1. Characterization of MBGC-xNd microspheres(a-e) TEM images of (a) MBN, (b) MBGC-0Nd microspheres, (c) MBGC-1Nd microspheres, (d) MBGC-3Nd microspheres, and (e) MBGC-5Nd microspheres; (f) High-resolution TEM image of MBGC-3Nd microspheres with insert showing the interplanar crystal spacing at about 0.334 nm; (g) XRD patterns of MBN and MBGC-xNd microspheres; (h) N₂ adsorption-desorption isotherm and (i) pore size distribution curve of MBGC-xNd microsphere The color figures can be obtained from online edition

Scheme 1. Schematic diagram of preparation and properties of MBGC-xNd microspheres and MBGC-xNd/SA bone cementThe color figure can be obtained from online edition

2. Changes of (A) Ca and (B) Si concentrations with MBGC-xNd microspheres in SBFThe color figures can be obtained from online edition

3. Cumulative release curves of DOX from (A) MBGC-xNd@DOX microspheres in PBS at pH 4.7 and (B) MBGC-3Nd/SA@DOX in PBS at pH 4.7 under different ambient temperaturesThe color figures can be obtained from online edition

4. Photothermal properties of MBGC-xNd microspheres(A) Heating curves of MBGC-xNd microspheres under 808 nm laser irradiation (3.2 W/cm²); (B) Heating curves of MBGC-3Nd microspheres under 808 nm laser irradiation at different power densities; (C) Heating curves of MBGC-3Nd/SA immersed in SBF under 808 nm laser irradiation (2.4 W/cm²); (D) Energy level diagram of Nd³⁺The color figures can be obtained from online edition

5. Characterization of MBGC-3Nd/SA bone cement(A) Photo of extruded bone cement; (B) SEM image of MBGC-3Nd/SA; (C) Schematic illustration of the setting process of MBGC-3Nd/SAThe color figures can be obtained from online edition

6. Setting properties of MBGC-xNd/SA(A) Setting time; (B) Injectability; (C) Compressive strength; (D) Anti-washout property. *: p<0.05 (n=5)The color figures can be obtained from online edition

7. (A) Proliferation results and (B) alkaline phosphate activity of rBMSCs cultured in the bone cement extract*: p < 0.05; **: p < 0.01. (n = 5).The color figure can be obtained from online edition

8. Relative survival of MG-63 cells co-cultured with (A) bone cement under 808 nm laser irradiation at a power density of 2.4 W/cm² for 5 min and (B) MBGC-3Nd/SA under PTT, CHT or combination therapy.*: p<0.05; **: p<0.01, ***: p<0.001 (n=5)The color figures can be obtained from online edition