Advances in Optical Imaging for Monitoring Photodynamic Therapy Dosimetry

Li Wenbo; Shen Yi; Li Buhong

doi:10.3788/CJL202047.0207006

Chinese Journal of Lasers, Volume. 47, Issue 2, 207006(2020)

Advances in Optical Imaging for Monitoring Photodynamic Therapy Dosimetry

Li Wenbo, Shen Yi, and Li Buhong

Key Laboratory of Opto-Electronic Science and Technology for Medicine of Ministry of Education,Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou, Fujian 350007, China

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Figures & Tables(6)

Fig. 1. PDT principle and the optical monitoring for dose parameters

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Fig. 2. Applications of optical imaging techniques in monitoring PDT dose

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Table 1. Optical imaging techniques for quantifying photosensitizer concentration

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Table 1. Optical imaging techniques for quantifying photosensitizer concentration

Optical imagingtechnique	Parameter	Quantitative algorithm	Measured data	Sensitivity	Reference
QFI	Concentration	Spectral constraintnormalization	Absolute value	20 ng/mL	[25]
	Concentration	Spectral constraintnormalization	Absolute value	8 ng/mL	[28]
QSFFI	Concentration	Standard diffusionapproximation	Absolute value	20 ng/g	[31]
WSRFI	Concentration	Improved spectrallyconstrained normalization	Absolute value	10 ng/mL	[30]

Table 2. Optical imaging techniques for monitoring oxygen parameters

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Table 2. Optical imaging techniques for monitoring oxygen parameters

Oxygen parameter	Optical imaging techniques	Measured data	Reference
	Ultrasound-PAI	Relative value	[40]
Oxygen saturation	PAM	Relative value	[41]
	MSOT	Relative value	[42]
	Visible light OCT	Relative/absolute value	[48]
Tissue oxygen partial pressure	PALI	Absolute value (0--13332 Pa)	[46]

Table 3. Optical imaging techniques for ¹O₂ luminescence

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Table 3. Optical imaging techniques for ¹O₂ luminescence

Imaging technique	Detector	Advantages of imaging system	Reference
	PMT (photomultiplier tube)	Large active area (>10 mm×10 mm)	[54]
Time-resolved	SNSPD	Low dark count rates, high detection efficiency (>85%) and detection of wide spectrum	[55]
	NFAD	Achieve DCR as low as 1 countsper second at 10% efficiency	[56]
		Resolution: 50 μm; imaging time: ~1 s	[57]
Spatial-resolved	NIR CCD	Resolution: 46 μm; imaging time: <30 s	[58]
		Resolution: 30 μm; imaging time: ~2 s	[59]

Table 4. Optical imaging techniques for monitoring vascular response

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Table 4. Optical imaging techniques for monitoring vascular response

Optical imaging technique		Parameter	Reference
LDI		Relative blood flow velocity	[60]
LSI		Vascular morphology and relative blood flow velocity	[69]
	DOCT	Relative blood flow velocity (resolution:>18 μm; depth:1 mm)	[81]
Functional OCT	OCTA	Microvasculature (resolution:>5 μm; depth:3 mm)	[82]
	MML-OCA	Flowing/functional microvasculature (resolution:>10 μm; depth:1.3 mm)	[85]
PAI	PAT	Vascular morphology (resolution:0.1--1.0 mm; depth:<10 cm)	[71]
	PAM	Vascular morphology (resolution:>30 μm; depth:superficial vasculature)	[41]

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Li Wenbo, Shen Yi, Li Buhong. Advances in Optical Imaging for Monitoring Photodynamic Therapy Dosimetry[J]. Chinese Journal of Lasers, 2020, 47(2): 207006

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