[1] [1] Miles B N,Ivanov A P,Wilson K A, et al. Single Molecule Sensing with SolidState Nanopores: Novel Materials, Methods, and Applications［J］. Chemical Society Reviews, 2012, 42(1) : 1528.

[2] [2] Dong G,Hou J,Jing W, et al. Enhanced CO2/N2 Separation by Porous Reduced Graphene Oxide/Pebax Mixed Matrix Membranes［J］. Journal of Membrane Science, 2016, 520: 860868.

[3] [3] Park H B,Kamcev J,Robeson L M, et al. Maximizing the Right Stuff: The TradeOff between Membrane Permeability and Selectivity［J］. Science, 2017, 356(6343) : 11381148.

[4] [4] Riedl J,Ding Y,Fleming A M, et al. Identification of DNA Lesions Using a Third Base Pair for Amplification and Nanopore Sequencing［J］. Nature Communications, 2015, 6: 8807.

[5] [5] Xi D,Shang J,Fan E, et al. NanoporeBased Selective Discrimination of Micrornas with SingleNucleotide Difference Using Locked Nucleic AcidModified Probes［J］. Analytical Chemistry, 2016 : 6b02620.

[6] [6] Erik Y,Brandon B,Eggenberger O M, et al. RealTime Shape Approximation and Fingerprinting of Single Proteins Using a Nanopore［J］. Nature nanotechnology, 2017, 12(4) : 360367.

[7] [7] Wang H Y,Song Z Y,Zhang H S, et al. SingleMolecule Analysis of Lead(II)Binding Aptamer Conformational Changes in an ΑHemolysin Nanopore, and Sensitive Detection of Lead(II)［J］. Microchimica Acta, 2016, 183(3) : 10031010.

[8] [8] Goyal G,Freedman K J,Kim M J, et al. Gold Nanoparticle Translocation Dynamics and Electrical Detection of Single Particle Diffusion Using SolidState Nanopores［J］. Analytical Chemistry, 2013, 85(17) : 81808187.

[9] [9] Venta K E,Zanjani M B,Ye X, et al. Gold Nanorod Translocations and Charge Measurement through SolidState Nanopores［J］. Nano Letters, 2014, 14(9):53585364.

[10] [10] Wen C,Zhang S. Fundamentals and Potentials of SolidState Nanopores: A Review［J］. Journal of Physics D: Applied Physics, 2021, 54(2) : 023001.

[11] [11] Shi W,Friedman A K,Baker L A. Nanopore Sensing［J］. Analytical Chemistry, 2017, 89(1) : 157188.

[12] [12] Caglar M,Silkina I,Brown B T, et al. Tunable Anion Selective Transport through MonoLayer Graphene and Hexagonal Boron Nitride［J］. ACS Nano, 2019, 14: 27292738.

[13] [13] Deamer D,Akeson M B,Ranton D J, et al.Three Decades of Nanopore Sequencing［J］. Biophysical Journal, 2016, 34(5) : 518524.

[14] [14] Bafna J A,Soni G V, Meni W J, et al. Fabrication of Low Noise Borosilicate Glass Nanopores for Single Molecule Sensing［J］. Plos One, 2016, 11(6) : e0157399.

[15] [15] Roozbahani G M, Chen X, Zhang Y, et al. PeptideMediated Nanopore Detection of Uranyl Ions in Aqueous Media［J］. ACS Sensors, 2017, 2(5) : 703709.

[16] [16] Luo S,Hoff B H,Maier S A, et al. Scalable Fabrication of Metallic Nanogaps at the Sub10 nm Level［J］. Advanced Science, 2021, 8: 2102756.

[17] [17] Zhan P,Wen T,Wang Z G, et al. DNA Origami Directed Assembly of Gold Bowtie Nanoantennas for SingleMolecule SurfaceEnhanced Raman Scattering［J］. Angewandte ChemieInternational Edition, 2018, 57(11) : 28462850.

[21] [21] Huang L P,Sun H W,Sun L B, et al. Rapid, LabelFree Histopathological Diagnosis of Liver Cancer Based on Raman Spectroscopy and Deep Learning［J］. Nature Communications, 2023, 14: 48.

[22] [22] Spitzberg J D,Zrehen A,Kooten X F, et al. PlasmonicNanopore Biosensors for Superior SingleMolecule Detection［J］. Advanced Materials, 2019, 31(23) : 1900422.

[24] [24] Ge Y C,Yang Y,Zhu Y J, et al. 2D Tis2Nanosheet‐Coated Concave Gold Arrays with Triple‐Coupled Resonances as Sensitive Sers Substrates［J］. Small, 2023, 2302410.

[25] [25] Ge Y C,Wang F,Yang Y, et al. Atomically Thin Tase2 Film as a HighPerformance Substrate for SurfaceEnhanced Raman Scattering［J］. Small, 2022, 2107027.

[26] [26] Huang J A,Mousavi M Z,Giovannini G, et al. Multiplexed Discrimination of Single Amino Acid Residues in Polypeptides in a Single Sers Hot Spot［J］. Angewandte ChemieInternational Edition, 2020, 59(28) : 1142311431.

[27] [27] Huang J A,Mousavi M Z,Zhao Y, et al. Sers Discrimination of Single DNA Bases in Single Oligonucleotides by ElectroPlasmonic Trapping［J］. Nature Communications, 2019, 10(1) : 5321.

[28] [28] Maxim B,Chen S H, Magnus P J, et al. Plasmonic Nanopores for Trapping,Controlling Displacement, and Sequencing of DNA［J］. ACS Nano, 2015, 9: 1059810611.

[29] [29] Matsuda R,Ryuzaki S,Okamoto K, et al. FiniteDifference TimeDomain Simulations of Inverted ConeShaped Plasmonic Nanopore Structures［J］. Journal of Applied Physics, 2020, 127(24) : 243109.

[30] [30] Yang J M,Pan Z Q,Qin F F, et al. An in Situ Sersstudy of Ionic Transport and the Joule Heating Effect in Plasmonic Nanopores［J］. Chemical Communications, 2018, 54(94) : 1323613239.

[31] [31] Clemente F,Kox R,Lagae L, et al. Raman Scattered Photon Transmission through a Single Nanoslit［J］. Applied Physics Letters, 2010, 96(6) : 061108.

[32] [32] Cressiot B,Bacri LPelta J. The Promise of Nanopore Technology: Advances in the Discrimination of Protein Sequences and Chemical Modifications［J］. Small Methods, 2020, 4(11):2000090.

[33] [33] Garoli D,Haung J A,Andrews D L, et al., Ultrahigh Sensitivity Sers Detection of DNA and Protein Translocating through a Plasmonic Nanopores［J］. Nanophotonics, 2022, 10(4) : 2354.

[34] [34] Yang D,Liu G,Li H, et al. The Fabrication of a Gold NanoelectrodeNanopore Nanopipette for Dopamine Enrichment and Multimode Detection［J］. Analyst, 2020, 145(3) : 10471055.

[35] [35] Cecchini M P,Wiener A,Turek V A, et al. Rapid Ultrasensitive Single Particle SurfaceEnhanced Raman Spectroscopy Using Metallic Nanopores［J］. Nano Letters, 2013, 13(10) : 46024609.

[36] [36] Zhou J,Zhou P L,Shen Q, et al. Probing Multidimensional Structural Information of Single Molecules Transporting through a Sub10 nm Conical Plasmonic Nanopore by Sers［J］. Analytical Chemstry, 2021, 93(34) : 1167911685.

[37] [37] Ding S Y,Yi J,Li J F, et al. NanostructureBased PlasmonEnhanced Raman Spectroscopy for Surface Analysis of Materials［J］. Nature Reviews Materials, 2016, 1(6):16021.

[38] [38] Osminkina L A,ukovskaja O,Agafilushkina S N, et al. Gold Nanoflowers Grown in a Porous Si/SiO2 Matrix: The Fabrication Process and Plasmonic Properties［J］. Applied Surface Science,2019: 144989.

[39] [39] Yakimchuk D V,Kaniukov E Y,Lepeshov S I, et al. Spatially Separated SelfAssembled Silver Dendrites for Highly Sensitive Sers Applications［J］. Journal of Electroanalytical Chemistry, 2018, 5(2):868.

[40] [40] Almehmadi L M,Curley S M,Tokranova N A, et al. Surface Enhanced Raman Spectroscopy for Single Molecule Protein Detection［J］. Scientific Repopts, 2019, 9(1) : 12356.

[41] [41] Liang, Xue H Y, Ren R, et al. SolidState Nanopore Sensors［J］. Nature Reviews Materials, 2020, 5: 931951.

[42] [42] Liu H L,Cao J,Hanif S, et al. SizeControllable Gold Nanopores with High Sers Activity［J］. Analytical Chemistry, 2017, 89(19) : 1040710413.

[43] [43] Wang J,Fang R,Hou J, et al. Oscillatory Reaction Induced Periodic CQuadruplex DNA Gating of Artificial Ion Channels［J］. ACS Nano, 2017, 11(3) : 3022.

[44] [44] Yang J M,Jin L,Pan Z Q, et al. SurfaceEnhanced Raman Scattering Probing the Translocation of DNA and Amino Acid through Plasmonic Nanopores［J］. Analytical Chemistry, 2019, 91(9) : 62756280.

[45] [45] Nascimento R A S,Ozel R E,Mak W H, et al. Single Cell "Glucose Nanosensor" Verifies Elevated Glucose Levels in Individual Cancer Cells［J］. Nano Letters, 2016, 2: 11941200.

[46] [46] Wei F,Zhang ,Chen Y, et al. Portable SersEnabled Micropipettes for Microarea Sampling and Reliably Quantitative Detection of Surface Organic Residues［J］. Analytical Chemistry, 2015, 87(18) : 92179224.

[47] [47] Liu H,Jiang Q,Pang J, et al. A Multiparameter PhSensitive Nanodevice Based on Plasmonic Nanopores［J］. Advanced Functional Materials, 2018, 28(1) : 1703847.

[48] [48] Cao J,Liu H L,Yang J M, et al. Sers Detection of Nucleobases in Single Silver Plasmonic Nanopores［J］. ACS Sensors, 2020, 5(7) : 21982204.

[49] [49] Shen Q,Zhou P L,Huang B T, et al. Mass Transport through a Sub10 nm Single Gold Nanopore: Sers and Ionic Current Measurement［J］. Journal of Electroanalytical Chemistry, 2021, 894: 115373.

[50] [50] Freedman K J,Crick C R,Albella P, et al. OnDemand Surface and TipEnhanced Raman Spectroscopy Using Dielectrophoretic Trapping and Nanopore Sensing［J］. ACS Photonics, 2016, 3(6) : 10361044.

[51] [51] Tian S,Neumann O,McClain M J, et al. Aluminum Nanocrystals: A Sustainable Substrate for Quantitative SersBased DNA Detection［J］. Nano Letters, 2017, 17(8) : 50715077.

[52] [52] Xu L J,Lei Z C,Li J, et al. LabelFree SurfaceEnhanced Raman Spectroscopy Detection of DNA with SingleBase Sensitivity［J］. Journal of the American Chemical Society, 2015, 137(15) : 51495154.

[53] [53] Chen C,Li Y,Kerman S, et al. High Spatial Resolution Nanoslit Sers for SingleMolecule Nucleobase Sensing［J］. Nature Communications, 2018, 9(1) : 1733.

[54] [54] Asandei A,Di Muccio G,Schiopu I, et al. Nanopore‐Based Protein Sequencing Using Biopores: Current Achievements and Open Challenges［J］. Small Methods, 2020, 4(11) : 1900595.

[55] [55] Ding T,Chen A K,Lu Z. The Applications of Nanopores in Studies of Proteins［J］. Science Bulletin, 2019, 64(19) : 14561467.

[56] [56] Esteban R,Baumberg J J,Aizpurua J. Molecular Optomechanics Approach to SurfaceEnhanced Raman Scattering［J］. Accounts of Chemical Research, 2022, 55(14) : 18891899.

[57] [57] Lin Y,Ying Y L,Gao R, et al. SingleMolecule Sensing with Nanopore Confinement: From Chemical Reactions to Biological Interactions［J］. Chemistry, 2018, 24(50) : 1306413071.

[58] [58] Nicolai A,Barrios Perez M D,Delarue P, et al. Molecular Dynamics Investigation of Polylysine Peptide Translocation through MoS2 Nanopores［J］. Journal of Physical Chemistry B, 2019, 123(10) : 23422353.

[59] [59] Nie X L,Liu H L,Pan Z Q, et al. Recognition of Plastic Nanoparticles Using a Single Gold Nanopore Fabricated at the Tip of a Glass Nanopipette［J］. Chemical Communications, 2019, 55(45) : 63976400.