[1] [1] ROMO M, PEREZ MARTINEZ D, FERRER C. Innate immunity in vertebrates:an overview［J］. Immunology, 2016, 148(2): 125-139.

[2] [2] ROBERTSEN B. The interferon system of teleost fish［J］. Fish and Shellfish Immunology, 2010, 20(2): 172-191.

[3] [3] ROMBOUT J H, HUTTENHUIS H B, PICCHIETTI S, et al. Phylogeny and ontogeny of fish leucocytes［J］. Fish and Shellfish Immunol, 2005, 19(5): 441-455.

[4] [4] CARTY M, BOWIE A G. Recent insights into the role of toll-like receptors in viral infection［J］. Clinical and Experimental Immunology, 2010, 161(3): 397-406.

[5] [5] SCHENTEN D, MEDZHITOV R. The control of adaptive immune responses by the innate immune system［J］. Advance in Immunology, 2011, 109(109): 87-124.

[6] [6] ZOU P F, CHANG M X, LI Y, et al. NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-κB, and also MDA5, RIG-I and MAVS［J］. Fish and Shellfish Immunology, 2016, 55: 173-185.

[7] [7] COLLET B, SECOMBES C J. Type I-interferon signalling in fish［J］. Fish and Shellfish Immunology, 2002, 12(5): 389-397.

[8] [8] HIROSE T, FUJINOTO W, TAMAAI T, et al. TAK1:molecular cloning and characterization of a new memberof the nuclear receptor Superfamily［J］. Molecular Endocrinology, 1994, 8(12): 1667-1680.

[9] [9] YAMAGUCHI K, SHIRAKABE K, SHIBUYA H, et al. Identification of a member of the MAPKKK family as a potential mediator of TGF-βsignal transduction［J］. Science, 1995, 270(5244): 2008-2011.

[10] [10] OUYANG C, NIE L, GU M, et al. TGF-β-activated kinase 1(TAK1) activation requires phosphorylation of serine 412 by protein kinase a catalytic subunit α(PKACα) and protein kinase X(PRKX)［J］. Journal of Biological Chemistry, 2014, 289(35): 24226-24237.

[11] [11] CHEN I T, HSU P H, HSU W C, et al. Polyubiquitination of transforming growth factor β-activated kinase 1(TAK1) at lysine 562 residue regulates TLR4-mediated JNK and p38 MAPK activation［J］. Scientific Reports, 2015, 5: 12300.

[12] [12] JADRICH J L, O’CONNOR M B, COUCOUVANIS E. The TGF-β activated kinase TAK1 regulates vascular development in vivo［J］. Development, 2006, 133(8): 1529-1541.

[13] [13] DELANEY J R, MLODZIK M. TGFβ activated Kinase-1: new insights into the diverse roles of TAK1 in development and immunity［J］. Cell Cycle, 2006, 5(24): 2852-2855.

[14] [14] SHIM J H, XIAO C, PASCHL A E, et al. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo［J］.Genes and Development, 2005, 19(22): 2668-2681.

[15] [15] DERYNCK R, ZHANG Y E. TGF-beta-induced signalling pathways［J］.Nature, 2003, 425: 581-583.

[16] [16] PAQUETTE N, CONLON J, SWEET C, et al. Serine/threonine acetylation of TGFβ-activated kinase(TAK1) by Yersinia pestis YopJ in-hibits innate immune signaling［J］.Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(31): 12710-12715.

[17] [17] HIROAKI S, TAKAHISA S, FRANCOIS G, et al. Alternative splicing and gene structure of the transforming growth factor L-activated kinase 1［J］. Biochimica et Biophysica Acta, 2000, 1517(1): 46-52.

[18] [18] ZHAO F, LI Y W, PAN H J, et al. Grass carp(Ctenopharyngodon idella) TRAF6 and TAK1:molecular cloning and expression analysis after Ichthyophthirius multifiliis infection［J］.Fish and Shellfish Immunology, 2013, 34(6): 1514-1523.

[19] [19] LI Y W, LI X, WANG Z, et al. Orange-spotted grouper Epinephelus coioides Tak1:molecular identification, expression analysis and functional study［J］.Journal of Fish Biology, 2015, 86(2): 417-430.

[20] [20] BAO S Y, SUN Q X, YAO C L. The interaction of TAK1 and TAB1 enhances LPS-induced cytokine release via modulating NF-κB activation(Larimichthys crocea)［J］.Fish and Shellfish Immunology, 2018, 74: 450-458.

[21] [21] WANG C, PENG J, FENG H, et al. TAK1 of black carp positively regulates IRF7-mediated antiviral signaling in innate immune activation［J］. Fish and Shellfish Immunology, 2019, 84: 83-90.

[22] [22] ZHOU W, ZHOU J, LV Y, et al. Identification and characterization of MAVS from black carp Mylopharyngodon piceus［J］. Fish and Shellfish Immunology, 2015, 43(2): 460-468.

[23] [23] XIAO J, YAN C, ZHOU W, et al. CARD and TM of MAVS of black carp play the key role in its self-association and antiviral ability［J］.Fish and Shellfish Immunology, 2017, 63: 261-269.

[24] [24] YAN C, XIAO J, LI J, et al. TBK1 of black carp plays an important role in host innate immune response against SVCV and GCRV［J］.Fish and Shellfish Immunology, 2017, 69: 108-118.

[25] [25] TAKEUCHI O, AKIRA S. Pattern recognition receptors and inflammation［J］. Cell, 2010, 140(6): 805-820.

[26] [26] PLOUFFE D A, HANINGTON P C, WALSH J G, et al. Comparison of select innate immune mechanisms of fish and mammals［J］. Xenotransplantation, 2005, 12(4): 266-277.

[27] [27] STEIN C, CACCAMO M, LAIRD G, et al. Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish［J］. Genome Biology, 2007, 8(11): R251.

[28] [28] NOVOA B, FIGUERAS A. Zebrafish:model for the study of inflammation and the innate immune response to infectious diseases［J］.Advances in Experimental Medicine and Biology, 2012, 946: 253-275.

[29] [29] DELANEY C, MLODZIK M. TGFβ activated Kinase-1:new insights into the diverse roles of TAK1 in development and immunity［J］. Cell Cycle, 2006, 5(24): 2852-2855.

[30] [30] KAWAI T, AKIRA S. The role of pattern-recognition receptors in innate immunity:update on Toll-like receptors［J］.Nature Immunology, 2010, 11(5): 373-384.

[31] [31] KAWASKI T, KAWAI T. Toll-like receptor signaling pathways［J］. Frontiers in Immunology, 2014, 5: 461.

[32] [32] LANDSTROM M. The TAK1-TRAF6 signalling pathway［J］. The International Journal of Biochemistry and Cell Biology, 2010, 42(5): 585-589.

[33] [33] KIM S I, WAK J H, NA J H, et al. Transforming growth factor-β(TGF-β1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-β receptor kinase activity in mesangial cells［J］.Journal of Biological Chemistry, 2009, 284(33): 22285-22296.

[34] [34] TAKAESU G, KISHIDA S, HIYAMA A, et al. TAB2:a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway［J］. Molecular Cell, 2000, 5(4): 649-658.

[35] [35] WANG C, DENG L, HONG M, et al. TAK1 is a ubiquitin- dependent kinase of MKK and IKK［J］. Nature, 2001, 412(6844): 346-351.

[36] [36] CAO Z, HENZEL W J, GAO X. IRAK:a kinase associated with the Interleukin-1 receptor［J］. Science, 1996, 271(5252): 1128-1131.

[37] [37] O’NEILL L A, BOWIE A G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signaling［J］. Nature Reviews Immunology, 2007, 7(5): 353-364.

[38] [38] TAKEUCHI O, AKIRA S. Innate immunity to virus infection［J］. Exercise Immunology Review, 2010, 227(1): 75-86.

[39] [39] BARTON G M, KAGAN J C. A cell biological view of Toll-like receptor function:regulation through compartmentalization［J］.Nature Reviews Immunology, 2009, 9(8): 535-542.

[40] [40] SINGHIRUNNUSIN P, SUZUKI S, KAWASAKI N, et al. Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1(TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2［J］.Journal of Biological Chemistry, 2009, 280(8): 7359-7368.

[41] [41] SCHOLZ R, SIDLER C L, THALI R F, et al. Autoactivation of transforming growth factor β-activated kinase 1 is a sequential bimolecular process［J］.Journal of Biological Chemistry, 2010, 285(33): 25753.