Rapid Qualitative and Quantitative Detection of Warfarin Sodium Based on Terahertz Spectroscopy

Jing Wu; Xu Wu; Xinghao Huang; Jiawei Li; Jinjing Zhang; Yan Peng; Lin Lu

doi:10.3788/CJL231422

Chinese Journal of Lasers, Volume. 51, Issue 3, 0307206(2024)

Rapid Qualitative and Quantitative Detection of Warfarin Sodium Based on Terahertz Spectroscopy

Jing Wu¹, Xu Wu^2、*, Xinghao Huang², Jiawei Li², Jinjing Zhang², Yan Peng², and Lin Lu³

Author Affiliations

¹College of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

²School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

³Department of Cardiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

show less

Abstract Get PDF(in Chinese)

Figures & Tables(7)

Fig. 1. Terahertz absorption characteristics of warfarin sodium. (a) Frequency domain diagram with schematic of detection shown in inset; (b) terahertz absorption spectra of warfarin sodium

Download full size

Fig. 2. Theoretical simulation results of warfarin molecules. (a) Molecular model of warfarin sodium; (b) molecular model of warfarin; (c) theoretical spectrum of warfarin and experimental spectrum of warfarin sodium

Download full size

Fig. 3. Vibrational modes of warfarin at different theoretical peak positions, in which arrow presents vibration direction and length of arrow presents intensity of vibration. (a) 11.07 THz; (b) 11.70 THz; (c) 13.28 THz; (d) 13.82 THz; (e) 14.27 THz; (f) 15.71 THz

Download full size

Fig. 4. Terahertz absorption spectra of warfarin sodium solutions with different concentrations. (a) Before baseline removal; (b) after baseline removal

Download full size

Fig. 5. Relationship between THz characteristic peak and warfarin sodium concentration. (a) Relationship between concentration and peak height; (b) relationship between concentration and peak area

Download full size

Table 1. Comparison between theoretical peaks and measured peaks as well as corresponding molecular motions

View table

Table 1. Comparison between theoretical peaks and measured peaks as well as corresponding molecular motions

Theoretical peak /THz	Measured peak /THz	Deviation /THz	Molecular motion
11.07	11.10	-0.03	Twisting （—C9H5O3） + twising （—Ph） + rocking （—CH3）
11.70	11.94	-0.24	Twisting （—CO—） + twising （CO）
13.28	13.14	0.14	Twisting （—Ph） + deformation （—CH3）
13.82	13.74	0.08	Twisting （—C9H5O3）
14.27	14.01	0.26	Twisting （—C9H5O3）
15.71	15.43	0.28	Rocking （—CH2—） + deformation （—CH3）

Table 2. Detection performances of double-index quantitative analysis method for warfarin sodium based on terahertz spectroscopy
View table
Table 2. Detection performances of double-index quantitative analysis method for warfarin sodium based on terahertz spectroscopy
Peak position /THz Based on peak height Based on peak area
$δ$ $S$ LOD /（nmol/mL） $δ$ $S$ LOD /（nmol/mL）
12.10 0.0059 1.10 0.02 0.0037 0.60 0.02
13.79 0.0077 1.58 0.02 0.0035 1.05 0.01
15.58 0.0027 0.79 0.01 0.0026 0.71 0.01

Tools

Get Citation

Copy Citation Text

Jing Wu, Xu Wu, Xinghao Huang, Jiawei Li, Jinjing Zhang, Yan Peng, Lin Lu. Rapid Qualitative and Quantitative Detection of Warfarin Sodium Based on Terahertz Spectroscopy[J]. Chinese Journal of Lasers, 2024, 51(3): 0307206

Download Citation

EndNote(RIS)BibTex Plain Text

Set citation alerts for article

Save article for my favorites

Paper Information

Category: Optical Diagnostics and Therapy

Received: Nov. 22, 2023

Accepted: Jan. 8, 2024

Published Online: Feb. 19, 2024

The Author Email: Wu Xu (wuxu@usst.edu.cn)

DOI:10.3788/CJL231422

CSTR:32183.14.CJL231422

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Comparison between theoretical peaks and measured peaks as well as corresponding molecular motions

Table 1. Comparison between theoretical peaks and measured peaks as well as corresponding molecular motions

Table 2. Detection performances of double-index quantitative analysis method for warfarin sodium based on terahertz spectroscopy

Table 2. Detection performances of double-index quantitative analysis method for warfarin sodium based on terahertz spectroscopy