In order to obtain welds with low porosity, complete melting of the glass frit, and good morphology, a mathematical model was established according to the Box-Behnken design principle in the response surface method to study the proportion of weld defects in the glass laser welding and the process parameters including pre-sintering peak temperature, laser power, welding speed, and defocus. Based on this model, the interactive influence trend of each process parameter on the proportion of weld defect area was analyzed, and then the process parameters were optimized. The experimental verification was carried out under the optimized conditions of pre-sintering peak temperature 440℃, laser power 37W, welding speed 0.1m/min, and defocusing distance 14.4mm.The results show that the sum of the pore area and the incomplete melting area of the frit accounts for only 0.512% of the total weld area under the optimized process parameters. The experimental results are consistent with the model predictions. The weld surface morphology is good, and the weld shear strength is 17.765MPa, which is higher than the standard value, indicating that the optimized process parameters under the model are reasonable.