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Forensic Sciences Research, Volume. 9, Issue 2, owae027(2024)

Case reports on uniparental disomy of chromosomes 6 and 3 in paternity testing

He Ren1,2、†, Zhiyong Liu3、†, Chong Chen4, Yan Shi4, Jiarong Zhang5, Ying Chen6, Li Jia4, Yacheng Liu4, and Jiangwei Yan5、*
Author Affiliations
  • 1Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, Academy of Forensic Science, Shanghai, China
  • 2Beijing Police College, Beijing, China
  • 3Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
  • 4Beijing Tongda Shoucheng Institute of Forensic Science, Beijing, China
  • 5School of Forensic Medicine, Shanxi Medical University, Jinzhong, China
  • 6Fangshan Branch of Beijing Public Security Bureau, Beijing, China
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    The positions of the genetic markers on chromosomes 6 and 3. Red: short tandem repeat marks; blue: single nucleotide polymorphism marks.

    Fig. 1. The positions of the genetic markers on chromosomes 6 and 3. Red: short tandem repeat marks; blue: single nucleotide polymorphism marks.

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    • Table 1. Genotyping results of the genetic markers on chromosomes 6 and 3 based on capillary electrophoresis (CE) and massively parallel sequencing (MPS) platforms.

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      Table 1. Genotyping results of the genetic markers on chromosomes 6 and 3 based on capillary electrophoresis (CE) and massively parallel sequencing (MPS) platforms.

      MarkerCase 1: chromosome 6MarkerCase 2: chromosome 3
      LocationMotherChild (male)Alleged fatherLocationAlleged motherChild (male)
      D6S10436q1519, 201212, 18D3S13583p21.311617
      D6S4746q21151714, 17D3S17443q241918
      D6S10176p21.110109, 10D3S30453q13.12911
      SE336q14221916, 19D3S45293p12.115, 1617
      rs38231596q23.3AAGGAGrs124981383q13.33GGGG
      rs1926556q15GAGGGArs19195503q13.33AAAA
      rs132184406p24.2GAGGGArs13576173p26.3ATAA
      rs2149556q25.2CTCCCCrs64447243q29TCCC
      rs7278116q27TTTTTTrs13553663q28TTCC
      rs13360716q16.1TTCCTCrs23993323q13.13TTGG
      rs122035926p25.3CCCCCCrs43642053p22.3TGTT
      rs49592706p25.3CCCCCArs141343q12.3CCCC
      rs13378236p12.3GGAAAArs22931953q25.31GGAA
      rs19976606p22.1GGGGAGrs74290103q27.1AAGG
      rs22742126p24.3TTCCCTrs98218803q28TTTT
      rs5742026p12.1AGGGAGrs117142393p26.3GTTT
      rs69093066p21.1CCCCCCrs4727283q26.31GAAA
      rs77415366q14.1AGGGAGrs40760863p22.3TTCC
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    He Ren, Zhiyong Liu, Chong Chen, Yan Shi, Jiarong Zhang, Ying Chen, Li Jia, Yacheng Liu, Jiangwei Yan. Case reports on uniparental disomy of chromosomes 6 and 3 in paternity testing[J]. Forensic Sciences Research, 2024, 9(2): owae027

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    Paper Information

    Category: Research Articles

    Received: Nov. 18, 2023

    Accepted: Apr. 9, 2024

    Published Online: Sep. 22, 2025

    The Author Email: Jiangwei Yan (yanjw@sxmu.edu.cn)

    DOI:10.1093/fsr/owae027

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