multiple plasma membrane functions［J］. Blood, 1989, 74(5): 1844-1851.

[2] [2] VALADI H, EKSTROM K, BOSSIOS A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cell［J］. Nature Cell Biology, 2007, 9(6): 654-659.

[3] [3] KALLURI R, LEBLEU V S. The biology, function, and biomedical applications of exosomes［J］. Science, 2020, 367(6478): 6977-6993.

[4] [4] ZHANG H G, GRIZZLE W E. A novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions［J］. The American Journal of Pathology, 2014, 184(1): 28-41.

[5] [5] SHKARINA K A, CHEREDNYK O V, VOLOSCHENKO I I, et al. Exosomes: messengers and mediators of tumor–stromal interactions［J］. Biopolymers and Cell, 2014, 30(6): 426-435.

[6] [6] BRINTON L T, SlOANE H S, KESTER M, et al. Formation and role of exosomes in cancer［J］. Cell and Molecular Life Sciences, 2015, 72(4): 659-671.

[7] [7] GUO W, GAO Y, LI N, et al. Exosomes: new players in cancer［J］. Oncology Reports, 2017, 38(2): 665-675.

[8] [8] NAWAZ M, CAMUSSI G, VALADI H, et al. The emerging role of extracellular vesicles as biomarkers for urogenital cancers［J］. Nature Reviews Urology, 2014, 11(12): 688-701.

[9] [9] KALLURI R. The biology and function of exosomes in cancer［J］. Journal of Clinical Investigation, 2017, 126(4): 1208-1215.

[11] [11] RAGHU K. The biology and function of exosomes in cancer［J］. Journal of Clinical Investigation, 2016, 126(4): 1208-1215.

[14] [14] WANG B, WANG X, HOU D, et al. Exosomes derived from acute myeloid leukemia cells promote chemoresistance by enhancing glycolysis-mediated vascular remodeling［J］. Journal of Cellular Physiology, 2018, 234(7): 10602-10614.

[15] [15] YAMASHITA T, KAMADA H, KANASAKI S, et al. Epidermal growth factor receptor localized to exosome membranes as a possible biomarker for lung cancer diagnosis［J］. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 2013, 68(12): 969-973.

[16] [16] SOO C Y, SONG Y, ZHENG Y, et al. Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells［J］. Immunology, 2012, 136(2): 192-197.

[17] [17] GERCEL-TAYLOR C, ATAY S, TULLIS R H, et al. Nanoparticle analysis of circulating cell-derived vesicles in ovarian cancer patients［J］. Analytical Biochemistry, 2012, 428(1): 44-53.

[18] [18] OROZCO A F, LEWIS D E. Flow cytometric analysis of circulating microparticles in plasma［J］. Cytometry Part A, 2010, 77A(6): 502-514.

[19] [19] TEH S K, ZHENG W, HO K Y, et al. Diagnostic potential of near-infrared Raman spectroscopy in the stomach: differentiating dysplasia from normal tissue［J］. British Journal of Cancer, 2008, 98(2): 457-465.

[20] [20] FENG S, ZHENG Z, XU Y, et al. A noninvasive cancer detection strategy based on gold nanoparticle surface-enhanced raman spectroscopy of urinary modified nucleosides isolated by affinity chromatography［J］. Biosensors & Bioelectronics, 2017, 91: 616-622.

[21] [21] FLEISCHMANN M, HENDRA P J, MCQUILLAN A J. Raman spectra of pyridine adsorbed at a silver electrode［J］. Chemical Physics Letters, 1974, 26(2): 163-166.

[22] [22] AUSTIN L A, OSSEIRAN S, EVANS C L. Raman technologies in cancer diagnostics［J］. Analyst, 2016, 141(2): 476-503.

[23] [23] ALBRECHT M G, CREIGHTON J A. Anomalously intense Raman spectra of pyridine at a silver electrode［J］. Journal of the American Chemical Society, 1977, 99(15): 5215-5217.

[24] [24] YUEN C, ZHENG W, HUANG Z. Surface-enhanced raman scattering: principles, nanostructures, fabrications, and biomedical applications［J］. Journal of Innovation in Optical Health Sciences, 2008, 1(2): 267-284.

[26] [26] TIRINATO L, GENTILE F, DI MASCOLO D, et al. SERS analysis on exosomes using super-hydrophobic surfaces［J］. Microelectronic Engineering, 2012, 97(3): 337-340.

[27] [27] LEE C, CARNEY R P, HAZARI S, et al. 3D plasmonic nanobowl platform for the study of exosomes in solution［J］. Nanoscale, 2015, 7(20): 9290-9297.

[28] [28] LEE C, CARNEY R, LAM K, et al. SERS analysis of selectively captured exosomes using an integrin-specific peptide ligand［J］. Journal of Raman Spectroscopy, 2017, 48: 1771-1776.

[29] [29] SIVASHANMUGAN K, HUANG W L, LIN C H, et al. Bimetallic nanoplasmonic gap-mode SERS substrate for lung normal and cancer-derived exosomes detection［J］. Journal of the Taiwan Institute of Chemical Engineers, 2017, 80: 149-155.

[30] [30] AVELLA-OLIVER M, PUCHADES R, WACHSMANN-HOGIU S, et al. Label-free SERS analysis of proteins and exosomes with large-scale substrates from recordable compact disks［J］. Sensors and Actuators B: Chemical, 2017, 252: 657-662.

[31] [31] KERR L T, GUBBINS L, GORZEL K W, et al. Raman spectroscopy and SERS analysis of ovarian tumour derived exosomes (TEXs): a preliminary study［C］. Proceedings of SPIE-The International Society for Optical Engineering, 2014, 9129: 91292-91299.

[32] [32] STREMERSCH S, MARRO M, PINCHASIK B E, et al. Identification of individual exosome-like vesicles by surface enhanced Raman spectroscopy［J］. Small, 2016, 12(24): 3292-3301.

[33] [33] PARK J, HWANG M, CHOI B H, et al. Exosome classification by pattern analysis of surface-enhanced Raman spectroscopy data for lung cancer diagnosis［J］. Analytical Chemistry, 2017, 89(12): 6695-6701.

[34] [34] CARMICHEAL J, HAYASHI C, HUANG X, et al. Label-free characterization of exosome via surface enhanced Raman spectroscopy for the early detection of pancreatic cancer［J］. Nanomedicine: Nanotechnology, Biology and Medicine, 2019, 16: 88-96.

[35] [35] SHIN H, SEUNGHYUN O, HONG S, et al. Early-stage lung cancer diagnosis by deep learning-based spectroscopic analysis of circulating exosomes［J］. ACS Nano, 2020, 14(5): 5435-5444.

[36] [36] ZONG S, WANG L, CHEN C, et al. Facile detection of tumor-derived exosomes using magnetic nanobeads and SERS nanoprobes［J］. Analytical Methods, 2016, 8(25): 5001-5008.

[37] [37] WANG Z, ZONG S, WANG Y, et al. Screening and multiple detection of cancerous exosomes using a SERS-based method［J］. Nanoscale, 2018, 10(19): 9053-9062.

[38] [38] TIAN Y, NING C, HE F, et al. Highly sensitive detection of exosomes by SERS using gold nanostar@Raman reporter@nanoshell structures modified with a bivalent cholesterol-labeled DNA anchor［J］. Analyst, 2018, 143(20): 4915-4922.

[39] [39] ZHANG X, LIU C, PEI Y, et al. Preparation of a novel Raman probe and its application in the detection of circulating tumor cells and exosomes［J］. ACS Applied Materials & Interfaces, 2019, 11(32): 28671-28680.

[40] [40] PANG Y, SHI J, YANG X, et al. Personalized detection of circling exosomal PD-L1 based on Fe3O4@TiO2 isolation and SERS immunoassay［J］. Biosensors and Bioelectronics, 2020, 148: 111800-111820.

[41] [41] MA D, HUANG C, ZHENG J, et al. Quantitative detection of exosomal microRNA extracted from human blood based on surface-enhanced Raman scattering［J］. Biosensors & Bioelectronics, 2018, 101: 167-173.

[42] [42] PANG Y, WANG C, LU L, et al. Dual-SERS biosensor for one-step detection of microRNAs in exosome and residual plasma of blood samples for diagnosing pancreatic cancer［J］. Biosensors & Bioelectronics, 2019, 130: 204-213.

[43] [43] LI T D, ZHANG R, CHEN H, et al. An ultrasensitive polydopamine bi-functionalized SERS immunoassay for exosome-based diagnosis and classification of pancreatic cancer［J］. Chemical Science, 2018, 9(24): 5372-5382.

[44] [44] ALLIE K E, RYAN O, VOJTECH V, et al. Molecular detection and analysis of exosomes using surface-enhanced Raman scattering gold nanorods and a miniaturized device［J］. Theranostics, 2018, 8(10): 2722-2738.

[45] [45] LEE J U, KIM W H, LEE H S, et al. Quantitative and specific detection of exosomal miRNA for accurate diagnosis of breast cancer using a surface-enhanced Raman scattering sensor based on plasmonic head-flocked gold nanopillars［J］. Small, 2019, 15(17): 1804968-1804978.