Chinese Journal of Lasers, Volume. 47, Issue 2, 207001(2020)

Mueller Matrix Polarimetry: A Label-Free, Quantitative Optical Method for Clinical Diagnosis

Shen Yuanxing1,2, Yao Yue3, He Honghui1, Liu Shaoxiong4, and Ma Hui1,3,5、*
Author Affiliations
  • 1Guangdong Research Center of Polarization Imaging and Measurement Engineering Technology, Shenzhen KeyLaboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing,Shenzhen International Graduate School, Tsinghua University, Shenzhen, Guangdong 518055, China
  • 2Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China
  • 3Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, Guangdong 518071, China
  • 4Shenzhen Sixth People''s Hospital (Nanshan Hospital), Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong 518052, China
  • 5Department of Physics, Tsinghua University, Beijing 100084, China
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    Figures & Tables(5)
    Schematics. (a) Schematic of the backscattering Mueller matrix imaging equipment; (b) photograph and schematic of transmission Mueller matrix microscope
    Backscattering Mueller matrices of four biological samples[32]. All the Mueller matrix elements are normalized by the m11. The color codes are from -1 to 1 for m11, m22, m33, and m44, and from -0.1 to 0.1 for other elements. (a) Chicken heart tissue, the black arrow line in m11 indicates the approximate orientation of muscle fibers; (b) bov
    Average values of MMT parameter A for three nude mouse skin samples without and with the application of sunscreen[36]. The areas under the frequency distribution curves are normalized to 1, and the horizontal axis is divided into 400 parts. (a) Without the application of sunscreen; (b) with the application of sunscreen; (c) not exposed to UV radiation
    Images of 8-μm-thick dewaxing slice of liver tissue with fibrosis in different stages and quantitative representation of some polarization parameters[54]. (a) F1 stage; (b) F2 stage; (c) F3 stage; (d) F4 stage; (e) average experimental values of parameters δ and t in different stages; (f) statistical distribution histograms of experimental results for parameter θ in different stages
    Mueller matrix derived parameters images δ, θ, t3 and x356. (a)(b) Crohn's dis
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    Shen Yuanxing, Yao Yue, He Honghui, Liu Shaoxiong, Ma Hui. Mueller Matrix Polarimetry: A Label-Free, Quantitative Optical Method for Clinical Diagnosis[J]. Chinese Journal of Lasers, 2020, 47(2): 207001

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Nov. 11, 2019

    Accepted: --

    Published Online: Feb. 21, 2020

    The Author Email: Hui Ma (mahui@tsinghua.edu.cn)

    DOI:10.3788/CJL202047.0207001

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