Chinese Journal of Lasers, Volume. 50, Issue 21, 2107105(2023)

Laser-Generated Ultrasound Technology and Its Application

Lei Wang1, Lin Li1, Yongwen Zhao1, Dinglong Ma1, Ying Gu2、**, and Pu Wang1、*
Author Affiliations
  • 1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
  • 2Department of Laser Medicine, the First Medical Center, PLA General Hospital, Beijing 100853, China
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    Figures & Tables(13)
    Typical structures of piezoelectric ultrasonic transducers and different kinds of laser-generated ultrasound transducers. (a) Typical structure of piezoelectric ultrasonic transducer[96]; (b) laser-generated ultrasound transducer based on fiber with scale bar of 50 μm[80]; (c) structural diagram of omnidirectional laser-generated ultrasound transducer[110]; (d) omni-directional laser-generated ultrasound transducers used to generate omni-directional ultrasound[110]
    Frequency domain distributions of laser with different pulse widths
    Influence of thickness of laser-generated ultrasound transducer on laser-generated ultrasound pulse[59]. (a) Schematics of laser acting on laser-generated ultrasound transducers with different thicknesses; (b) schematics of determining laser-generated ultrasound pulses of laser-generated ultrasound transducers with different thickness by convolution integral
    Time domain and frequency domain information under different laser pulse widths and material thicknesses. (a) Schematic of laser-generated ultrasound system[115]; (b) frequency domain distribution of 10 μm diameter black microsphere under excitation with different laser pulse durations[115]; (c) time domain distribution of laser-generated ultrasound[115]; (d) reconstructed image of 10 μm diameter microsphere obtained by laser-generated ultrasound method[115]; (e) sound pressures and spectra of samples with different deposition time (10, 30, 120 s) obtained under low laser energy input[89]
    Distribution of sound field of laser-generated ultrasound transducer. (a) Simulated sound field distribution generated by planar ultrasound[72]; (b) experimental sound field distribution generated by planar ultrasound[119]; (c) simulated sound field distribution generated by focusing ultrasound[54]; (d) schematic of focusing ultrasonic transducer generation[75]; (e) sound field distribution of omnidirectional ultrasound[124]
    Transcranial stimulation in vitro by OFUS[75]. (a) Schematic of transcranial stimulation in vitro; (b) representative images of neurons before and after transcranial stimulation with scale bar of 50 μm; (c) averaged calcium response trace of transcranial OFUS stimulation; (d) statistics of threshold pressure of direct and transcranial stimulation in single cycle
    Imaging by ultra-wide bandwidth AO-IVUS[54]. (a) Imaging diagram of vessel wall by AO-IVUS; (b) power spectrum of AO-IVUS catheter ultrasound response; (c) 2D cross-sectional image acquired by AO-IVUS; (d) 3D ultrasound data of arterial wall by rotation-pullback scan with AO-IVUS
    Micro-scale fragmentation of solid materials by LGFU[109]. (a) Model of kidney stone with scale bar of 4 mm; (b) single micro-hole on polymer film produced by single LGFU pulse with scale bar of 20 μm; (c)(d) high-speed microscopic images of fragmentation process on polymer-coated glass substrate
    Targeted cell removal by LGFU with scale bar of 520 mm[95]. (a) Cultured ovarian cancer cells (SKOV3) before ultrasound exposure; (b) selective removal of single cell after LGFU exposure; (c) cellular interconnection is severed when LGFU spot is moved to black dot region
    Locating and removal of tumor using FOG and AR system[124]. (a) Principle diagram; (b) photograph of compact integrated system on cart; (c) visualization of FOG tip in breast of human sample
    Fiber optoacoustic guide for tumor localization with sub-millimeter accuracy[111]. (a) Photographs of fiber optoacoustic guide, zinc oxide nanoparticles, and epoxy; (b) signal-to-noise ratio of generated optoacoustic signal from FOG tip at different angles; (c) representative optoacoustic signal waveform recorded at 8 cm away from FOG tip in forward direction; (d) frequency spectrum of representative optoacoustic signal waveform after normalization of detector response; (e) signal-to-noise ratio of generated optoacoustic signal after passing chicken breast tissues with different thicknesses
    Shadowgraph images at air-water interface with scale bar of 100 μm[164]. (a) Water micro-jets; (b) bubbles
    • Table 1. Summary of different types of laser-generated ultrasound transducers

      View table

      Table 1. Summary of different types of laser-generated ultrasound transducers

      MaterialPulsed width of laserThicknessCenter frequencyBandwidthReference
      Au100 fs15 nm4.8‒9.0 GHz88
      Au1.4 ns250 nm65.1 MHz108.8 MHz66
      CNT-PDMS6 ns~800 nm61
      MWCNTs-PDMS2 ns~20 μm~ 28.5 MHz39.8 MHz80
      MAPbI3-PDMS6 ns~5 μm~ 29.2 MHz40.8 MHz72
      CB-PDMS8 ns2.7 μm15 MHz30 MHz75
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    Lei Wang, Lin Li, Yongwen Zhao, Dinglong Ma, Ying Gu, Pu Wang. Laser-Generated Ultrasound Technology and Its Application[J]. Chinese Journal of Lasers, 2023, 50(21): 2107105

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    Paper Information

    Category: Biomedical Optical Imaging

    Received: Apr. 12, 2023

    Accepted: May. 25, 2023

    Published Online: Nov. 1, 2023

    The Author Email: Ying Gu (guyinglaser301@163.com), Pu Wang (10318@buaa.edu.cn)

    DOI:10.3788/CJL230708

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