Laboratory Animal and Comparative Medicine, Volume. 45, Issue 4, 393(2025)
Comparison of Histopathological and Molecular Pathological Phenotypes in Mouse Models of Intrauterine Adhesions Induced by Two Concentrations of Ethanol Perfusion
[2] [2] HAN Q X, DU Y Z. Advances in the application of biomimetic endometrium interfaces for uterine bioengineering in female infertility[J]. Front Bioeng Biotechnol, 2020, 8: 153. DOI: 10.3389/fbioe.2020.00153.
[3] [3] SANTAMARIA X, ISAACSON K, SIMN C. Asherman's syndrome: it may not be all our fault[J]. Hum Reprod, 2018, 33(8): 1374-1380. DOI: 10.1093/humrep/dey232.
[4] [4] ERSOY G S, ZOLBIN M M, COSAR E, et al. CXCL12 promotes stem cell recruitment and uterine repair after injury in Asherman's syndrome[J]. Mol Ther Methods Clin Dev, 2017, 4: 169-177. DOI: 10.1016/j.omtm.2017.01.001.
[5] [5] REIN D T, SCHMIDT T, HESS A P, et al. Hysteroscopic management of residual trophoblastic tissue is superior to ultrasound-guided curettage[J]. J Minim Invasive Gynecol, 2011, 18(6): 774-778. DOI: 10.1016/j.jmig.2011.08.003.
[6] [6] CAI Y L, WU F Y, YU Y R, et al. Porous scaffolds from droplet microfluidics for prevention of intrauterine adhesion[J]. Acta Biomater, 2019, 84: 222-230. DOI: 10.1016/j.actbio.2018.11.016.
[7] [7] KOU L F, JIANG X, XIAO S Y, et al. Therapeutic options and drug delivery strategies for the prevention of intrauterine adhesions[J]. J Control Release, 2020, 318: 25-37. DOI: 10.1016/j.jconrel.2019.12.007.
[10] [10] CAO Y M, QI J, WANG J, et al. Injectable "homing-like" bioactive short-fibers for endometrial repair and efficient live births[J]. Adv Sci, 2024, 11(20): e2306507. DOI: 10.1002/advs.202306507.
[11] [11] QI J, LI X X, CAO Y M, et al. Locationally activated PRPviaan injectable dual-network hydrogel for endometrial regeneration[J]. Biomaterials, 2024, 309: 122615. DOI: 10.1016/j.biomaterials.2024.122615.
[12] [12] HUA Q, ZHANG Y, LI H J, et al. Human umbilical cord blood-derived MSCs trans-differentiate into endometrial cells and regulate Th17/Treg balance through NF-B signaling in rabbit intrauterine adhesions endometrium[J]. Stem Cell Res Ther, 2022, 13(1): 301. DOI: 10.1186/s13287-022-02990-1.
[13] [13] LIANG Y X, SHUAI Q Z, ZHANG X, et al. Incorporation of decidual stromal cells derived exosomes in sodium alginate hydrogel as an innovative therapeutic strategy for advancing endometrial regeneration and reinstating fertility[J]. Adv Healthc Mater, 2024, 13(13): e2303674. DOI: 10.1002/adhm.202303674.
[14] [14] ZHANG S H, SUN Y L, JIANG D L, et al. Construction and optimization of an endometrial injury model in mice by transcervical ethanol perfusion[J]. Reprod Sci, 2021, 28(3): 693-702. DOI: 10.1007/s43032-020-00296-2.
[15] [15] LIANG S S, HUANG Y L, XIA Y F, et al. Animal models in intrauterine adhesion research[J]. J Obstet Gynaecol, 2022, 42(8): 3409-3415. DOI: 10.1080/01443615.2022.2124854.
[16] [16] LI B N, ZHANG Q W, SUN J Y, et al. Human amniotic epithelial cells improve fertility in an intrauterine adhesion mouse model[J]. Stem Cell Res Ther, 2019, 10(1): 257. DOI: 10.1186/s13287-019-1368-9.
[17] [17] PARK M, HONG S H, PARK S H, et al. Perivascular stem cell-derived cyclophilin A improves uterine environment with Asherman's syndromeviaHIF1-dependent angiogenesis[J]. Mol Ther, 2020, 28(8): 1818-1832. DOI: 10.1016/j.ymthe.2020.05.015.
[19] [19] LEE W L, LIU C H, CHENG M, et al. Focus on the primary prevention of intrauterine adhesions: current concept and vision[J]. Int J Mol Sci, 2021, 22(10): 5175. DOI: 10.3390/ijms22105175.
[20] [20] DAI Y Y, XIN L B, HU S T, et al. A construct of adipose-derived mesenchymal stem cells-laden collagen scaffold for fertility restoration by inhibiting fibrosis in a rat model of endometrial injury[J]. Regen Biomater, 2023, 10: rbad080. DOI: 10.1093/rb/rbad080.
[21] [21] TANG P M, NIKOLIC-PATERSON D J, LAN H Y. Macrophages: versatile players in renal inflammation and fibrosis[J]. Nat Rev Nephrol, 2019, 15(3): 144-158. DOI: 10.1038/s41581-019-0110-2.
[22] [22] LIU F, ZHU Z J, LI P, et al. Creation of a female rabbit model for intrauterine adhesions using mechanical and infectious injury[J]. J Surg Res, 2013, 183(1): 296-303. DOI: 10.1016/j.jss.2012.11.009.
[23] [23] XU X X, ZHANG S S, LIN H L, et al. Metformin promotes regeneration of the injured endometriumviainhibition of endoplasmic reticulum stress-induced apoptosis[J]. Reprod Sci, 2019, 26(4): 560-568. DOI: 10.1177/1933719118804424.
[24] [24] WEN J M, HOU B, LIN W G, et al. 3D-printed hydrogel scaffold-loaded granulocyte colony-stimulating factor sustained-release microspheres and their effect on endometrial regeneration[J]. Biomater Sci, 2022, 10(12): 3346-3358. DOI: 10.1039/d2bm00109h.
[25] [25] JANG H Y, MYOUNG S M, CHOE J M, et al. Effects of autologous platelet-rich plasma on regeneration of damaged endometrium in female rats[J]. Yonsei Med J, 2017, 58(6): 1195-1203. DOI: 10.3349/ymj.2017.58.6.1195.
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JIANG Juan, SONG Ning, LIAN Wenbo, SHAO Congcong, GU Wenwen, SHI Yan. Comparison of Histopathological and Molecular Pathological Phenotypes in Mouse Models of Intrauterine Adhesions Induced by Two Concentrations of Ethanol Perfusion[J]. Laboratory Animal and Comparative Medicine, 2025, 45(4): 393
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Received: Dec. 6, 2024
Accepted: Sep. 10, 2025
Published Online: Sep. 10, 2025
The Author Email: SHI Yan (shiyan1981@126.com)