High Power Laser Science and Engineering, Volume. 11, Issue 2, 02000e20(2023)

Feasibility study of laser-driven neutron sources for pharmaceutical applications Editors' Pick

Takato Mori1, Akifumi Yogo1、*, Yasunobu Arikawa1, Takehito Hayakawa1,2, Seyed R. Mirfayzi3, Zechen Lan1, Tianyun Wei1, Yuki Abe1,4, Mitsuo Nakai1, Kunioki Mima1, Hiroaki Nishimura5, Shinsuke Fujioka1, and Ryosuke Kodama1
Author Affiliations
  • 1Institute of Laser Engineering, Osaka University, Suita, Japan
  • 2National Institutes for Quantum Science and Technology, Tokai, Japan
  • 3Tokamak Energy Ltd., Abingdon, UK
  • 4Graduate School of Engineering, Osaka University, Suita, Japan
  • 5Fukui University of Technology, Fukui, Japan
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    Figures & Tables(8)
    Partial nuclear chart around Zn and nuclear reactions with neutrons on a natural Zn target. Cu, Cu and Cu are produced by (n, p) reactions with high-energy neutrons on Zn, Zn and Zn, respectively. Cu, Cu and Cu are produced by (n, 2n) reactions on Zn, Zn and Zn, respectively. Cu and Cu are generated by (n, pn) reactions from Zn and Zn, respectively. High-energy neutrons could produce Ni by the Zn(n, )Ni reaction. Neutron capture also occurs.
    Experimental setup for the laser shot to generate neutrons. The laser is focused on the CD foil target. The Be neutron converter is placed 4 mm downstream of the CD foil. Behind the Be target, the Zn target was set in the hole at the center of the front surface.
    Fast neutron spectrum obtained from the TOF measurement. The neutron energies reached 17 MeV.
    -ray spectra measured for 120 h, 8.1 h, 5.1 h and 8 min. (a)–(c) The -ray spectra integrated for 120 h. The background signal measured for 99 h was normalized to the target measurement of 120 h. (d) The -ray spectrum measured for 8.1 h, where peaks corresponding to Znm are observed. (e) The -ray spectrum for 5.1 h, where peaks for Ni are observed. (f) The -ray spectrum for 8 min, which shows the Cum peak at 526 keV.
    Cross sections used in the simulation calculation, which are taken from the JENDL-4.0 nuclear data library.
    Geometry of the calculation of the yield of Cu using a laser for an optimized target system. (a) Cross-sectional view of the Be and Zn target. (b) 3D image of the target.
    • Table 1. Produced nuclides and their half-lives, -ray energies, emission probabilities of the -rays, nuclear reactions, numbers and activities.

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      Table 1. Produced nuclides and their half-lives, -ray energies, emission probabilities of the -rays, nuclear reactions, numbers and activities.

      Activity (Bq)
      Nuclide ${T}_{1/2}$ ${E}_{\gamma }$ (keV) ${I}_{\gamma }$ ( $\%$ )Nuclear reactionQuantities of the nuclides $t=0$  h $t=12$  h
      ${}^{63}$ Zn38.47 min669.628 ${}^{64}$ Zn(n, 2n)(9.3 $\pm$ 0.8) $\times$ 10 ${}^5$ (28 $\pm$ 2) $\times$ 10(6.5 $\pm$ 0.6) $\times {10}^{-4}$
      962.066.5
      ${}^{65}$ Zn224.26 d1115.5550.6 ${}^{64}$ Zn(n, $\gamma$ ) and ${}^{66}$ Zn(n, 2n)(1.45 $\pm$ 0.15) $\times$ 10 ${}^7$ 0.52 $\pm$ 0.05(5.2 $\pm$ 0.5) $\times {10}^{-1}$
      ${}^{69}$ Znm13.76 h438.694.77 ${}^{68}$ Zn(n, $\gamma$ ) and ${}^{70}$ Zn(n, 2n)(6.6 $\pm$ 0.4) $\times$ 10 ${}^5$ 9.2 $\pm$ 0.65.0 $\pm$ 0.3
      ${}^{71}$ Zn2.45 min910.277.8 ${}^{70}$ Zn(n, $\gamma$ ) $<$ 1.5 $\times$ 10 ${}^5$ $<$ 710 $<$ 2.4 $\times {10}^{-86}$
      ${}^{71}$ Znm3.96 h386.2893 ${}^{70}$ Zn(n, $\gamma$ )(1.9 $\pm$ 0.5) $\times$ 10 ${}^4$ 0.8 $\pm$ 0.2(1.1 $\pm$ 0.3) $\times {10}^{-1}$
      487.3862
      596.1427.9
      620.1857
      ${}^{64}$ Cu12.7 h1345.840.473 ${}^{64}$ Zn(n, p)(5.9 $\pm$ 0.5) $\times$ 10 ${}^7$ (89 $\pm$ 8) $\times$ 10(4.7 $\pm$ 0.4) $\times {10}^2$
      ${}^{66}$ Cu5.12 min1039.239 ${}^{66}$ Zn(n, p) and ${}^{67}$ Zn(n, np)(2.03 $\pm$ 0.25) $\times$ 10 ${}^6$ (458 $\pm$ 56) $\times$ 10(2.1 $\pm$ 0.3) $\times {10}^{-39}$
      ${}^{67}$ Cu61.83 h93.316.1 ${}^{67}$ Zn(n, p), ${}^{68}$ Zn(n, np)(3.3 $\pm$ 0.5) $\times$ 10 ${}^5$ 1.0 $\pm$ 0.2(9.0 $\pm$ 1.4) $\times {10}^{-1}$
      184.648.7
      ${}^{68}$ Cum3.75 min525.973 ${}^{68}$ Zn(n, p)(3.2 $\pm$ 1.4) $\times$ 10 ${}^4$ 99 $\pm$ 43(1.6 $\pm$ 0.7) $\times {10}^{-56}$
      ${}^{65}$ Ni2.52 h366.274.81 ${}^{68}$ Zn(n, $\alpha$ )(1.8 $\pm$ 0.2) $\times$ 10 ${}^5$ 14 $\pm$ 2(5.1 $\pm$ 0.6) $\times {10}^{-1}$
      1115.5515.43
      1481.8424
    • Table 2. Experimental activities, calculated activities and their ratio of the obtained activities in the present experiment. The calculated activities were obtained using the PHITS simulation code with the measured neutron energy spectrum.

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      Table 2. Experimental activities, calculated activities and their ratio of the obtained activities in the present experiment. The calculated activities were obtained using the PHITS simulation code with the measured neutron energy spectrum.

      Activity (Bq)
      NuclideExperimentSimulationExp/Sim ratio
      ${}^{63}$ Zn(282 $\pm$ 2) $\times$ 101.40200
      ${}^{65}$ Zn0.52 $\pm$ 0.050.192.8
      ${}^{69}$ Znm9.2 $\pm$ 0.61.46.6
      ${}^{71}$ Zn $<$ 71030.6 $<$ 23
      ${}^{71}$ Znm0.8 $\pm$ 0.20.0420
      ${}^{64}$ Cu(89 $\pm$ 8) $\times$ 1037.223.9
      ${}^{66}$ Cu(458 $\pm$ 56) $\times$ 1059.277.4
      ${}^{67}$ Cu1.0 $\pm$ 0.20.0250
      ${}^{68}$ Cum99 $\pm$ 430.84118
      ${}^{65}$ Ni14 $\pm$ 20.3540
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    Takato Mori, Akifumi Yogo, Yasunobu Arikawa, Takehito Hayakawa, Seyed R. Mirfayzi, Zechen Lan, Tianyun Wei, Yuki Abe, Mitsuo Nakai, Kunioki Mima, Hiroaki Nishimura, Shinsuke Fujioka, Ryosuke Kodama. Feasibility study of laser-driven neutron sources for pharmaceutical applications[J]. High Power Laser Science and Engineering, 2023, 11(2): 02000e20

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    Paper Information

    Category: Research Articles

    Received: Nov. 11, 2022

    Accepted: Jan. 5, 2023

    Posted: Jan. 6, 2023

    Published Online: Apr. 23, 2023

    The Author Email: Akifumi Yogo (yogo-a@ile.osaka-u.ac.jp)

    DOI:10.1017/hpl.2023.4

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