[1] [1] Hunter DJ, Bierma-Zeinstra S. Osteoarthritis[J]. Lancet, 2019, 393(10182): 1745-1759.

[2] [2] Andia I, Maffulli N. Platelet-rich plasma for managing pain and inflammation in osteoarthritis[J]. Nat Rev Rheumatol, 2013, 9(12): 721-730.

[3] [3] Di Martino A, Di Matteo B, Papio T, et al. Platelet-rich plasma versus hyaluronic acid injections for the treatment of knee osteoarthritis: results at 5 years of a double-blind, randomized controlled trial[J]. Am J Sports Med, 2019, 47(2): 347-354.

[4] [4] Laver L, Marom N, Dnyanesh L, et al. PRP for degenerative cartilage disease: a systematic review of clinical studies[J]. Cartilage, 2017, 8(4): 341-364.

[5] [5] Kuttapitiya A, Assi L, Laing K, et al. Microarray analysis of bone marrow lesions in osteoarthritis demonstrates upregulation of genes implicated in osteochondral turnover, neurogenesis and inflammation[J]. Ann Rheum Dis, 2017, 76(10): 1764-1773.

[6] [6] Chattrathikul V, Pinthonglor P, Supanchart C, et al. A comparative study of three liquid platelet concentrates on human primary osteoblast activity: an in vitro study[J]. J Appl Oral Sci, 2025, 33: e20240575.

[7] [7] Xie X, Zhang C, Tuan RS. Biology of platelet-rich plasma and its clinical application in cartilage repair[J]. Arthritis Res Ther, 2014, 16(1): 204.

[8] [8] Szwedowski D, Szczepanek J, Paczesny , et al. The effect of platelet-rich plasma on the intra-articular microenvironment in knee osteoarthritis[J]. Int J Mol Sci, 2021, 22(11): 5492.

[9] [9] Snchez M, Fiz N, Guadilla J, et al. Intraosseous infiltration of platelet-rich plasma for severe knee osteoarthritis[J]. Arthrosc Tech, 2014, 3(6): e713-717.

[10] [10] Huang X, Zhao Z, Zhan W, et al. miR-21-5p enriched exosomes from human embryonic stem cells promote osteogenesis via YAP1 modulation[J]. Int J Nanomedicine, 2024, 19: 13095-13112.

[11] [11] Jiang G, Li S, Yu K, et al. A 3D-printed PRP-GelMA hydrogel promotes osteochondral regeneration through M2 macrophage polarization in a rabbit model[J]. Acta Biomater, 2021, 128: 150-162.

[12] [12] Vinod E, Amirtham SM, Kachroo U, et al. Articular chondroprogenitors in platelet rich plasma for treatment of osteoarthritis and osteochondral defects in a rabbit knee model[J]. Knee, 2021, 30: 51-62.

[13] [13] Li M, Zhang FJ, Bai RJ. The hippo-YAP signaling pathway in osteoarthritis and rheumatoid arthritis[J]. J Inflamm Res, 2024, 17: 1105-1120.

[14] [14] Patel S, Rajnish RK, Baburaj V, et al. Intraosseous infiltration of platelet-rich plasma for knee osteoarthritis: a systematic review of literature and limited meta-analysis[J]. Indian J Orthop, 2022, 56(11): 1847-1857.

[15] [15] Nie LY, Zhao K, Ruan J, et al. Effectiveness of platelet-rich plasma in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled clinical trials[J]. Orthop J Sports Med, 2021, 9(3): 2325967120973284.

[17] [17] Annaniemi JA, Pere J, Giordano S. The efficacy of platelet-rich plasma injection therapy in obese versus non-obese patients with knee osteoarthritis: a comparative study[J]. J Clin Med, 2024, 13(9): 2590.

[18] [18] Anitua E, Prado R, Snchez M, et al. Platelet-rich plasma: preparation and formulation[J]. Oper Tech Orthop, 2012, 22(1): 25-32.

[19] [19] Iseki T, Rothrauff BB, Kihara S, et al. Enhanced osteochondral repair by leukocyte-depleted platelet-rich plasma in combination with adipose-derived mesenchymal stromal cells encapsulated in a three-dimensional photocrosslinked injectable hydrogel in a rabbit model[J]. Stem Cell Res Ther, 2024, 15(1): 159.

[20] [20] LaPrade RF, Dragoo JL, Koh JL, et al. AAOS research symposium updates and consensus: biologic treatment of orthopaedic injuries[J]. J Am Acad Orthop Surg, 2016, 24(7): e62-78.

[21] [21] Saqlain N, Mazher N, Fateen T, et al. Comparison of single and double centrifugation methods for preparation of Platelet-Rich Plasma (PRP)[J]. Pak J Med Sci, 2023, 39(3): 634-637.

[23] [23] Sampson S, Gerhardt M, Mandelbaum B. Platelet rich plasma injection grafts for musculoskeletal injuries: a review[J]. Curr Rev Musculoskelet Med, 2008, 1(3/4): 165-174.