Fast reconstruction in fluorescence molecular tomography using data compression of intra- and inter-projections

Jiulou Zhang; Junwei Shi; Simin Zuo; Fei Liu; Jing Bai; Jianwen Luo

doi:10.3788/COL201513.071002

Chinese Optics Letters, Volume. 13, Issue 7, 071002(2015)

Fast reconstruction in fluorescence molecular tomography using data compression of intra- and inter-projections

Jiulou Zhang¹, Junwei Shi¹, Simin Zuo¹, Fei Liu^1,2, Jing Bai¹, and Jianwen Luo^1,3、*

Author Affiliations

¹Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China

²Tsinghua-Peking Center for Life Sciences, Beijing 100084, China

³Center for Biomedical Imaging Research, Tsinghua University, Beijing 100084, China

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Fig. 1. The results of the phantom experiment. (a) Slice and (g) 3D view of the true double fluorescence targets. (b) Slice and (h) 3D view of the reconstructed images obtained from the conventional method without data compression. (c)–(f) Slice and (i)–(l) 3D view of the reconstructed images obtained from the FDC strategy with 2, 3, 4, and 6 adjacent projections in each group. (m) Computational time consumed using different methods. (n) RMSEs and (o) normalized intensity profiles along the dotted line in (a) using different methods. All images are normalized by the maximal values of the results.

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Fig. 2. Results of the in vivo mouse experiment. (a) Slice view of the in vivo mouse. (b) Slice and (f) 3D view of the reconstructed images obtained from the conventional method. (c)–(e) Slice and (g)–(i) 3D view of the reconstructed images obtained from the FDC with 2, 3, and 6 adjacent projections. (j) Computational time consumed using different methods. (k) RMSEs and (l) normalized intensity profiles along the dotted line in (a) using different methods. All images are normalized by the maximal values of the results.

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Table 1. The Scales of Weight Matrix before and after Compression
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Table 1. The Scales of Weight Matrix before and after Compression
Methods Phantom In vivo
Conventional $13764 \times 15028$ $13576 \times 15231$
FDC2 $3933 \times 15028$ $4150 \times 15231$
FDC3 $2888 \times 15028$ $2875 \times 15231$
FDC4 $2223 \times 15028$ Null
FDC6 $1558 \times 15028$ $1500 \times 15231$

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Jiulou Zhang, Junwei Shi, Simin Zuo, Fei Liu, Jing Bai, Jianwen Luo, "Fast reconstruction in fluorescence molecular tomography using data compression of intra- and inter-projections," Chin. Opt. Lett. 13, 071002 (2015)

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