Journal of Infrared and Millimeter Waves, Volume. 39, Issue 5, 553(2020)

Study of in-vivo breast cancer in a subcutaneous xenograft mouse model using terahertz imaging

Li-Min WU1,2, Bin LIAO3, De-Gang XU1,2, Yu-Ye WANG1,2,3、*, Mei-Lan GE1,2, Chao-Nan ZHANG4, Jia-Hua LI4, Zhong-Cheng SUN1,2, Tu-Nan CHEN3, Hua FENG3, and Jian-Quan YAO1,2
Author Affiliations
  • 1Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin300072, China
  • 2Key Laboratory of Optoelectronics Information Technology (Ministry of Education), Tianjin University, Tianjin300072, China
  • 3Institute of Neurosurgery, Southwest Hospital, Army Medical University, Chongqing;400038, China
  • 4School of Life Sciences, Tianjin Engineering Center of Micro-Nano Biomaterials, Tianjin University, Tianjin300072, China
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    Breast cancer (BC) is one of the most common diseases in women. The accurate detection for BC is very important in clinical practice. In this paper, in-vivo breast cancer in a subcutaneous xenograft mouse was studied with the continuous-wave terahertz (THz) reflection imaging system at 2.52THz. The high reflection region in THz images of in-vivo subcutaneous xenograft mouse corresponded well to the tumor area in visible. The difference value of 15% between tumor and normal tissues was observed. For the gold standard, the tumor areas at different depths from the surface of skin in mouse model were obtained by hematoxylin and eosin-stained images. The tumor areas increased with the increase of depth. In contrast with THz image, it is found that the tumor area in THz image was similar to that in hematoxylin and eosin-stained images at a depth of 460μm. Therefore, the detection depth of THz wave to in-vivo breast cancer in subcutaneous xenograft mouse modelis about 460μm, and THz wave is expected to realize the detection of deep tumors.

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    Li-Min WU, Bin LIAO, De-Gang XU, Yu-Ye WANG, Mei-Lan GE, Chao-Nan ZHANG, Jia-Hua LI, Zhong-Cheng SUN, Tu-Nan CHEN, Hua FENG, Jian-Quan YAO. Study of in-vivo breast cancer in a subcutaneous xenograft mouse model using terahertz imaging[J]. Journal of Infrared and Millimeter Waves, 2020, 39(5): 553

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    Paper Information

    Category: Millimeter Wave and Terahertz Technology

    Received: Sep. 26, 2019

    Accepted: --

    Published Online: Dec. 29, 2020

    The Author Email: Yu-Ye WANG (yuyewang@tju.edu.cn)

    DOI:10.11972/j.issn.1001-9014.2020.05.004

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