Journal of Innovative Optical Health Sciences, Volume. 18, Issue 5, 2550012(2025)

Implantable bio-chip for visible and controllable microwave-induced transcranial acoustic generation

Weian Chao, Ruyi Wen, Yubin Gong, Qiang Liu*, and Lei Xi**
References(47)

[1] B. Rosin, M. Slovik, R. Mitelman, M. Rivlin-Etzion, S. N. Haber, Z. Israel, E. Vaadia, H. Bergman. Closed-loop deep brain stimulation is superior in ameliorating Parkinsonism. Neuron, 72, 370-384(2011).

[2] P. Boon, K. Vonck, V. De Herdt, A. Van Dycke, M. Goethals, L. Goossens, M. Van Zandijcke, T. De Smedt, I. Dewaele, R. Achten, W. Wadman, F. Dewaele, J. Caemaert, D. Van Roost. Deep brain stimulation in patients with refractory temporal lobe epilepsy. Epilepsia, 48, 1551-1560(2007).

[3] A. L. Crowell, P. Riva-Posse, P. E. Holtzheimer, S. J. Garlow, M. E. Kelley, R. E. Gross, L. Denison, S. Quinn, H. S. Mayberg. Long-term outcomes of subcallosal cingulate deep brain stimulation for treatment-resistant depression. Am. J. Psychiat., 176, 949-956(2019).

[4] Q. P. Hao, D. L. Wang, J. OuYang, H. Ding, G. Y. Wu, Z. Liu, R. E. Liu. Pallidal deep brain stimulation in primary Meige syndrome: Clinical outcomes and psychiatric features. J. Neurol. Neurosurg. Ps., 91, 1343-1348(2020).

[5] E. S. Boyden, F. Zhang, E. Bamberg, G. Nagel, K. Deisseroth. Millisecond-timescale, genetically targeted optical control of neural activity. Nat. Neurosci., 8, 1263-1268(2005).

[6] R. Chen, F. Gore, Q. A. Nguyen, C. Ramakrishnan, S. Patel, S. H. Kim, M. Raffiee, Y. S. Kim, B. Hsueh, E. Krook-Magnusson, I. Soltesz, K. Deisseroth. Deep brain optogenetics without intracranial surgery. Nat. Biotechnol., 39, 161-164(2021).

[7] A. R. Brunoni, M. A. Nitsche, N. Bolognini, M. Bikson, T. Wagner, L. Merabet, D. J. Edwards, A. Valero-Cabre, A. Rotenberg, A. Pascual-Leone, R. Ferrucci, A. Priori, P. S. Boggio, F. Fregni. Clinical research with transcranial direct current stimulation (tDCS): Challenges and future directions. Brain Stimul., 5, 175-195(2012).

[8] A. Majdi, L. van Boekholdt, S. Sadigh-Eteghad, M. Mc Laughlin. A systematic review and meta-analysis of transcranial direct-current stimulation effects on cognitive function in patients with Alzheimer’s disease. Mol. Psychiatr., 27, 2000-2009(2022).

[9] M. Hallett. Transcranial magnetic stimulation and the human brain. Nature, 406, 147-150(2000).

[10] M. Kobayashi, A. Pascual-Leone. Transcranial magnetic stimulation in neurology. Lancet Neurol., 2, 145-156(2003).

[11] I. G. Elbau, C. J. Lynch, J. Downar, F. Vila-Rodriguez, J. D. Power, N. Solomonov, Z. J. Daskalakis, D. M. Blumberger, C. Liston. Functional connectivity mapping for rTMS target selection in depression. Am. J. Psychiat., 180, 230-240(2023).

[12] Y. Tufail, A. Matyushov, N. Baldwin, M. L. Tauchmann, J. Georges, A. Yoshihiro, S. I. H. Tillery, W. J. Tyler. Transcranial pulsed ultrasound stimulates intact brain circuits. Neuron, 66, 681-694(2010).

[13] Y. Tufail, A. Yoshihiro, S. Pati, M. M. Li, W. J. Tyler. Ultrasonic neuromodulation by brain stimulation with transcranial ultrasound. Nat. Protoc., 6, 1453-1470(2011).

[14] W. J. Tyler, S. W. Lani, G. M. Hwang. Ultrasonic modulation of neural circuit activity. Curr. Opin. Neurobiol., 50, 222-231(2018).

[15] Y. Meng, K. Hynynen, N. Lipsman. Applications of focused ultrasound in the brain: from thermoablation to drug delivery. Nat. Rev. Neurol., 17, 7-22(2021).

[16] S. S. Yoo, A. Bystritsky, J. H. Lee, Y. Z. Zhang, K. Fischer, B. K. Min, N. J. McDannold, A. Pascual-Leone, F. A. Jolesz. Focused ultrasound modulates region-specific brain activity. Neuroimage, 56, 1267-1275(2011).

[17] W. Lee, S. D. Lee, M. Y. Park, L. Foley, E. Purcell-Estabrook, H. Kim, K. Fischer, L. S. Maeng, S. S. Yoo. Image-guided focused ultrasound-mediated regional brain stimulation in sheep. Ultrasound Med. Biol., 42, 459-470(2016).

[18] G. F. Li, W. B. Qiu, Z. Q. Zhang, Q. J. Jiang, M. Su, R. L. Cai, Y. C. Li, F. Y. Cai, Z. T. Deng, D. Xu, H. L. Zhang, H. R. Zheng. Noninvasive ultrasonic neuromodulation in freely moving mice. IEEE Trans. Bio-Med. Eng., 66, 217-224(2019).

[19] R. F. Dallapiazza, K. F. Timbie, S. Holmberg, J. Gatesman, M. B. Lopes, R. J. Price, G. W. Miller, W. J. Elias. Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound. J Neurosurg, 128, 875-884(2018).

[20] T. Deffieux, Y. Younan, N. Wattiez, M. Tanter, P. Pouget, J. F. Aubry. Low-intensity focused ultrasound modulates monkey visuomotor behavior. Curr. Biol., 23, 2430-2433(2013).

[21] L. Verhagen, C. Gallea, D. Folloni, C. Constans, D. E. A. Jensen, H. Ahnine, L. Roumazeilles, M. Santin, B. Ahmed, S. Lehericy, M. C. Klein-Flügge, K. Krug, R. B. Mars, M. F. S. Rushworth, P. Pouget, J. F. Aubry, J. Sallet. Offline impact of transcranial focused ultrasound on cortical activation in primates. Elife, 8, e40541(2019).

[22] A. Abrahao, Y. Meng, M. Llinas, Y. X. Huang, C. Hamani, T. Mainprize, I. Aubert, C. Heyn, S. E. Black, K. Hynynen, N. Lipsman, L. Zinman. First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound. Nat. Commun., 10, 4373(2019).

[23] R. Beisteiner, E. Matt, C. Fan, H. Baldysiak, M. Schönfeld, T. P. Novak, A. Amini, T. Aslan, R. Reinecke, J. Lehrner, A. Weber, U. Reime, C. Goldenstedt, E. Marlinghaus, M. Hallett, H. Lohse-Busch. Transcranial pulse stimulation with ultrasound in Alzheimer’s Disease-A new navigated focal brain therapy. Adv. Sci., 7, 1902583(2020).

[24] Y. Meng, M. Volpini, S. Black, A. M. Lozano, K. Hynynen, N. Lipsman. Focused ultrasound as a novel strategy for Alzheimer disease therapeutics. Ann. Neurol., 81, 611-617(2017).

[25] H. Hakimova, S. Kim, K. Chu, S. K. Lee, B. Jeong, D. Jeon. Ultrasound stimulation inhibits recurrent seizures and improves behavioral outcome in an experimental model of mesial temporal lobe epilepsy. Epilepsy Behav., 49, 26-32(2015).

[26] S. J. Tsai. Transcranial focused ultrasound as a possible treatment for major depression. Med. Hypotheses, 84, 381-383(2015).

[27] R. Martínez-Fernández, R. Rodriguez-Rojas, M. del Alamo, F. Hernández-Fernández, J. A. Pineda-Pardo, M. Dileone, F. Alonso-Frech, G. Foffani, I. Obeso, C. Gasca-Salas, E. de Luis-Pastor, L. Vela, J. A. Obeso. Focused ultrasound subthalamotomy in patients with asymmetric Parkinson’s disease: A pilot study. Lancet Neurol., 17, 54-63(2018).

[28] G. Foffani, I. Trigo-Damas, J. A. Pineda-Pardo, J. Blesa, R. Rodríguez-Rojas, R. Martínez-Fernández, J. A. Obeso. Focused ultrasound in Parkinson’s disease: A twofold path toward disease modification. Movement Disord., 34, 1262-1273(2019).

[29] P. Fishman, N. Lipsman. Focused ultrasound as an evolving therapy for Parkinson’s disease. Movement Disord., 34, 1241-1242(2019).

[30] C. H. Fan, K. C. Wei, N. H. Chiu, E. C. Liao, H. C. Wang, R. Y. Wu, Y. J. Ho, H. L. Chan, T. S. A. Wang, Y. Z. Huang, T. H. Hsieh, C. H. Lin, Y. C. Lin, C. K. Yeh. Sonogenetic-based neuromodulation for the amelioration of Parkinson’s disease. Nano. Lett., 21, 5967-5976(2021).

[31] G. Leinenga, C. Langton, R. Nisbet, J. Götz. Ultrasound treatment of neurological diseases - current and emerging applications. Nat. Rev. Neurol., 12, 161-174(2016).

[32] W. Legon, A. Rowlands, A. Opitz, T. F. Sato, W. J. Tyler. Pulsed ultrasound differentially stimulates somatosensory circuits in humans as indicated by EEG and fMRI. Plos One, 7, e51177(2012).

[33] M. A. Santos, S. K. Wu, M. Regenold, C. Allen, D. E. Goertz, K. Hynynen. Novel fractionated ultrashort thermal exposures with MRI-guided focused ultrasound for treating tumors with thermosensitive drugs. Sci. Adv., 6, eaba5684(2020).

[34] Y. M. Li, Y. Jiang, L. Lan, X. W. Ge, R. Cheng, Y. W. Zhan, G. Chen, L. L. Shi, R. Y. Wang, N. Zheng, C. Yang, J. X. Cheng. Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision. Light-Sci. Appl., 11, 321(2022).

[35] Q. W. Li, Z. Y. Liu, Y. Zhao, R. N. Zhao, M. Y. Fan, G. Zhang, M. Yu, P. Han. A portable microwave intracranial hemorrhage imaging system based on PSO-MCKD-CEEMDAN Method. IEEE Trans. Microw. Theory, 71, 773-783(2023).

[37] C. G. A. Hoelen, F. F. M. de Mul. Image reconstruction for photoacoustic scanning of tissue structures. Appl. Opt., 39, 5872-5883(2000).

[38] C. K. Kuhl, S. Schrading, K. Strobel, H. H. Schild, R. D. Hilgers, H. B. Bieling. Abbreviated breast magnetic resonance imaging (MRI): First postcontrast subtracted images and maximum-intensity projection-A novel approach to breast cancer screening with MRI. J. Clin. Oncol., 32, 2304-2310(2014).

[39] W. A. Chao, W. Z. Qi, Y. B. Gong, Q. Liu, L. Xi. Electromagnetic wave-induced vectorial thermoacoustic bioimaging. IEEE Trans. Microw. Theory, 72, 1266-1279(2024).

[40] M. A. O’Reilly. Exploiting the mechanical effects of ultrasound for noninvasive therapy. Science, 385, eadp7206(2024).

[41] X. D. Hou, Z. H. Qiu, Q. X. Xian, S. Kala, J. N. Jing, K. F. Wong, J. J. Zhu, J. H. Guo, T. Zhu, M. Y. Yang, L. Sun. Precise ultrasound neuromodulation in a deep brain region using nano gas vesicles as actuators. Adv. Sci., 8, 2101934(2021).

[42] X. D. Hou, J. N. Jing, Y. Z. Jiang, X. H. Huang, Q. X. Xian, T. Lei, J. J. Zhu, K. F. Wong, X. Y. Zhao, M. Su, D. N. Li, L. Z. Liu, Z. H. Qiu, L. Sun. Nanobubble-actuated ultrasound neuromodulation for selectively shaping behavior in mice. Nat. Commun., 15, 2253(2024).

[43] X. Pan, L. S. Zeng, Y. Li, X. F. Zhu, Y. B. Jin. Experimental demonstration of Fresnel zone plate lens for robust subwavelength focusing at mega hertz. Ultrasonics, 128, 106876(2023).

[44] Q. Liu, X. Liang, T. T. Li, W. A. Chao, W. Z. Qi, T. Jin, Y. B. Gong, H. B. Jiang, L. Xi. Split ring resonator topology based microwave induced thermoacoustic imaging (SRR-MTAI). IEEE Trans. Med. Imaging, 42, 2425-2438(2023).

[45] M. Y. Ren, Z. W. Cheng, L. H. Wu, H. M. Zhang, S. X. Zhang, X. Y. Chen, D. Xing, H. Qin. Portable microwave-acoustic coaxial thermoacoustic probe with miniaturized vivaldi antennas for breast tumor screening. IEEE Trans. Bio-Med. Eng., 70, 175-181(2023).

[46] W. L. Luo, Z. Ji, S. H. Yang, D. Xing. Microwave-pumped electric-dipole resonance absorption for noninvasive functional imaging. Phys. Rev. Appl., 10, 024044(2018).

[47] X. B. Liu, N. Kent, A. Ceballos, R. Streubel, Y. F. Jiang, Y. Chai, P. Y. Kim, J. Forth, F. Hellman, S. W. Shi, D. Wang, B. A. Helms, P. D. Ashby, P. Fischer, T. P. Russell. Reconfigurable ferromagnetic liquid droplets. Science, 365, 264-267(2019).

[48] M. B. Sano, C. B. Arena, M. R. DeWitt, D. Saur, R. V. Davalos. In-vitro bipolar nano- and microsecond electro-pulse bursts for irreversible electroporation therapies. Bioelectrochemistry, 100, 69-79(2014).

Tools

Get Citation

Copy Citation Text

Weian Chao, Ruyi Wen, Yubin Gong, Qiang Liu, Lei Xi. Implantable bio-chip for visible and controllable microwave-induced transcranial acoustic generation[J]. Journal of Innovative Optical Health Sciences, 2025, 18(5): 2550012

Download Citation

EndNote(RIS)BibTexPlain Text
Save article for my favorites
Paper Information

Category: Research Articles

Received: Dec. 24, 2024

Accepted: Mar. 4, 2025

Published Online: Aug. 27, 2025

The Author Email: Qiang Liu (liuq7@sustech.edu.cn), Lei Xi (xilei@sustech.edu.cn)

DOI:10.1142/S1793545825500129

Topics