Chinese Journal of Lasers, Volume. 46, Issue 9, 907002(2019)

Multichannel Diffuse Correlation Spectroscopy Topography System

Hui Zifan1, Xie Jinbin1, He Xiangdong1, Qin Zhuanping2, and Gao Feng1,3
Author Affiliations
  • 1College of Precision Instruments and Opto-Electronic Engineering, Tianjin University, Tianjin 300072, China
  • 2School of Automation and Electrical Engineering, Tianjin University of Technology and Education,Tianjin 300222, China
  • 3Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China
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    Diffuse correlation spectroscopy (DCS) is a rapidly growing optical technology to noninvasively assess the tissue blood flow index. We develop a multichannel DCS topography system based on a multi-tau photon correlator, which comprises a long coherence length laser, a photomultiplier tube, and a photon correlator. The multi-tau photon correlator structure can obtain the intensity temporal correlation curve with high resolution and large dynamic range. Combining the imaging characteristics of the system, the constrained nonlinear optimization algorithm based on the analytical solution of the correlation diffusion equation is used as the model. The model is applied to match data between actual measurements and model predictions calculated by analytically solving the correlation diffusion equation in semi-infinite geometry. Finally, the dynamic phantom experiments demonstrate that the imaging system can distinguish different flow rates of liquid medium to reconstruct a two-dimensional image of flow rate distribution.

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    Hui Zifan, Xie Jinbin, He Xiangdong, Qin Zhuanping, Gao Feng. Multichannel Diffuse Correlation Spectroscopy Topography System[J]. Chinese Journal of Lasers, 2019, 46(9): 907002

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Apr. 11, 2019

    Accepted: --

    Published Online: Sep. 10, 2019

    The Author Email:

    DOI:10.3788/CJL201946.0907002

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