Chinese Journal of Lasers, Volume. 46, Issue 9, 907002(2019)

Multichannel Diffuse Correlation Spectroscopy Topography System

Hui Zifan1, Xie Jinbin1, He Xiangdong1, Qin Zhuanping2, and Gao Feng1,3
Author Affiliations
  • 1College of Precision Instruments and Opto-Electronic Engineering, Tianjin University, Tianjin 300072, China
  • 2School of Automation and Electrical Engineering, Tianjin University of Technology and Education,Tianjin 300222, China
  • 3Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China
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    Figures & Tables(9)
    Schematic of diffusion correlation spectroscopy
    Diffuse correlation topography system. (a) Schematic of system; (b) source-detector distribution
    Diagram of multi-tau photon correlator
    Structural diagrams of dynamic phantom. (a) Three-dimensional structure of dynamic phantom connected to peristaltic pump to change flow rate(purple represents solid part, light blue represents liquid background, and dark blue represents target area); (b) transverse section of dynamic phantom (blue represents source, orange represents detector, and red represents imaging area)
    Linearity assessment of system
    Experimental results at four different flow rates. (a) Normalized intensity temporal autocorrelation curves;(b) linear graph of fitted blow flow index
    Topological imaging results of single flow rate channel. (a) Correlation curves at flow rate of 0 mm·s-1; (b) topological image at flow rate of 0 mm·s-1; (c) correlation curves at flow rate of 0.76 mm·s-1; (d) topological image at flow rate of 0.76 mm·s-1; (e) correlation curves at flow rate of 1.52 mm·s-1; (f) topological image at flow rate of 1.52 mm·s-1
    Topological imaging results of two channels with different flow rates. (a) Normalized intensity temporal autocorrelation curves in experiment; (b) topological image
    • Table 1. Fitting results of four different flow rates

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      Table 1. Fitting results of four different flow rates

      Speed of pump Vpump /(r·min-1)0204060
      Volumetric flow rate Q /(mL·s-1)00.140.280.42
      Liquid flow rate V /(mm·s-1)00.761.522.28
      Number of iterations14131313
      Value of objective function0.04210.05580.07240.0820
      BFI /(cm2·s-1)8.7073×10-81.4856×10-72.6482×10-74.7670×10-7
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    Hui Zifan, Xie Jinbin, He Xiangdong, Qin Zhuanping, Gao Feng. Multichannel Diffuse Correlation Spectroscopy Topography System[J]. Chinese Journal of Lasers, 2019, 46(9): 907002

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Apr. 11, 2019

    Accepted: --

    Published Online: Sep. 10, 2019

    The Author Email:

    DOI:10.3788/CJL201946.0907002

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