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Chinese Journal of Lasers, Volume. 47, Issue 2, 207014(2020)

Progress in Biomedical Imaging Based on Terahertz Quantum Cascade Lasers

Fu Zhanglong1, Li Ruizhi1,2, Li Hongyi1,2, Shao Dixiang1, and Cao Juncheng1、*
Author Affiliations
  • 1Key Laboratory of Terahertz Solid-State Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China
  • 2University of Chinese Academy of Sciences, Beijing 100049, China
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    Figures&Tables (12)
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    References (30)
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    Figures & Tables(12)
    THz QCL. (a) Physical map of THz QCL; (b) operation principle of THz QCL

    Fig. 1. THz QCL. (a) Physical map of THz QCL; (b) operation principle of THz QCL

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    Direct transmission imaging system with THz QCL[17]

    Fig. 2. Direct transmission imaging system with THz QCL[17]

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    Images of rat tissues[17]. (a) Visible images and (b) THz images of liver, fat, muscle, and tendon of rat respective; (c) visible image and (d) THz image of slice of rat brain; (e) visible image and (f) THz image of healthy liver slice of rat; (g) visible image and (h) THz image of the metastasis liver slice of rat

    Fig. 3. Images of rat tissues[17]. (a) Visible images and (b) THz images of liver, fat, muscle, and tendon of rat respective; (c) visible image and (d) THz image of slice of rat brain; (e) visible image and (f) THz image of healthy liver slice of rat; (g) visible image and (h) THz image of the metastasis liver slice of rat

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    Reflection imaging system with THz QCL and its imaging results[19]. (a) Reflection imaging system with THz QCL; (b)(c) visible images of rat brain frontal sections; (d)(e) THz images of rat brain frontal sections

    Fig. 4. Reflection imaging system with THz QCL and its imaging results[19]. (a) Reflection imaging system with THz QCL; (b)(c) visible images of rat brain frontal sections; (d)(e) THz images of rat brain frontal sections

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    Coherent imaging system with THz OCL[20]

    Fig. 5. Coherent imaging system with THz OCL[20]

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    Porcine tissue samples and imaging experiment results[20]. 5 mm thick tissue from porcine abdomen: (a) sample; (b) visible image; (c) amplitude-like image of THz waves; (d) phase-like image of THz waves. 40, 60, 80, 100 μm thick tissues from porcine abdominal skin: (e) samples; (f) visible image; (g) amplitude-like image of THz waves; (h) phase-like image of THz waves

    Fig. 6. Porcine tissue samples and imaging experiment results[20]. 5 mm thick tissue from porcine abdomen: (a) sample; (b) visible image; (c) amplitude-like image of THz waves; (d) phase-like image of THz waves. 40, 60, 80, 100 μm thick tissues from porcine abdominal skin: (e) samples; (f) visible image; (g) amplitude-like image of THz waves; (h) phase-like image of THz waves

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    Differential imaging system with THz QCL and its imaging experiment results[22-23]. (a) Imaging system with 4.9 THz QCL and VOx microbolometer focal plane array (optical path >25 m); (b) visible image of dried seed pod; (c)THz image of dried seed pod

    Fig. 7. Differential imaging system with THz QCL and its imaging experiment results[22-23]. (a) Imaging system with 4.9 THz QCL and VOx microbolometer focal plane array (optical path >25 m); (b) visible image of dried seed pod; (c)THz image of dried seed pod

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    Confocal microscope system with THz QCL and its imaging experiment results[26]. (a) Confocal THz microscope system; (b) visible image of the fresh leaf; (c) confocal THz image of the fresh leaf

    Fig. 8. Confocal microscope system with THz QCL and its imaging experiment results[26]. (a) Confocal THz microscope system; (b) visible image of the fresh leaf; (c) confocal THz image of the fresh leaf

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    Confocal microscope system with THz QCL and its imaging experiment results[27-28]. (a) Confocal THz microscope system; (b) visible image of the fresh leaf; (c) THz image of the fresh leaf; (d) confocal THz fine image of rectangular frame in Fig.9(c)

    Fig. 9. Confocal microscope system with THz QCL and its imaging experiment results[27-28]. (a) Confocal THz microscope system; (b) visible image of the fresh leaf; (c) THz image of the fresh leaf; (d) confocal THz fine image of rectangular frame in Fig.9(c)

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    Digital holography system with THz QCL and its imaging experiment results[29]. (a) THz digital holography system; (b) picture of a 30 μm thick human skin histological slice; (c) reconstructed amplitude image of THz waves; (d) reconstructed phase image of THz waves

    Fig. 10. Digital holography system with THz QCL and its imaging experiment results[29]. (a) THz digital holography system; (b) picture of a 30 μm thick human skin histological slice; (c) reconstructed amplitude image of THz waves; (d) reconstructed phase image of THz waves

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    Multicolor imaging system with THz QCL and its imaging experiment results[30]. (a) Multicolor THz imaging system; (b) sagittal T1 weighted magnetic resonance image of metastatic brain tumor and normal brain tissue; (c) transmission spectra of the normal tissue and brain metastasis; (d) multicolor THz images for the tumor sample

    Fig. 11. Multicolor imaging system with THz QCL and its imaging experiment results[30]. (a) Multicolor THz imaging system; (b) sagittal T1 weighted magnetic resonance image of metastatic brain tumor and normal brain tissue; (c) transmission spectra of the normal tissue and brain metastasis; (d) multicolor THz images for the tumor sample

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    • Table 1. Parameters of biomedical imaging system based on THz QCL

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      Table 1. Parameters of biomedical imaging system based on THz QCL

      Imaging typeQCL emittingfrequency /THzQCLpower /mWDetectionarray sizeResolution /μmSignal tonoise ratio /dB
      Transmission imaging3.741 pixel280(x)/340(y)33
      Reflection imaging3.45201 pixel170(x)/240(y)30
      Self-mixing coherent imaging2.590.29--0.731 pixel//
      Differential imaging4.917320 pixel×240 pixel75010
      Confocal imaging2.52/2.9501 pixel70(lateral)/400(axial)45
      Digital holography2.84640 pixel×480 pixel~200/
      Multicolor imaging2.5/3.4/4.0/4.31--104 pixel×4 pixel~800/
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    Fu Zhanglong, Li Ruizhi, Li Hongyi, Shao Dixiang, Cao Juncheng. Progress in Biomedical Imaging Based on Terahertz Quantum Cascade Lasers[J]. Chinese Journal of Lasers, 2020, 47(2): 207014

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    Paper Information

    Category: biomedical photonics and laser medicine

    Received: Oct. 14, 2019

    Accepted: --

    Published Online: Feb. 21, 2020

    The Author Email: Juncheng Cao (jccao@mail.sim.ac.cn)

    DOI:10.3788/CJL202047.0207014

    Topics

    laser devices and laser physics
    Lasers and Laser Optics
    Laser physics
    laser manufacturing
    Instrumentation, Measurement and Metrology