Acta Optica Sinica, Volume. 45, Issue 4, 0430001(2025)

Real-Time Detection of Metabolic Carbon Dioxide Volume Fraction in Skin Based on Frequency-Locked Quartz-Enhanced Photoacoustic Spectroscopy

Yixin Zhang1, Huakun Wu1, Qiong Wu1, Wen Liu1,2, and Jie Shao1,2、*
Author Affiliations
  • 1College of Physics and Electronic Engineering, Zhejiang Normal University, Jinhua 321004, Zhejiang , China
  • 2Institute of Optoelectronics, Zhejiang Normal University, Jinhua 321004, Zhejiang , China
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    Figures & Tables(13)
    Simulation of absorption spectra of CO2 and interfering gases at air volume fraction
    Schematic diagram of detection system
    Temperature change in detection chamber under skin fit. (a) Results without temperature control; (b) results under temperature control
    Physical device diagram of the skin CO2 detection system based on QEPAS technology. (a) Equipment; (b) sample absorption pool; (c) detection chamber; (d) analog PID control circuit; (e) temperature controlled circuit
    Signals of the first harmonic frequency locking system. (a) Locking process of the first harmonic signal of the sample absorption cell; (b) second harmonic signal of QTF
    Gas distribution system
    Test results of system response time. (a) Second harmonic signal response curve for variation of CO2 volume fraction from 0 to 2000×10-6; (b) results of exponential fitting of the volume fraction change process
    Linear analysis of the system
    Allen analysis of variance
    Schematic diagram of skin detection. (a) Detection site; (b) detection method
    Results of the skin CO2 detection by the system on the left arm, left palm, left cheek, and left armpit with linear fitting results for the four sites
    Linear fit results obtained from four identical sites of skin CO2 testing on two adjacent days for the same volunteer
    Schematic diagram of human detection sites and statistical results of CO2 release rates from four sites in three volunteers
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    Yixin Zhang, Huakun Wu, Qiong Wu, Wen Liu, Jie Shao. Real-Time Detection of Metabolic Carbon Dioxide Volume Fraction in Skin Based on Frequency-Locked Quartz-Enhanced Photoacoustic Spectroscopy[J]. Acta Optica Sinica, 2025, 45(4): 0430001

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    Paper Information

    Category: Spectroscopy

    Received: Nov. 5, 2024

    Accepted: Dec. 10, 2024

    Published Online: Feb. 19, 2025

    The Author Email: Shao Jie (shaojie@zjnu.cn)

    DOI:10.3788/AOS241710

    CSTR:32393.14.AOS241710

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