[1] [1] HORN P, TACKE F. Metabolic reprogramming in liver fibrosis[J]. Cell Metabolism, 2024, 36(7): 1439-1455.

[2] [2] ASRANI S K, DEVARBHAVI H, EATON J,et al. Burden of liver diseases in the world[J]. Journal of Hepatology, 2019, 70(1): 151-171.

[13] [13] GUO Y W, GUO T T, HUANG C,et al. Combining T1rho and advanced diffusion MRI for noninvasively staging liver fibrosis: an experimental study in rats[J]. Abdominal Radiology, 2024, 49(6): 1881-1891.

[16] [16] CHEN L, GUO W Y, MAO C,et al. Liver fibrosis: pathological features, clinical treatment and application of therapeutic nanoagents[J]. Journal of Materials Chemistry B, 2024, 12(6): 1446-1466.

[17] [17] CHIRUMBOLO S, BJRKLUND G. Quercetin in the experimental liver fibrosis induced by carbon tetrachloride (CCl4)[J]. International Immunopharmacology, 2018, 55: 254-256.

[18] [18] BATUDELIGEN, HAN Z Q, CHEN H M,et al. Luteolin alleviates liver fibrosis in rat hepatic stellate cell HSC-T6: a proteomic analysis[J]. Drug Design, Development and Therapy, 2023, 17: 1819-1829.

[19] [19] ZHANG Y, ZHANG M, LI H,et al. Serum metabonomics study of the hepatoprotective effect of amarogentin on CCl4-induced liver fibrosis in mice by GC-TOF-MS analysis[J]. Journal of Pharmaceutical and Biomedical Analysis, 2018, 149: 120-127.

[21] [21] SHAMSAN E, ALMEZGAGI M, GAMAH M,et al. The role of PI3k/AKT signaling pathway in attenuating liver fibrosis: a comprehensive review[J]. Frontiers in Medicine, 2024, 11: 1389329.

[22] [22] TANG S, LI Y H, BAO Y Y,et al. Novel cytisine derivatives exert anti-liver fibrosis effect via PI3K/Akt/Smad pathway[J]. Bioorganic Chemistry, 2019, 90: 103032.

[23] [23] JI D, ZHAO Q, QIN Y W,et al. Germacrone improves liver fibrosis by regulating the PI3K/AKT/mTOR signalling pathway[J]. Cell Biology International, 2021, 45(9): 1866-1875.

[24] [24] TANG Y, ZHU Z S, LI M Y,et al. Lycorine relieves the CCl4-induced liver fibrosis mainly via the JAK2/STAT3 and PI3K/AKT signaling pathways[J]. Toxicology and Applied Pharmacology, 2024, 489: 117017.

[25] [25] MA Y C, BAO Y N, WU L F,et al. IL-8 exacerbates CCl4-induced liver fibrosis in human IL-8 expressing mice via the PI3K/Akt/HIF-1alpha pathway[J]. Molecular Immunology, 2022, 152: 111-122.

[26] [26] ZHAO Y C, LIU X L, DING C B,et al.Aronia melanocarpapolysaccharide ameliorates liver fibrosis through TGF-1-mediated the activation of PI3K/AKT pathway and modulating gut microbiota[J]. Journal of Pharmacological Sciences, 2022, 150(4): 289-300.