Advanced Photonics, Volume. 3, Issue 2, 026004(2021)

Multiscale label-free volumetric holographic histopathology of thick-tissue slides with subcellular resolution

Herve Hugonnet1,2, Yeon Wook Kim3, Moosung Lee1,2, Seungwoo Shin1,2, Ralph H. Hruban4, Seung-Mo Hong4,5、*, and YongKeun Park1,2,6、*
Author Affiliations
  • 1Korea Advanced Institute of Science and Technology, Department of Physics, Daejeon, Republic of Korea
  • 2KAIST Institute for Health Science and Technology, KAIST, Daejeon, Republic of Korea
  • 3Asan Institute for Life Science, Asan Medical Center, Seoul, Republic of Korea
  • 4Johns Hopkins Medical Institutions, Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Baltimore, Maryland, United States
  • 5University of Ulsan College of Medicine, Asan Medical Center, Department of Pathology, Seoul, Republic of Korea
  • 6Tomocube Inc., Daejeon, Republic of Korea
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    [4] J. I. Hamburger et al. Increasing the accuracy of fine-needle biopsy for thyroid nodules. Arch. Pathol. Lab. Med., 113, 1035-1041(1989).

    [28] E. Wolf, M. Born. Scattering from inhomogeneous media. Principles of Optics: Electromagnetic Theory of Propagation, Interference and Diffraction of Light, 695-734(1999).

    [33] A. Goy et al. Imaging thick samples with optical tomography(2017).

    [38] D. Ryu et al. DeepRegularizer: rapid resolution enhancement of tomographic imaging using deep learning(2020).

    [44] D. C. Ghiglia, M. D. Pritt. Two-Dimensional Phase Unwrapping: Theory, Algorithms, and Software(1998).

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    Herve Hugonnet, Yeon Wook Kim, Moosung Lee, Seungwoo Shin, Ralph H. Hruban, Seung-Mo Hong, YongKeun Park, "Multiscale label-free volumetric holographic histopathology of thick-tissue slides with subcellular resolution," Adv. Photon. 3, 026004 (2021)

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    Paper Information

    Category: Research Articles

    Received: Nov. 4, 2020

    Accepted: Mar. 23, 2021

    Posted: Mar. 23, 2021

    Published Online: May. 6, 2021

    The Author Email: Hong Seung-Mo (smhong28@gmail.com), Park YongKeun (yk.park@kaist.ac.kr)

    DOI:10.1117/1.AP.3.2.026004

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