Chinese Journal of Pharmaceuticals, Volume. 56, Issue 7, 929(2025)

Optimization of Extraction and Purification Process of Total Alkaloids from Chelidonium and in vitro Antitumor Activity

SUN Lin1, LI Tianjiao1,2,3, YANG Xinxin1,2,3, BAO Yongrui1,2,3、*, WANG Shuai1,2,3, and MENG Xiansheng1,2,3
Author Affiliations
  • 1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600
  • 2Professional Innovation Technology Center for Multidimensional Analysis of Traditional Chinese Medicine, Dalian 116600
  • 3Liaoning Province Modern Chinese Medicine Research Engineering Lab., Dalian 116600
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    References(3)

    [2] [2] ZIELINSKA S, JEZIERSKA-DOMARADZKA A, WOJCIAK-KOSIOR M,et al. Greater Celandine’s ups and downs-21 centuries of medicinal uses ofChelidonium majusfrom the viewpoint of today’s pharmacology [J].Front Pharmacol, 2018,9: 299.

    [3] [3] DELJANIN M, NIKOLIC M, BASKIC D,et al. Chelidonium majus crude extract inhibits migration and induces cell cycle arrest and apoptosis in tumor cell lines [J].Ethnopharmacol, 2016,190: 362-371.

    [13] [13] LI C, DONG N, WU B,et al. Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice [J].Phytomedicine, 2021,90: 153631.

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    SUN Lin, LI Tianjiao, YANG Xinxin, BAO Yongrui, WANG Shuai, MENG Xiansheng. Optimization of Extraction and Purification Process of Total Alkaloids from Chelidonium and in vitro Antitumor Activity[J]. Chinese Journal of Pharmaceuticals, 2025, 56(7): 929

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    Paper Information

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    Received: Oct. 24, 2024

    Accepted: Aug. 26, 2025

    Published Online: Aug. 26, 2025

    The Author Email: BAO Yongrui (byr1026@163.com)

    DOI:10.16522/j.cnki.cjph.2025.07.012

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