Chinese Journal Of Clinical Medicine, Volume. 32, Issue 3, 441(2025)

The correlation between abnormal metabolic indexes and the severity of coronary artery lesions in patients with acute coronary syndrome

ZHAO Yajun1, LIU Ming1, DAI Yuxiang2, LI Xiaopan1, CHENG Xuelin3, WANG Qizhe1, LIU Ru1, XU Yaxin3, and JIANG Sunfang1,3、*
Author Affiliations
  • 1Health Management Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China
  • 2Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
  • 3Department of General Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
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    References(18)

    [1] [1] BHATT D L, LOPES R D, HARRINGTON R A. Diagnosis and treatment of acute coronary syndromes: a review[J]. JAMA, 2022, 327(7): 662-675.

    [3] [3] ISEZUO S, SANI M U, TALLE A, et al. Registry for acute coronary events in Nigeria (RACE-Nigeria): clinical characterization, management, and outcome[J]. J Am Heart Assoc, 2022, 11(1): e020244.

    [5] [5] LI M N, WANG H J, ZHANG N R, et al. MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome[J]. Medicine (Baltimore), 2017, 96(49): e9044.

    [10] [10] CIMMINO G, GALLINORO E, DI SERAFINO L, et al. Uric acid plasma levels are associated with C-reactive protein concentrations and the extent of coronary artery lesions in patients with acute coronary syndromes[J]. Intern Emerg Med, 2023, 18(6): 1751-1757.

    [12] [12] REARDON M F, NESTEL P J, CRAIG I H, et al. Lipoprotein predictors of the severity of coronary artery disease in men and women[J]. Circulation, 1985, 71(5): 881-888.

    [14] [14] MOHILE S, BLAUM C S, ABADIR P M, et al. AGS and NIA bench-to bedside conference summary: cancer and cardiovascular disease[J]. J Am Geriatr Soc, 2022, 70(10): 2764-2774.

    [15] [15] YU T T, LUO D, LUO C C, et al. Prognostic and therapeutic value of serum lipids and a new IPI score system based on apolipoprotein A-I in diffuse large B-cell lymphoma[J]. Am J Cancer Res, 2023, 13(2): 475-484.

    [17] [17] ZHENG W C, CHAN W, DART A, et al. Novel therapeutic targets and emerging treatments for atherosclerotic cardiovascular disease[J]. Eur Heart J Cardiovasc Pharmacother, 2024, 10(1): 53-67.

    [18] [18] LIBBY P, BURING J E, BADIMON L, et al. Atherosclerosis[J]. Nat Rev Dis Primers, 2019, 5(1): 56.

    [19] [19] GENCER B, MARSTON N A, IM K, et al. Efficacy and safety of lowering LDL cholesterol in older patients: a systematic review and meta-analysis of randomised controlled trials[J]. Lancet, 2020, 396(10263): 1637-1643.

    [21] [21] KHAN A W, JANDELEIT-DAHM K A M. Atherosclerosis in diabetes mellitus: novel mechanisms and mechanism-based therapeutic approaches[J]. Nat Rev Cardiol, 2025.

    [22] [22] WANG X, YU D H, WANG J R, et al. Analysis of coronary artery lesion degree and related risk factors in patients with coronary heart disease based on computer-aided diagnosis of coronary angiography[J]. Comput Math Methods Med, 2021, 2021: 2370496.

    [24] [24] GRECO A, FINOCCHIARO S, SPAGNOLO M, et al. Lipoprotein(a) as a pharmacological target: premises, promises, and prospects[J]. Circulation, 2025, 151(6): 400-415.

    [25] [25] SINGH S S, VAN DER TOORN J E, SIJBRANDS E J G, et al. Lipoprotein(a) is associated with a larger systemic burden of arterial calcification[J]. Eur Heart J Cardiovasc Imaging, 2023, 24(8): 1102-1109.

    [27] [27] VIEGAS C S B, SANTOS L, MACEDO A L, et al. Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: a role for GRP (gla-rich protein)[J]. Arterioscler Thromb Vasc Biol, 2018, 38(3): 575-587.

    [28] [28] THEODORAKOPOULOU M P, DIPLA K, ZAFEIRIDIS A, et al. ndothelial and microvascular function in CKD: evaluation methods and associations with outcomes[J]. Eur J Clin Invest, 2021, 51(8): e13557.

    [29] [29] SPEER T, DIMMELER S, SCHUNK S J, et al. Targeting innate immunity-driven inflammation in CKD and cardiovascular disease[J]. Nat Rev Nephrol, 2022, 18(12): 762-778.

    [30] [30] KOH E S, KIM M, KIM M K, et al. Intra-individual variability in high density lipoprotein cholesterol and risk of end-stage renal disease: a nationwide population-based study[J]. Atherosclerosis, 2019, 286: 135-141.

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    ZHAO Yajun, LIU Ming, DAI Yuxiang, LI Xiaopan, CHENG Xuelin, WANG Qizhe, LIU Ru, XU Yaxin, JIANG Sunfang. The correlation between abnormal metabolic indexes and the severity of coronary artery lesions in patients with acute coronary syndrome[J]. Chinese Journal Of Clinical Medicine, 2025, 32(3): 441

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    Paper Information

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    Received: Mar. 24, 2025

    Accepted: Aug. 22, 2025

    Published Online: Aug. 22, 2025

    The Author Email: JIANG Sunfang (jiang.sunfang@zs-hospital.sh.cn)

    DOI:10.12025/j.issn.1008-6358.2025.20250342

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