[1] [1] Podgorski J, Berg M. Global threat of arsenic in groundwater［J］. Science, 2020, 368(6493): 845-850.

[2] [2] Rahaman M S, Rahman M M, Mise N, et al. Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management［J］. Environmental Pollution, 2021, 289: 117940.

[3] [3] Li S, Zhao H, Wang Y, et al. Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens［J］. Poultry Science, 2019, 98(2): 734-744.

[4] [4] Wang W, Zheng F, Zhang A. Arsenic-induced lung inflammation and fibrosis in a rat model: contribution of the HMGB1/RAGE, PI3K/AKT, and TGF-β1/SMAD pathways［J］. Toxicology and Applied Pharmacology, 2021, 432: 115757.

[5] [5] Amuno S, Rudko D A, Gallino D, et al. Altered neurotransmission and neuroimaging biomarkers of chronic arsenic poisoning in wild muskrats (Ondatra zibethicus) and red squirrels (Tamiasciurus hudsonicus) breeding near the City of Yellowknife, Northwest Territories (Canada)［J］. The Science of the Total Environment, 2020, 707: 135556.

[6] [6] Dani S U, Walter G F. Chronic arsenic intoxication diagnostic score (CAsIDS) ［J］. Journal of Applied Toxicology, 2018, 38(1): 122-144.

[7] [7] Pinto J T, Zempleni J. Riboflavin［J］. Advances in Nutrition, 2016, 7(5): 973-975.

[8] [8] Suwannasom N, Kao I, Pru? A, et al. Riboflavin: the health benefits of a forgotten natural vitamin［J］. International Journal of Molecular Sciences, 2020, 21(3): 950.

[9] [9] Sanches S C, Ramalho L N, Mendes-Braz M, et al. Riboflavin (vitamin B-2) reduces hepatocellular injury following liver ischaemia and reperfusion in mice［J］. Food and Chemical Toxicology, 2014, 67: 65-71.

[10] [10] Li X, Yang J, Liang C, et al. Potential protective effect of riboflavin against pathological changes in the main organs of male mice induced by fluoride exposure［J］. Biological Trace Element Research, 2022, 200(3): 1262-1273.

[11] [11] Jiang X, Yu W, Wu S, et al. Arsenic (III) and/or antimony (III) induced disruption of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in mice heart［J］. Ecotoxicology and Environmental Safety, 2021, 220: 112394.

[12] [12] Ren C, Zhou Y, Liu W, et al. Paradoxical effects of arsenic in the lungs［J］. Environmental Health and Preventive Medicine, 2021, 26(1): 80.

[13] [13] Sharma A, Kshetrimayum C, Sadhu H G, et al. Arsenic-induced oxidative stress, cholinesterase activity in the brain of Swiss albino mice, and its amelioration by antioxidants vitamin E and coenzyme Q10 ［J］.Environmental Science and Pollution Research International, 2018, 25(24): 23946-23953.

[14] [14] Unsal V, Cicek M, Sabancilar ?. Toxicity of carbon tetrachloride, free radicals and role of antioxidants［J］. Reviews on Environmental Health, 2020, 36(2): 279-295.

[15] [15] Powers H J. Riboflavin (vitamin B-2) and health［J］. The American Journal of Clinical Nutrition, 2003, 77(6): 1352-1360.

[16] [16] Mosegaard S, Dipace G, Bross P, et al. Riboflavin deficiency-implications for general human health and inborn errors of metabolism［J］. International Journal of Molecular Sciences, 2020, 21(11): 3847.

[17] [17] Udhayabanu T, Karthi S, Mahesh A, et al. Adaptive regulation of riboflavin transport in heart: effect of dietary riboflavin deficiency in cardiovascular pathogenesis［J］. Molecular and Cellular Biochemistry, 2018, 440(1/2): 147-156.

[18] [18] Wang P, Fan F, Li X, et al. Riboflavin attenuates myocardial injury via LSD1-mediated crosstalk between phospholipid metabolism and histone methylation in mice with experimental myocardial infarction［J］. Journal of Molecular and Cellular Cardiology, 2018, 115: 115-129.

[19] [19] Al-Harbi N O, Imam F, Nadeem A, et al. Riboflavin attenuates lipopolysaccharide induced lung injury in rats［J］. Toxicology Mechanisms and Methods, 2015, 25(5): 417-423.