Chinese Journal of Pharmaceuticals, Volume. 56, Issue 7, 863(2025)

Optimized Synthetic Process of Mivacurium Chloride

GUO Shuqian1, ZHU Shiguo2, SUN Xiaolei2, ZHANG Naihua2, and ZHANG Guimin1,2、*
Author Affiliations
  • 1School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355
  • 2National Engineering and Technology Research Center of Chirality Pharmaceutical, Lunan Pharmaceutical Group Co., Ltd., Linyi 273400
  • show less
    References(5)

    [5] [5] Savarese J J, YEOWELL D A, SWARINGEN R A,et al. Novel compounds: US, 4761418A [P]. 1988-08-02.

    [8] [8] VELATI M F, BUSCA A, MANFROTTO C,et al. Process for the preparation of mivacurium chloride: US, 0293534A1[P]. 2007-12-20.

    [10] [10] BROWN A R, JAMES C D, WELCH R M,et al. Stereoselective high-performance liquid chromatographic assay with fluorometric detection for the isomers of mivacurium in human plasma [J].J Chromatogr B: Biomed Sci Appl, 1992,578(2): 302-308.

    [11] [11] DAS G K, ARULMOLI T, SEQUENT S L,et al. A process for preparation of mivacurium chloride: WO, 2013021398A2[P]. 2013-02-14.

    [15] [15] VILHANOV B, MATOUEK V, VCLAVK J,et al. Two optimized synthetic pathways toward a chiral precursor of mivacurium chloride and other skeletal muscle relaxants [J].Tetrahedron: Asymmetry, 2013,24(1): 50-55.

    Tools

    Get Citation

    Copy Citation Text

    GUO Shuqian, ZHU Shiguo, SUN Xiaolei, ZHANG Naihua, ZHANG Guimin. Optimized Synthetic Process of Mivacurium Chloride[J]. Chinese Journal of Pharmaceuticals, 2025, 56(7): 863

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Category:

    Received: Dec. 31, 2024

    Accepted: Aug. 26, 2025

    Published Online: Aug. 26, 2025

    The Author Email: ZHANG Guimin (lunanzhangguimin@163.com)

    DOI:10.16522/j.cnki.cjph.2025.07.004

    Topics