Quantitative Phase Imaging Based on Transport-of-Intensity Equation and Differential Interference Contrast Microscope and Its Application in Breast Cancer Diagnosis

Cai Shuangshuang; Zheng Longfei; Zeng Bixin; Li Run; Xu Min

doi:10.3788/CJL201845.0307015

Chinese Journal of Lasers, Volume. 45, Issue 3, 307015(2018)

Quantitative Phase Imaging Based on Transport-of-Intensity Equation and Differential Interference Contrast Microscope and Its Application in Breast Cancer Diagnosis

Cai Shuangshuang^1,2, Zheng Longfei^1,2, Zeng Bixin^1,2, Li Run³, and Xu Min^2,4、*

Author Affiliations

¹[in Chinese]

²[in Chinese]

³[in Chinese]

⁴[in Chinese]

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Figures & Tables(6)

Fig. 1. Phase map of monolayer polystyrene sphere (diameter of 10 μm) suspension

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Fig. 2. Imaging results of invasive ductal carcinoma tissues. (a) Grade 1; (b) grade 3

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Fig. 3. Histograms of scattering coefficient, reduced scattering coefficient, and anisotropy of invasive ductal carcinoma tissues with different cancer grades. (a) Grade 1; (b) grade 2; (c) grade 3

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Table 1. Experimental and theoretical values of scatteringparameters of polystyrene sphere (diameter of 10 μm)
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Table 1. Experimental and theoretical values of scatteringparameters of polystyrene sphere (diameter of 10 μm)
Parameter Experimentalvalue Theoreticalvalue Relativeerror /%
μ_s /μm^-1 0.2211 0.2297 3.7
μ'_s /μm^-1 0.0204 0.0210 2.9
g 0.9077 0.9086 0.1

Table 2. Experimental results of scattering coefficient,reduced scattering coefficient, and anisotropy of tissue sections from 257 cases with invasive ductal carcinoma tissues
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Table 2. Experimental results of scattering coefficient,reduced scattering coefficient, and anisotropy of tissue sections from 257 cases with invasive ductal carcinoma tissues
Grade μ_s /μm^-1 μ'_s /μm^-1 g
1 0.3814 (0.0204) 0.0160 (0.0063) 0.9584 (0.0154)
2 0.3961 (0.0072) 0.0279 (0.0059) 0.9297 (0.0147)
3 0.3968 (0.0073) 0.0510 (0.0173) 0.8716 (0.0435)

Table 3. Comparison of diagnosis results of invasive ductal carcinoma given by SVM and pathological diagnosis
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Table 3. Comparison of diagnosis results of invasive ductal carcinoma given by SVM and pathological diagnosis
Pathology result Predicting result based on SVM Predicting accuracy /%
Grade Case number Grade 1 Grade 2 Grade 3
1 17 13 4 0 76.5
2 19 0 18 1 94.7
3 14 0 1 13 92.9

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Cai Shuangshuang, Zheng Longfei, Zeng Bixin, Li Run, Xu Min. Quantitative Phase Imaging Based on Transport-of-Intensity Equation and Differential Interference Contrast Microscope and Its Application in Breast Cancer Diagnosis[J]. Chinese Journal of Lasers, 2018, 45(3): 307015

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Paper Information

Special Issue:

Received: Aug. 15, 2017

Accepted: --

Published Online: Mar. 6, 2018

The Author Email: Min Xu (mxu@fairfield.edu)

DOI:10.3788/CJL201845.0307015

Topics

laser devices and laser physics

Lasers and Laser Optics

Laser physics

laser manufacturing

Instrumentation, Measurement and Metrology

Table 1. Experimental and theoretical values of scatteringparameters of polystyrene sphere (diameter of 10 μm)

Table 1. Experimental and theoretical values of scatteringparameters of polystyrene sphere (diameter of 10 μm)

Table 2. Experimental results of scattering coefficient,reduced scattering coefficient, and anisotropy of tissue sections from 257 cases with invasive ductal carcinoma tissues

Table 2. Experimental results of scattering coefficient,reduced scattering coefficient, and anisotropy of tissue sections from 257 cases with invasive ductal carcinoma tissues

Table 3. Comparison of diagnosis results of invasive ductal carcinoma given by SVM and pathological diagnosis

Table 3. Comparison of diagnosis results of invasive ductal carcinoma given by SVM and pathological diagnosis