Acta Optica Sinica, Volume. 44, Issue 9, 0917001(2024)

Hollow-Core Optical Fiber Optofluidic DNA Sensor Based on Whispering Gallery Mode

Hongxin Zhang, Xuegang Li**, Xue Zhou, Yanan Zhang, and Yong Zhao*
Author Affiliations
  • College of Information Science and Engineering, Northeastern University, Shenyang 110819, Liaoning, China
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    Figures & Tables(11)
    Schematic diagram of packaged sensor
    Electric field distributions under different tapered fiber diameters. (a) 2.4 μm; (b) 1.6 μm; (c) 1.2 μm
    Electric field distributions of resonator under different wall thicknesses. (a) Thickness is 10 μm; (b) thickness is 6.5 μm; (c) thickness is 2.5 μm; (d) thickness is 2 μm
    Electric field distributions under different coupling distances. (a) Coupling distance is 2 μm; (b) coupling distance is 1 μm; (c) coupling distance is 0.6 μm
    Schematic diagram of experimental device
    Refractive index spectra and sensitivity fitting curve of WGM with 4.5 μm thickness tube. (a) Refractive index spectra; (b) sensitivity fitting curve
    Refractive index spectra and sensitivity fitting curve of WGM with 2 μm thickness tube. (a) Refractive index spectra; (b) sensitivity fitting curve
    Functionalization method of WGM optofluidic resonator
    DNA concentration gradient detection experiment of the proposed sensor. (a) WGM spectra under different concentration gradients; (b) localized spectra monitored by sensing; (c) wavelength shift diagram at different concentrations
    Sensing performance experiments of the proposed sensor. (a) Specificity experiment of sensor; (b) spectral shift diagram under different steps; (c) stability experiment of sensor
    • Table 1. Comparison of performance of DNA molecule sensors using WGM

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      Table 1. Comparison of performance of DNA molecule sensors using WGM

      StructureRange /(nmol/L)Sensitivity /(nm/RIU)OptofluidicReference
      Microsphere2013.60NoRef.[21
      Microring0.5-50037.10YesRef.[22
      Double-arc microcapillary0.1-105.36NoRef.[23
      Microtubule10-100206.00YesOur work
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    Hongxin Zhang, Xuegang Li, Xue Zhou, Yanan Zhang, Yong Zhao. Hollow-Core Optical Fiber Optofluidic DNA Sensor Based on Whispering Gallery Mode[J]. Acta Optica Sinica, 2024, 44(9): 0917001

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    Paper Information

    Category: Medical optics and biotechnology

    Received: Dec. 11, 2023

    Accepted: Feb. 20, 2024

    Published Online: May. 15, 2024

    The Author Email: Xuegang Li (lixuegang@ise.neu.edu.cn), Yong Zhao (zhaoyong@ise.neu.edu.cn)

    DOI:10.3788/AOS231916

    CSTR:32393.14.AOS231916

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