NUCLEAR TECHNIQUES, Volume. 48, Issue 4, 040301(2025)

Dosimetric effect of respiratory motion on boron neutron capture therapy for lung cancer

Lin ZHU1,2, Tao YU1,2, Aikou SUN1,2, Kekun GAO2, Hongyu QU1,2, Tong LIU4, Song WANG4, Zizhu ZHANG4,5, Yizheng CHONG6, and Zhenping CHEN1,2,3、*
Author Affiliations
  • 1School of Nuclear Science and Technology, University of South China, Hengyang 421001, China
  • 2Key Laboratory of Advanced Nuclear Energy Design and Safety, Ministry of Education, Hengyang 421001, China
  • 3State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China
  • 4Beijing Capture Technology Co. Ltd, Beijing 102413, China
  • 5Beijing Nuclear Industry Hospital, Beijing 102413, China
  • 6China National Nuclear Corporation Overseas Ltd, Beijing 100044, China
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    Figures & Tables(18)
    Schematic diagram of Boron neutron capture therapy principle
    Illustration of multi-function and generalized intelligent code-bench based on Monte Carlo method
    Diagram of the three-dimensional spatial motion trajectory of lung tumors at different respiratory phases under respiratory motion conditions
    Schematic diagram of respiratory motion model
    Sagittal and transverse sections of the adult male phantom
    (a) The energy spectrum distribution of neutron flux density at the exit of the epithermal neutron beam duct; (b) The angular distribution of group neutron current density at the exit of the epithermal neutron beam duct; (c) The energy spectrum distribution of photon flux density at the exit of the epithermal neutron beam duct; (d) The angular distribution of the group photon current density at the exit of the epithermal neutron beam duct
    Contribution and variation with energy of different elements to the neutron energy release ratio in adult lung tissue (color online)
    Dose rate values of dose components for each organ at the reference phase (color online)
    Total relative biological effect dose rate and dose percentage difference of tumor at different phases in various directions under respiratory motion conditions (a) LR, (b) AP, (c) SI
    The statistical errors of dose components for tumors at different phases in various directions under respiratory motion conditions
    Total relative biological effect dose rate and dose percentage difference of healthy tissues at different phases in various directions under respiratory motion conditions (color online) (a) Right lung, (b) Left lung, (c) Heart, (d) Liver, (e) Kidney, (f) Thyroid, (g) Skin
    Statistical error of dose components for healthy tissue organs at different phases in various directions under respiratory motion conditions (color online) (a) LR, (b) AP, (c) SI
    Dose field maps of the chest at the reference phase and the 50% phase (color online) (a) The 20% phase in the LR direction, (b) The 50% phase in the LR direction, (c) The 20% phase in the AP direction, (d) The 50% phase in the AP direction, (e) The 20% phase in the SI direction, (f) The 50% phase in the SI direction
    Total relative biological effect dose rate of tumor and healthy tissues during one cycle under respiratory motion condition (color online) (a) LR, (b) AP, (c) SI
    Dose error in three-dimensional directions considering and not considering respiratory motion conditions (color online)
    • Table 1. RBE and CBE factors of different dose components in tumor and healthy tissues

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      Table 1. RBE and CBE factors of different dose components in tumor and healthy tissues

      BNCT剂量组分 BNCT dose components肿瘤 Tumor健康组织 Healthy tissues皮肤 Skin
      10B(n,α)7Li3.8 (CBE)1.4 (CBE)2.5 (CBE)
      14N(n,p)14C3.23.23.2
      超热中子及快中子 Epithermal and fast neutron3.23.23.2
      光子 Photon1.01.01.0
    • Table 2. Total relative biological effective dose rate of tissues at static reference phase (Gy·min-1)

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      Table 2. Total relative biological effective dose rate of tissues at static reference phase (Gy·min-1)

      组织器官

      Tissues

      总相对生物效应剂量率

      Total relative biological effect dose rate

      肿瘤 Tumor0.319 3
      左肺 Left lung0.002 2
      右肺 Right lung0.024 9
      心脏 Heart0.006 1
      肝脏 Liver0.001 5
      肾脏 Kidney0.000 6
      甲状腺 Thyroid0.003 5
      皮肤 Skin0.003 4
    • Table 3. Total relative biological effect dose (Gy) and total relative biological effect dose difference (%) of tissues during not considering and considering respiratory motion conditions

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      Table 3. Total relative biological effect dose (Gy) and total relative biological effect dose difference (%) of tissues during not considering and considering respiratory motion conditions

      组织器官

      Tissues

      总相对生物效应剂量

      Total relative biological effect dose

      / Gy

      总相对生物效应剂量差异

      Total relative biological effect dose

      difference / %

      不考虑呼吸运动

      Not considering

      respiratory motion

      LRAPSILRAPSI
      肿瘤 Tumor5050.0150.8249.610.0251.644-0.772
      左肺 Left lung0.348 70.348 70.349 30.348 0-0.0130.163-0.200
      右肺 Right lung3.907 03.9103.9533.7720.0661.182-3.458
      心脏 Heart0.954 70.971 10.977 10.968 21.7182.3461.411
      肝脏 Liver0.234 40.234 30.235 80.236 9-0.0400.5811.049
      肾脏 Kidney0.088 30.088 70.089 00.089 30.4430.8461.103
      甲状腺 Thyroid0.542 90.542 70.542 80.542 60.036-0.026-0.046
      皮肤 Skin0.528 50.528 50.528 50.528 40.0090.007-0.023
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    Lin ZHU, Tao YU, Aikou SUN, Kekun GAO, Hongyu QU, Tong LIU, Song WANG, Zizhu ZHANG, Yizheng CHONG, Zhenping CHEN. Dosimetric effect of respiratory motion on boron neutron capture therapy for lung cancer[J]. NUCLEAR TECHNIQUES, 2025, 48(4): 040301

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    Paper Information

    Category: NUCLEAR CHEMISTRY, RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

    Received: Jul. 2, 2024

    Accepted: --

    Published Online: Jun. 3, 2025

    The Author Email: Zhenping CHEN (陈珍平)

    DOI:10.11889/j.0253-3219.2025.hjs.48.240273

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