[1] [1] WANG Y Q. The role of T cells in the development of Henoch-Sch?nlein purpura［J］. Frontiers in Bioscience, 2018, 23(3): 837-851.

[2] [2] PIRAM M, MALDINI C, BISCARDI S, et al. Incidence of IgA vasculitis in children estimated by four-source capture-recapture analysis: a population-based study［J］. Rheumatology, 2017, 56(8): 1358-1366.

[3] [3] RUPERTO N, OZEN S, PISTORIO A, et al. EULAR/PRINTO/PRES criteria for Henoch-Sch?nlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: overall methodology and clinical characterisation［J］. Annals of the Rheumatic Diseases, 2010, 69(5): 790-797.

[4] [4] GARDNER-MEDWIN J M, DOLEZALOVA P, CUMMINS C, et al. Incidence of Henoch-Sch?nlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins［J］. The Lancet, 2002, 360(9341): 1197-1202.

[6] [6] TAKAHASHI K, OHARASEKI T, YOKOUCHI Y, et al. Overview of the 2012 revised international chapel hill consensus conference nomenclature of vasculitides (CHCC2012)［J］. Nihon Jinzo Gakkai Shi, 2014, 56(2): 70-79.

[7] [7] STEWART M, SAVAGE J M, BELL B, et al. Long term renal prognosis of Henoch-Sch?nlein purpura in an unselected childhood population［J］. European Journal of Pediatrics, 1988, 147(2): 113-115.

[8] [8] RONKAINEN J, NUUTINEN M, KOSKIMIES O. The adult kidney 24 years after childhood Henoch-Sch?nlein purpura: a retrospective cohort study［J］. The Lancet, 2002, 360(9334): 666-670.

[9] [9] AUDEMARD-VERGER A, PILLEBOUT E, GUILLEVIN L, et al. IgA vasculitis (Henoch-Sh?nlein purpura) in adults: diagnostic and therapeutic aspects［J］. Autoimmunity Reviews, 2015, 14(7): 579-585.

[11] [11] LI B, YANG M, HE G, et al. Efficacy and safety of Chinese herbs for the prevention of the risk of renal damage in Henoch-Sch?nlein purpura in children: meta-analysis of randomized controlled trials and GRADE evaluation［J］. Evidence-based Complementary and Alternative Medicine, 2019(2019): 1-16.

[13] [13] INUI M, MARTELLO G, PICCOLO S. MicroRNA control of signal transduction［J］. Nature Reviews Molecular Cell Biology, 2010, 11(4): 252-263.

[14] [14] MOHR A M, MOTT J L. Overview of microRNA biology［J］. Seminars in Liver Disease, 2015, 35(1): 3-11.

[15] [15] OUZOUNIS C A, VALENCIA A. Early bioinformatics: the birth of a discipline－a personal view［J］. Bioinformatics (Oxford, England), 2003, 19(17): 2176-2190.

[17] [17] BARRETT T, STEPHEN E W, PIERRE L, et al. NCBI GEO: archive for functional genomics data sets—update［J］. Nucleic Acids Research, 2013, 41(D1): D991-D995.

[18] [18] STELZER G, NAOMI R, INBAR P, et al. The GeneCards suite: from gene data mining to disease genome sequence analyses［J］. Current Protocols in Bioinformatics, 2016, 54(1): 1-30.

[19] [19] ZHENG S, JAN P B, SHUANG L, et al. Network pharmacology analysis of the therapeutic mechanisms of the traditional Chinese herbal formula Lian Hua Qing Wen in corona virus disease 2019 (COVID-19), gives fundamental support to the clinical use of LHQW［J］. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 2020, 79: 153336.

[20] [20] ZHOU Y, BIN Z, PACHE L, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets［J］. Nature Communications, 2019, 10(1): 1523.

[21] [21] GORJI-BAHRI G, MOGHIMI H R, HASHEMI A. RAB5A is associated with genes involved in exosome secretion: integration of bioinformatics analysis and experimental validation［J］. Journal of Cellular Biochemistry, 2021, 122(3/4): 425-441.

[22] [22] RU J, PENG L, JINAN W. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines［J］. Journal of Cheminformatics, 2014, 6(1): 13.

[24] [24] ILIOPOULOS D, A H H, STRUHL K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation［J］. Cell, 2009, 139(4): 693-706.

[25] [25] LIU J, ZHU L, XIE G, et al. Let-7 miRNAs modulate the activation of NF-κB by targeting TNFAIP3 and are involved in the pathogenesis of lupus nephritis［J］. PLoS One, 2015, 10(6): e121256.

[26] [26] SERINO G, FRANCESCO P, FABIO S, et al. In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy［J］. Kidney International, 2016, 89(3): 683-692.

[31] [31] BLACK R, CHARLES T R, CARL J K. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells［J］. Nature, 1997, 385(6618): 729-733.

[32] [32] MOSS M, JIN S L, MILLA M. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha［J］. Nature, 1997, 385(6618): 733-736.

[33] [33] PESCHON J, JENNIFER-L S, PRANITHA R. An essential role for ectodomain shedding in mammalian development［J］. Science (New York, N Y), 1998, 282(5392): 1281-1284.

[34] [34] REDDY P, JENNIFER L S, RAYMOND D. Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme［J］. The Journal of Biological Chemistry, 2000, 275(19): 14608-14614.

[35] [35] MARINO M W, DUNN A, GRAIL D, et al. Characterization of tumor necrosis factor-deficient mice［J］. Proceedings of the National Academy of Sciences of the United States of America, 1997, 94(15): 8093-8098.

[36] [36] YIN Y, FEI L, JING S, et al. MiR-146a regulates inflammatory infiltration by macrophages in polymyositis/dermatomyositis by targeting TRAF6 and affecting IL-17/ICAM-1 pathway［J］. Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 2016, 40(3/4): 486-498.

[38] [38] MOAAZ M, SARA Y, AMR E, et al. Th17/Treg cells imbalance and their related cytokines (IL-17, IL-10 and TGF-β) in children with autism spectrum disorder［J］. Journal of Neuroimmunology, 2019(337): 577071.

[39] [39] SCHMIDT T, JONAS L, HANS-JOACHIM P, et al. Mechanisms and functions of IL-17 signaling in renal autoimmune diseases［J］. Molecular Immunology, 2018, 104: 90-99.

[41] [41] SHIH R, CHEN Y, YANG C. NF-kappaB signaling pathways in neurological inflammation: a mini review［J］. Frontiers in Molecular Neuroscience, 2015, 8: 77.

[45] [45] LI J, CHEN M, WANG J, et al. MicroRNA profiling in Chinese children with Henoch-Sch?nlein purpura and association between selected microRNAs and inflammatory biomarkers［J］. Acta Paediatrica (Oslo, Norway: 1992), 2021, 110(7): 2221-2229.