Fig. 1. Schematic diagrams of SIM and oblique illumination principle. (a) Schematic diagram of SIM principle; (b) schematic diagram of oblique illumination principle

Fig. 2. Experimental setup for SIM-ROCS imaging system

Fig. 3. System resolution measurement. (a) The FWHM of single microsphere under different modes; (b) image of microspheres and its spectrum under ROCS mode

Fig. 4. ROCS imaging results. (a) Imaging results of 200nm fluorescent microspheres under three modes; (b) the itensity distribution of ROI under three modes; (c) comparison of contrast between ROCS and wide-field fluorescence modes

Fig. 5. PANC-1 pancreatic cancer cell imaging results. (a) Imaging results of PANC-1 sample under wide-field fluorescence and ROCS mode; (b) the intensity distribution of images along straight lines under two modes