Fig. 1. Schematic and experimental diagram. Laser (semiconductor laser, wavelength 635 nm, output power 0–100 mW); CCD (Balser acA-2440-75uc, resolution 2448 pixels × 2048 pixels); microscope (0.7× to 4.5×).

Fig. 2. Comparative results of the phantom experiments. (a)–(c) LSCI-IFM, stLASCA, and LSCI-uSTFT images. (A)–(C) Curves of the MD (LSCI-IFM), K (stLASCA), MD (LSCI-uSTFT) along the dashed line in (a)–(c).

Fig. 3. Comparative results of the in vivo experiments. (a) Normalized blood flow distribution of stLASCA; (b) LSCI-uSTFT image; (c) curves along the dashed line in (a) and (b).

Fig. 4. Comparative results of noise suppression ability with different methods. (a) Contrast image obtained by LSCI-uSTFT, where Area1–Area6 are six ROIs randomly selected; (b) comparison of CNR; (c) comparison of spatial noise.

Fig. 5. (a) MD (LSCI-uSTFT) image; (b) relationship between the MD and the reconstructed frame number; (c) MD (LSCI-uSTFT) images of blood flows reconstructed with 16, 32, 64, and 256 frames.

Fig. 6. Comparative results of the calculation time with LSCI-IFM, stLASCA, and LSCI-uSTFT.