International Journal of Extreme Manufacturing, Volume. 7, Issue 1, 12009(2025)
Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration
[1] [1] Fodor L and Dumitrascu D 2019 Skin anatomy Aesthetic Applications of Intense Pulsed Light ed L Fodor and Y Ullmann (Springer) pp 1–12
[2] [2] Weng T T et al 2021 3D bioprinting for skin tissue engineering: current status and perspectives J. Tissue Eng.12 20417314211028574
[3] [3] Park W, Gao G and Cho DW 2021 Tissue-specific decellularized extracellular matrix bioinks for musculoskeletal tissue regeneration and modeling using 3D bioprinting technology Int. J. Mol. Sci.22 7837
[4] [4] Yan WC, Davoodi P, Vijayavenkataraman S, Tian Y, Ng W C, Fuh J Y H, Robinson K S and Wang CH 2018 3D bioprinting of skin tissue: from pre-processing to final product evaluation Adv. Drug Deliv. Rev.132 270–295
[5] [5] Cai R X, Gimenez-Camino N, Xiao M, Bi S G and Divito K A 2023 Technological advances in three-dimensional skin tissue engineering Rev. Adv. Mater. Sci.62 20220289
[6] [6] Kamadjaja D 2017 Tissue engineering in maxillofacial bone reconstruction J. Stem Cell Res. Tissue Eng.1 27–28
[7] [7] Zhang Z F, Feng Y H, Wang L, Liu D X, Qin C C and Shi Y B 2022 A review of preparation methods of porous skin tissue engineering scaffolds Mater. Today Commun.32 104109
[8] [8] Fernandes S, Vyas C, Lim P, Pereira R F, Virs A and Brtolo P 2022 3D bioprinting: an enabling technology to understand melanoma Cancers14 3535
[9] [9] Ng W L, Qi J T Z, Yeong W Y and Naing M W 2018 Proof-of-concept: 3D bioprinting of pigmented human skin constructs Biofabrication10 025005
[10] [10] Pourchet L J, Thepot A, Albouy M, Courtial E J, Boher A, Blum L J and Marquette C A 2017 Human skin 3D bioprinting using scaffold-free approach Adv. Healthcare Mater.6 1601101
[11] [11] Lee HR, Park J A, Kim S, Jo Y, Kang D and Jung S 2021 3D microextrusion-inkjet hybrid printing of structured human skin equivalents Bioprinting22 e00143
[12] [12] El-Serafi A T, El-Serafi I T, Elmasry M, Steinvall I and Sjberg F 2017 Skin regeneration in three dimensions, current status, challenges and opportunities Differentiation96 26–29
[13] [13] Zhang B, Luo Y C, Ma L, Gao L, Li Y T, Xue Q, Yang H Y and Cui Z F 2018 3D bioprinting: an emerging technology full of opportunities and challenges Bio-Des. Manuf.1 2–13
[14] [14] Chameettachal S, Yeleswarapu S, Sasikumar S, Shukla P, Hibare P, Bera A K, Bojedla S S R and Pati F 2019 3D bioprinting: recent trends and challenges J. Indian Inst. Sci.99 375–403
[15] [15] Ozbolat I T 2016 3D Bioprinting: Fundamentals, Principles and Applications (Academic)
[16] [16] Mehrotra P 2016 Biosensors and their applications—a review J. Oral Biol. Craniofac. Res.6 153–159
[17] [17] Hasan A, Nurunnabi M, Morshed M, Paul A, Polini A, Kuila T, Al Hariri M, Lee YK and Jaffa A A 2014 Recent advances in application of biosensors in tissue engineering BioMed Res. Int.2014 307519
[18] [18] Ramesh M, Janani R, Deepa C and Rajeshkumar L 2023 Nanotechnology-enabled biosensors: a review of fundamentals, design principles, materials, and applications Biosensors13 40
[19] [19] Xie Z L, Gao M, Lobo A O and Webster T J 2020 3D bioprinting in tissue engineering for medical applications: the classic and the hybrid Polymers12 1717
[20] [20] Shopova D, Yaneva A, Bakova D, Mihaylova A, Kasnakova P, Hristozova M, Sbirkov Y, Sarafian V and Semerdzhieva M 2023 (Bio)printing in personalized medicine—opportunities and potential benefits Bioengineering10 287
[21] [21] Kanitakis J 2002 Anatomy, histology and immunohistochemistry of normal human skin Eur. J. Dermatol.12 390–9
[22] [22] Halprin K M 1972 Epidermal “turnover time”—a re-examination Br. J. Dermatol.86 14–19
[23] [23] Kumar M S A 2024 The skin Techniques in Small Animal Wound Management ed N J Buote (Wiley) pp 1–27
[24] [24] Holte K and Biswas A 2020 The skin Muir's Textbook of Pathology 16th edn, ed C S Herrington (CRC Press) p 37
[25] [25] Chu D H 2012 Overview of biology, development, and structure of skin Fitzpatrick's Dermatology in General Medicine 8th edn, ed K Wolff, L A Goldsmith, S I Katz, B A Gilchrest, A S Paller and D J Leffell (McGraw-Hill) pp 57–73
[26] [26] Watt F M, Crompton M J, Dexter T M and Wright N A 1998 Epidermal stem cells: markers, patterning and the control of stem cell fate Phil. Trans. R. Soc. B 353 831–837
[27] [27] Walko G, Castan M J and Wiche G 2015 Molecular architecture and function of the hemidesmosome Cell Tissue Res.360 529–544
[28] [28] Cichorek M, Wachulska M, Stasiewicz A and Tymiska A 2013 Skin melanocytes: biology and development Postepy Dermatol. Alergol.30 30–41
[29] [29] Haass N K and Herlyn M 2005 Normal human melanocyte homeostasis as a paradigm for understanding melanoma J. Investig. Dermatol. Symp. Proc.10 153–163
[30] [30] Yousef H, Alhajj M and Sharma S 2020 Anatomy, skin (integument), epidermis StatPearls (StatPearls Publishing) (available at: www.ncbi.nlm.nih.gov/books/NBK470464/)
[31] [31] Hashemi P, Pulitzer M P, Scope A, Kovalyshyn I, Halpern A C and Marghoob A A 2012 Langerhans cells and melanocytes share similar morphologic features under in vivo reflectance confocal microscopy: a challenge for melanoma diagnosis J. Am. Acad. Dermatol.66 452–462
[32] [32] Bliss D 2005 Layers of the skin (National Cancer Institute) (available at: https://visualsonline.cancer.gov/details.cfm?imageid=4362)
[33] [33] Peltonen S, Raiko L, Peltonen J and Mueller E J 2010 Desmosomes in developing human epidermis Dermatol. Res. Pract.2010 698761
[34] [34] Roger M et al 2019 Bioengineering the microanatomy of human skin J. Anat.234 438–455
[35] [35] Arda O, Gksgr N and Tzn Y 2014 Basic histological structure and functions of facial skin Clin. Dermatol.32 3–13
[36] [36] Jaitley S and Saraswathi T R 2012 Pathophysiology of Langerhans cells J. Oral Maxillofac. Pathol.16 239–244
[37] [37] Breathnach A S 1977 Variations in ultrastructural appearance of Langerhans cells of normal human epidermis Br. J. Dermatol.97 14
[38] [38] Matoltsy A G 1976 Keratinization J. Invest. Dermatol.67 20–25
[39] [39] Kolarsick P A J, Kolarsick M A and Goodwin C 2011 Anatomy and physiology of the skin J. Dermatol. Nurses′ Assoc.3 203–213
[40] [40] Nguyen A V and Soulika A M 2019 The dynamics of the skin's immune system Int. J. Mol. Sci.20 1811
[41] [41] Elias P M 2012 Structure and function of the stratum corneum extracellular matrix J. Invest. Dermatol.132 2131–3
[42] [42] Nicol N H 2005 Anatomy and physiology of the skin J. Dermatol. Nurses17 62
[43] [43] Mauldin E A and Peters-Kennedy J 2016 Integumentary system Jubb, Kennedy & Palmer's Pathology of Domestic Animals: Volume 1 6th edn, ed M G Maxie (Elsevier) ch 6, pp 509–736.e1
[44] [44] Amirlak B 2017 Skin anatomy: overview, epidermis, dermis (Medscape) (available at: https://emedicine.medscape.com/article/1294744-overview)
[45] [45] Brown T M and Krishnamurthy K 2019 Histology, dermis StatPearls (Treasure Island (FL)) (available at: www.ncbi.nlm.nih.gov/books/NBK535346/)
[46] [46] Haydont V, Bernard B A and Fortunel N O 2019 Age-related evolutions of the dermis: clinical signs, fibroblast and extracellular matrix dynamics Mech. Ageing Dev.177 150–156
[47] [47] Marks R, Knight A and Laidler P 1986 Atlas of Skin Pathology (Springer)
[48] [48] Monteiro-Riviere N A 1991 Comparative anatomy, physiology, and biochemistry of mammalian skin Dermal and Ocular Toxicology ed D W Hobson (CRC Press)
[49] [49] Rodrigues M, Kosaric N, Bonham C A and Gurtner G C 2019 Wound healing: a cellular perspective Physiol. Rev.99 665–706
[50] [50] Darby I A, Laverdet B, Bont F and Desmoulire A 2014 Fibroblasts and myofibroblasts in wound healing Clin. Cosmet. Investig. Dermatol.7 301–311
[51] [51] Tottoli E M, Dorati R, Genta I, Chiesa E, Pisani S and Conti B 2020 Skin wound healing process and new emerging technologies for skin wound care and regeneration Pharmaceutics12 735
[52] [52] Hao R N, Cui Z Y, Zhang X D, Tian M, Zhang L Q, Rao F and Xue J J 2022 Rational design and preparation of functional hydrogels for skin wound healing Front. Chem.9 839055
[53] [53] Sorg H, Tilkorn D J, Hager S, Hauser J and Mirastschijski U 2017 Skin wound healing: an update on the current knowledge and concepts Eur. Surg. Res.58 81–94
[54] [54] Goldman R 2004 Growth factors and chronic wound healing: past, present, and future Adv. Skin Wound Care17 24–35
[55] [55] Zhao R L, Liang H, Clarke E, Jackson C and Xue M L 2016 Inflammation in chronic wounds Int. J. Mol. Sci.17 2085
[56] [56] Zeng R J, Lin C Q, Lin Z H, Chen H, Lu W Y, Lin C M and Li H H 2018 Approaches to cutaneous wound healing: basics and future directions Cell Tissue Res.374 217–232
[57] [57] Eming S A, Martin P and Tomic-Canic M 2014 Wound repair and regeneration: mechanisms, signaling, and translation Sci. Transl. Med.6 265sr6
[58] [58] Almeida D, Sanjuan-Alberte P, Silva J C and Ferreira F C 2024 3D (bio)printing of magnetic hydrogels: formulation and applications in tissue engineering Int. J. Biosci.10 0965
[59] [59] Germain N, Dhayer M, Dekiouk S and Marchetti P 2022 Current advances in 3D bioprinting for cancer modeling and personalized medicine Int. J. Mol. Sci.23 3432
[60] [60] Hosseini B S T, Meadows K, Gabriel V, Hu J G and Kim K 2024 Biofabrication of cellulose-based hydrogels for advanced wound healing: a special emphasis on 3D bioprinting Macromol. Biosci.24 2300376
[61] [61] Umur E, Bayrak E, Arslan F, Bulut S B, Baysoy E, Kaleli-Can G and Ayan B 2023 Advances in three dimensional bioprinting for wound healing: a comprehensive review Appl. Sci.13 10269
[62] [62] Raffetto J D, Ligi D, Maniscalco R, Khalil R A and Mannello F 2021 Why venous leg ulcers have difficulty healing: overview on pathophysiology, clinical consequences, and treatment J. Clin. Med.10 29
[63] [63] Bishop E S, Mostafa S, Pakvasa M, Luu H H, Lee M J, Wolf J M, Ameer G A, He TC and Reid R R 2017 3-D bioprinting technologies in tissue engineering and regenerative medicine: current and future trends Genes Dis.4 185–195
[64] [64] Fayyazbakhsh F and Leu M C 2020 A brief review on 3D bioprinted skin substitutes Proc. Manuf.48 790–796
[65] [65] Kang M S, Jang J, Jo H J, Kim WH, Kim B, Chun HJ, Lim D and Han DW 2023 Advances and innovations of 3D bioprinting skin Biomolecules13 55
[66] [66] Masson J C 1918 Skin grafting JAMA70 1581–1584
[67] [67] Andreassi A, Bilenchi R, Biagioli M and D'Aniello C 2005 Classification and pathophysiology of skin grafts Clin. Dermatol.23 332–337
[68] [68] Valencia I C, Falabella A F and Eaglstein W H 2000 Skin grafting Dermatol. Clin.18 521–532
[69] [69] Barrati G E and Koopmann J C F 1984 Skin grafts: physiology and clinical considerations Otolaryngol. Clin. North Am.17 335–353
[70] [70] Khan A A, Khan I M, Nguyen P P, Lo E, Chahadeh H, Cerniglia M and Noriega J A 2020 Skin graft techniques Clin. Podiatr. Med. Surg.37 821–835
[71] [71] Adams D C and Ramsey M L 2005 Grafts in dermatologic surgery: review and update on full- and split-thickness skin grafts, free cartilage grafts, and composite grafts Dermatol. Surg.31 1055–1067
[72] [72] Kimura N 2002 A microdissected thin tensor fasciae latae perforator flap Plast. Reconstr. Surg.109 69–77
[73] [73] Koshima I, Inagawa K, Urushibara K and Moriguchi T 1998 Paraumbilical perforator flap without deep inferior epigastric vessels Plast. Reconstr. Surg.102 1052–1057
[74] [74] Kim E and Drew P J 2022 Management of burn injury Surgery40 62–69
[75] [75] Snchez P F, Brey E M and Briceo J C 2018 Endothelialization mechanisms in vascular grafts J. Tissue Eng. Regener. Med.12 2164–2178
[76] [76] Bennett L 2007 Elastic Fibre Deposition in Healing Wounds and A Dermal Substitute, and the Consequences for Skin Grafting (University of Manchester)
[77] [77] Adigbli G, Alshomer F, Maksimcuka J and Ghali S 2016 Principles of plastic surgery, wound healing, skin grafts and flaps Textbook of Plastic and Reconstructive Surgery ed D M Kalaskar, P E Butler and S Ghali (UCL Press)
[78] [78] Guogien I, Kievias M, Grigait A, Braziulis K and Rimdeika R 2018 Split-thickness skin grafting: early outcomes of a clinical trial using different graft thickness J. Wound Care27 5–13
[79] [79] Dai C, Shih S and Khachemoune A 2020 Skin substitutes for acute and chronic wound healing: an updated review J. Dermatol. Treat.31 639–648
[80] [80] Boyce S T 1996 Cultured skin substitutes: a review Tissue Eng.2 255–266
[81] [81] Boyce S T 2001 Design principles for composition and performance of cultured skin substitutes Burns27 523–533
[82] [82] Nyame T T, Chiang H A and Orgill D P 2014 Clinical applications of skin substitutes Surg. Clin. North Am.94 839–850
[83] [83] European Commission Ban on animal testing (available at: https://single-market-economy.ec.europa.eu/sectors/cosmetics/ban-animal-testing_en)
[84] [84] Powley T 2015 Procter & Gamble puts skin in 3D bioprinting game (Financial Times) (available at: www.ft.com/content/02809474-ffe8-11e4-abd5-00144feabdc0)
[85] [85] Sher D 2016 L'Oral partners with poietis to develop 3D printed hair follicles (VoxelMatters) (available at: www.voxelmatters.com/loreal-partners-poietis-develop-3d-printed-hair-follicles/)
[86] [86] L'Oral Groupe Revolutionizing tissue engineering (available at: www.loreal.com/en/news/research-innovation/revolutionizing-tissue-engineering/)
[87] [87] Anon 2023 Chanel and LabSkin create 3D bioprinted skin with pigmentation spots (available at: www.premiumbeautynews.com/en/chanel-and-labskin-create-3d,21634)
[88] [88] Madeleine P 2023 Chanel has developed 3D bioprinted skin to improve its skincare projects (available at: www.3dnatives.com/en/chanel-has-developed-3d-bioprinted-skin-270220234/)
[89] [89] Mari A 2023 Brazil's grupo boticrio develops 3D skin with bioprinting technology (available at: www.forbes.com/sites/angelicamarideoliveira/2023/12/08/brazils-grupo-boticrio-develops-3d-skin-with-bioprinting-technology/)
[90] [90] CTIBiotech 3D bioprinted human skin—the future of cosmetic testing (available at: https://bico.com/blog/3d-bioprinted-human-skin-the-future-of-cosmetic-testing/)
[91] [91] Sher D 2019 BASF and CTIBiotech to Develop First Regenerating 3D Bioprinted Human Skin Model (available at: www.basf.com/global/en/media/news-releases/2019/09/p-19-318)
[92] [92] JALA Group 2017 JALA group announces successful printing of Asian skin using 3D bioprinting technology (available at: www.prnewswire.com/news-releases/jala-group-announces-successful-printing-of-asian-skin-using-3d-bioprinting-technology-300407828.html)
[93] [93] Listek V 2020 Bioprinted skin patches for diabetic foot ulcers commercialized by rokit healthcare (available at: https://3dprint.com/269464/bioprinted-skin-patches-for-diabetic-foot-ulcers-commercialized-by-rokit-healthcare/)
[94] [94] Lee H J 2019 An interview with Heon Ju Lee on ROCKIT Healthcare's novel bioprinting treatment for dermal scarring J. 3D Print. Med.3 111–113
[95] [95] Hancock A 2023 3D bioprinting market size, share & trends analysis report by 2030 (Vantage Market Research) (available at: www.linkedin.com/pulse/3d-bioprinting-market-size-share-trends-analysis-report-hancock)
[96] [96] Combellack E, Jessop Z M and Whitaker I S 2018 The commercial 3D bioprinting industry 3D Bioprinting for Reconstructive Surgery: Techniques and Applications ed D J Thomas, Z M Jessop and I S Whitaker (Woodhead Publishing) pp 413–421
[97] [97] Kang HW, Lee S J, Ko I K, Kengla C, Yoo J J and Atala A 2016 A 3D bioprinting system to produce human-scale tissue constructs with structural integrity Nat. Biotechnol.34 312–319
[98] [98] Ozbolat I T and Hospodiuk M 2016 Current advances and future perspectives in extrusion-based bioprinting Biomaterials76 321–343
[99] [99] Hlzl K, Lin S M, Tytgat L, Van Vlierberghe S, Gu L X and Ovsianikov A 2016 Bioink properties before, during and after 3D bioprinting Biofabrication8 032002
[100] [100] Derakhshanfar S, Mbeleck R, Xu K G, Zhang X Y, Zhong W and Xing M 2018 3D bioprinting for biomedical devices and tissue engineering: a review of recent trends and advances Bioact. Mater.3 144–156
[101] [101] Cubo N, Garcia M, Del Caizo J F, Velasco D and Jorcano J L 2017 3D bioprinting of functional human skin: production and in vivo analysis Biofabrication9 015006
[102] [102] Rimann M, Bono E, Annaheim H, Bleisch M and Graf-Hausner U 2016 Standardized 3D bioprinting of soft tissue models with human primary cells J. Lab. Autom.21 496–509
[103] [103] Admane P, Gupta A C, Jois P, Roy S, Lakshmanan C C, Kalsi G, Bandyopadhyay B and Ghosh S 2019 Direct 3D bioprinted full-thickness skin constructs recapitulate regulatory signaling pathways and physiology of human skin Bioprinting15 e00051
[104] [104] Kim B S, Gao G, Kim J Y and Cho DW 2019 3D cell printing of perfusable vascularized human skin equivalent composed of epidermis, dermis, and hypodermis for better structural recapitulation of native skin Adv. Healthcare Mater.8 1801019
[105] [105] Ramesh S, Harrysson O L A, Rao P K, Tamayol A, Cormier D R, Zhang Y B and Rivero I V 2021 Extrusion bioprinting: recent progress, challenges, and future opportunities Bioprinting21 e00116
[106] [106] Chand R, Muhire B S and Vijayavenkataraman S 2022 Computational fluid dynamics assessment of the effect of bioprinting parameters in extrusion bioprinting Int. J. Bioprinting8 545
[107] [107] Boularaoui S, Al Hussein G, Khan K A, Christoforou N and Stefanini C 2020 An overview of extrusion-based bioprinting with a focus on induced shear stress and its effect on cell viability Bioprinting20 e00093
[108] [108] Ning L Q, Betancourt N, Schreyer D J and Chen X B 2018 Characterization of cell damage and proliferative ability during and after bioprinting ACS Biomater. Sci. Eng.4 3906–3918
[109] [109] Emmermacher J, Spura D, Cziommer J, Kilian D, Wollborn T, Fritsching U, Steingroewer J, Walther T, Gelinsky M and Lode A 2020 Engineering considerations on extrusion-based bioprinting: interactions of material behavior, mechanical forces and cells in the printing needle Biofabrication12 025022
[110] [110] Gerdes S, Ramesh S, Mostafavi A, Tamayol A, Rivero I V and Rao P 2021 Extrusion-based 3D (Bio)printed tissue engineering scaffolds: process-structure-quality relationships ACS Biomater. Sci. Eng.7 4694–4717
[111] [111] Chung J H Y, Naficy S, Yue Z L, Kapsa R, Quigley A, Moulton S E and Wallace G G 2013 Bio-ink properties and printability for extrusion printing living cells Biomater. Sci.1 763–773
[112] [112] Li Q, Zhang B, Xue Q, Zhao C X, Luo Y C, Zhou H Z, Ma L, Yang H Y and Bai D P 2021 A systematic thermal analysis for accurately predicting the extrusion printability of alginate-gelatin-based hydrogel bioinks Int. J. Bioprinting7 394
[113] [113] Ng W L, Wang S, Yeong W Y and Naing M W 2016 Skin bioprinting: impending reality or fantasy? Trends Biotechnol.34 689–699
[114] [114] Murry C E and Keller G 2008 Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development Cell132 661–680
[115] [115] Moncal K K et al 2021 Tissue engineering: intra-operative bioprinting of hard, soft, and hard/soft composite tissues for craniomaxillofacial reconstruction Adv. Funct. Mater.31 2170212
[116] [116] Lee W, Lee V, Polio S, Keegan P, Lee JH, Fischer K, Park JK and Yoo SS 2010 On-demand three-dimensional freeform fabrication of multi-layered hydrogel scaffold with fluidic channels Biotechnol. Bioeng.105 1178–1186
[117] [117] Koch L et al 2012 Skin tissue generation by laser cell printing Biotechnol. Bioeng.109 1855–1863
[118] [118] Shin S, Kwak H and Hyun J 2018 Melanin nanoparticle-incorporated silk fibroin hydrogels for the enhancement of printing resolution in 3D-projection stereolithography of poly(ethylene glycol)-tetraacrylate bio-ink ACS Appl. Mater. Interfaces10 23573–23582
[119] [119] Kang Y, Yeo M, Derman I D, Ravnic D J, Singh Y P, Alioglu M A, Wu Y, Makkar J, Driskell R R and Ozbolat I T 2024 Intraoperative bioprinting of human adipose-derived stem cells and extra-cellular matrix induces hair follicle-like downgrowths and adipose tissue formation during full-thickness craniomaxillofacial skin reconstruction Bioact. Mater.33 114–128
[120] [120] Li X D, Liu B X, Pei B, Chen J W, Zhou D Z, Peng J Y, Zhang X Z, Jia W and Xu T 2020 Inkjet bioprinting of biomaterials Chem. Rev.120 10793–10833
[121] [121] Rayleigh L 1891 Some applications of photography Nature44 249–254
[122] [122] Derby B 2008 Bioprinting: inkjet printing proteins and hybrid cell-containing materials and structures J. Mater. Chem.18 5717–5721
[123] [123] Sweet R G 1965 High frequency recording with electrostatically deflected ink jets Rev. Sci. Instrum.36 131–136
[124] [124] Schneider J M and Hendricks C D 1964 Source of uniform-sized liquid droplets Rev. Sci. Instrum.35 1349–1350
[125] [125] Gudapati H, Dey M and Ozbolat I 2016 A comprehensive review on droplet-based bioprinting: past, present and future Biomaterials102 20–42
[126] [126] Derby B 2010 Inkjet printing of functional and structural materials: fluid property requirements, feature stability, and resolution Annu. Rev. Mater. Res.40 395–414
[127] [127] Ng W L and Shkolnikov V 2024 Optimizing cell deposition for inkjet-based bioprinting Int. J. Biosci.10 2135
[128] [128] Takagi D, Lin W, Matsumoto T, Yaginuma H, Hemmi N, Hatada S and Seo M 2019 High-precision three-dimensional inkjet technology for live cell bioprinting Int. J. Bioprinting5 208
[129] [129] Cui X F, Boland T, D'Lima D D and Lotz M K 2012 Thermal inkjet printing in tissue engineering and regenerative medicin Recent Pat. Drug Deliv. Formul.6 149–155
[130] [130] Lee W, Debasitis J C, Lee V K, Lee J H, Fischer K, Edminster K, Park J K and Yoo S S 2009 Multi-layered culture of human skin fibroblasts and keratinocytes through three-dimensional freeform fabrication Biomaterials30 1587–1595
[131] [131] Skardal A, Mack D, Kapetanovic E, Atala A, Jackson J D, Yoo J and Soker S 2012 Bioprinted amniotic fluid-derived stem cells accelerate healing of large skin wounds Stem Cells Transl. Med.1 792–802
[132] [132] Yanez M, Rincon J, Dones A, De Maria C, Gonzales R and Boland T 2015 In vivo assessment of printed microvasculature in a bilayer skin graft to treat full-thickness wounds Tissue Eng. A 21 224–233
[133] [133] Lee SG, Lee S, Bae HK, Lee K Y, Park C, Kim M S, Lee D H, Chung H M and Kim CY 2024 Evaluation of the therapeutic efficacy of human skin equivalents manufactured through droplet-based bioprinting/nebulization technology Mol. Cell Toxicol.20 129–138
[134] [134] Lee V, Singh G, Trasatti J P, Bjornsson C, Xu X W, Tran T N, Yoo SS, Dai G H and Karande P 2014 Design and fabrication of human skin by three-dimensional bioprinting Tissue Eng. C 20 473–484
[135] [135] Kim B S, Lee JS, Gao G and Cho DW 2017 Direct 3D cell-printing of human skin with functional transwell system Biofabrication9 025034
[136] [136] Persaud A, Maus A, Strait L and Zhu D H 2022 3D bioprinting with live cells Eng. Regener.3 292–309
[137] [137] Lee V K and Dai G H 2017 Printing of three-dimensional tissue analogs for regenerative medicine Ann. Biomed. Eng.45 115–131
[138] [138] Li M G, Tian X Y, Schreyer D J and Chen X B 2011 Effect of needle geometry on flow rate and cell damage in the dispensing-based biofabrication process Biotechnol. Prog.27 1777–1784
[139] [139] Lee J M, Ng W L and Yeong W Y 2019 Resolution and shape in bioprinting: strategizing towards complex tissue and organ printing Appl. Phys. Rev.6 011307
[140] [140] Blaeser A, Campos D F D, Puster U, Richtering W, Stevens M M and Fischer H 2016 Controlling shear stress in 3D bioprinting is a key factor to balance printing resolution and stem cell integrity Adv. Healthcare Mater.5 326–333
[141] [141] Ng W L, Xi H, Shkolnikov V, Goh G L, Suntornnond R and Yeong W Y 2021 Controlling droplet impact velocity and droplet volume: key factors to achieving high cell viability in sub-nanoliter droplet-based bioprinting Int. J. Bioprinting8 424
[142] [142] Graham A D, Olof S N, Burke M J, Armstrong J P K, Mikhailova E A, Nicholson J G, Box S J, Szele F G, Perriman A W and Bayley H 2017 High-resolution patterned cellular constructs by droplet-based 3D printing Sci. Rep.7 7004
[143] [143] Ozbolat I T 2017 5-Droplet-based bioprinting 3D Bioprinting ed I T Ozbolat (Academic) pp 125–163
[144] [144] Cheng E, Yu H R, Ahmadi A and Cheung K C 2016 Investigation of the hydrodynamic response of cells in drop on demand piezoelectric inkjet nozzles Biofabrication8 015008
[145] [145] Tayari K, Chaoui M, Ghariani H and Lahiani M 2014 Influence of the cardiac activity on the surface impedance of a multilayer model 2014 1st Int. Conf. Advanced Technologies for Signal and Image Processing (ATSIP) (IEEE) pp 340–5
[146] [146] Ventura R D 2021 An overview of laser-assisted bioprinting (LAB) in tissue engineering applications Med. Lasers10 76–81
[147] [147] Dou C R, Perez V, Qu J, Tsin A, Xu B and Li J Z 2021 A state-of-the-art review of laser-assisted bioprinting and its future research trends ChemBioEng Rev.8 517–534
[148] [148] Guillemot F, Souquet A, Catros S and Guillotin B 2010 Laser-assisted cell printing: principle, physical parameters versus cell fate and perspectives in tissue engineering Nanomedicine5 507–515
[149] [149] Krourdan O, Hakobyan D, Rmy M, Ziane S, Dusserre N, Fricain JC, Delmond S, Thbaud N B and Devillard R 2019 In situ prevascularization designed by laser-assisted bioprinting: effect on bone regeneration Biofabrication11 045002
[150] [150] Odde D J and Renn M J 2000 Laser-guided direct writing of living cells Biotechnol. Bioeng.67 312–318
[151] [151] Kawecki F, Clafshenkel W P, Auger F A, Bourget JM, Fradette J and Devillard R 2018 Self-assembled human osseous cell sheets as living biopapers for the laser-assisted bioprinting of human endothelial cells Biofabrication10 035006
[152] [152] Ozbolat I T 2017 6-Laser-based bioprinting 3D Bioprinting (Academic) pp 165–97
[153] [153] Catros S et al 2012 Layer-by-layer tissue microfabrication supports cell proliferation in vitro and in vivo Tissue Eng. C 18 62–70
[154] [154] Koch L et al 2010 Laser printing of skin cells and human stem cells Tissue Eng. C 16 847–854
[155] [155] Gruene M, Pflaum M, Deiwick A, Koch L, Schlie S, Unger C, Wilhelmi M, Haverich A and Chichkov B N 2011 Adipogenic differentiation of laser-printed 3D tissue grafts consisting of human adipose-derived stem cells Biofabrication3 015005
[156] [156] Michael S, Sorg H, Peck C T, Koch L, Deiwick A, Chichkov B, Vogt P M, Reimers K and Slominski A T 2013 Tissue engineered skin substitutes created by laser-assisted bioprinting form skin-like structures in the dorsal skin fold chamber in mice PLoS One8 e57741
[157] [157] Hopp B, Smausz T, Kresz N, Barna N, Bor Z, Kolozsvri L, Chrisey D B, Szab A and Ngrdi A 2005 Survival and proliferative ability of various living cell types after laser-induced forward transfer Tissue Eng.11 1817–23
[158] [158] Barron J A, Krizman D B and Ringeisen B R 2005 Laser printing of single cells: statistical analysis, cell viability, and stress Ann. Biomed. Eng.33 121–130
[159] [159] Ringeisen B R, Kim H, Barron J A, Krizman D B, Chrisey D B, Jackman S, Auyeung R Y C and Spargo B J 2004 Laser printing of pluripotent embryonal carcinoma cells Tissue Eng.10 483–491
[160] [160] Barron J A, Young H D, Dlott D D, Darfler M M, Krizman D B and Ringeisen B R 2005 Printing of protein microarrays via a capillary-free fluid jetting mechanism Proteomics5 4138–4144
[161] [161] Zhang Z Y, Xu C X, Xiong R T, Chrisey D B and Huang Y 2017 Effects of living cells on the bioink printability during laser printing Biomicrofluidics11 034120
[162] [162] Machekposhti S A, Movahed S and Narayan R J 2020 Physicochemical parameters that underlie inkjet printing for medical applications Biophys. Rev.1 011301
[163] [163] Li J P, Chen M J, Fan X Q and Zhou H F 2016 Recent advances in bioprinting techniques: approaches, applications and future prospects J. Transl. Med.14 271
[164] [164] Vijayavenkataraman S, Lu W F and Fuh J Y H 2016 3D bioprinting of skin: a state-of-the-art review on modelling, materials, and processes Biofabrication8 032001
[165] [165] Pitsillides C M, Joe E K, Wei X B, Anderson R R and Lin C P 2003 Selective cell targeting with light-absorbing microparticles and nanoparticles Biophys. J.84 4023–4032
[166] [166] Rider P, Kaarevi P, Alkildani S, Retnasingh S and Barbeck M 2018 Bioprinting of tissue engineering scaffolds J. Tissue Eng.9 2041731418802090
[167] [167] Murphy S V and Atala A 2014 3D bioprinting of tissues and organs Nat. Biotechnol.32 773–785
[168] [168] Pedde R D et al 2017 Emerging biofabrication strategies for engineering complex tissue constructs Adv. Mater.29 1606061
[169] [169] Wang Z J, Abdulla R, Parker B, Samanipour R, Ghosh S and Kim K 2015 A simple and high-resolution stereolithography-based 3D bioprinting system using visible light crosslinkable bioinks Biofabrication7 045009
[170] [170] Yeo M, Sarkar A, Singh Y P, Derman I D, Datta P and Ozbolat I T 2024 Synergistic coupling between 3D bioprinting and vascularization strategies Biofabrication16 012003
[171] [171] Shanjani Y, Pan C C, Elomaa L and Yang Y 2015 A novel bioprinting method and system for forming hybrid tissue engineering constructs Biofabrication7 045008
[172] [172] Raman R and Bashir R 2015 Stereolithographic 3D bioprinting for biomedical applications Essentials of 3D Biofabrication and Translation ed A Atala and J J Yoo (Academic Press an imprint of Elsevier) ch 6, pp 89–121
[173] [173] He Y, Gu Z M, Xie M J, Fu J Z and Lin H 2020 Why choose 3D bioprinting? Part II: methods and bioprinters Bio-Des. Manuf.3 1–4
[174] [174] Hafa L, Breideband L, Posada L R, Torras N, Martinez E, Stelzer E H K and Pampaloni F 2024 Light sheet-based laser patterning bioprinting produces long-term viable full-thickness skin constructs Adv. Mater.36 2306258
[175] [175] Fedorovich N E, Oudshoorn M H, van Geemen D, Hennink W E, Alblas J and Dhert W J A 2009 The effect of photopolymerization on stem cells embedded in hydrogels Biomaterials30 344–53
[176] [176] Wendland R J, Conway M T and Worthington K S 2024 Evaluating the polymerization effectiveness and biocompatibility of bio-sourced, visible light-based photoinitiator systems J. Biomed. Mater. Res. A 112 1662–1764
[177] [177] Ng W L, Lee J M, Zhou M M, Chen YW, Lee KX A, Yeong W Y and Shen YF 2020 Vat polymerization-based bioprinting—process, materials, applications and regulatory challenges Biofabrication12 022001
[178] [178] Levato R, Dudaryeva O, Garciamendez-Mijares C E, Kirkpatrick B E, Rizzo R, Schimelman J, Anseth K S, Chen S C, Zenobi-Wong M and Zhang Y S 2023 Light-based vat-polymerization bioprinting Nat. Rev. Methods Primers3 47
[179] [179] Bowser D A and Moore M J 2020 Biofabrication of neural microphysiological systems using magnetic spheroid bioprinting Biofabrication12 015002
[180] [180] Samandari M, Mostafavi A, Quint J, Memi A and Tamayol A 2022 In situ bioprinting: intraoperative implementation of regenerative medicine Trends Biotechnol.40 1229–1247
[181] [181] Wu Y, Ravnic D J and Ozbolat I T 2020 Intraoperative bioprinting: repairing tissues and organs in a surgical setting Trends Biotechnol.38 594–605
[182] [182] Campbell P G and Weiss L E 2007 Tissue engineering with the aid of inkjet printers Expert Opin. Biol. Ther.7 1123–1127
[183] [183] Binder K W, Zhao W X, Aboushwareb T, Dice D, Atala A and Yoo J J 2010 In situ bioprinting of the skin for burns J. Am. Coll. Surg.211 S76
[184] [184] Albanna M et al 2019 In situ bioprinting of autologous skin cells accelerates wound healing of extensive excisional full-thickness wounds Sci. Rep.9 1856
[185] [185] Albouy M et al 2022 A preliminary study for an intraoperative 3D bioprinting treatment of severe burn injuries Plast. Reconstr. Surg.10 e4056
[186] [186] Wang H C, Lian Q, Li D C, Li C H, Zhao T Z and Liang J 2021 Multi-tissue layering and path planning of in situ bioprinting for complex skin and soft tissue defects Rapid Prototyp. J.27 321–332
[187] [187] Jamrz W, Szafraniec J, Kurek M and Jachowicz R 2018 3D printing in pharmaceutical and medical applications—recent achievements and challenges Pharm. Res.35 176
[188] [188] Ajith G, Goyal A S, Rodrigues F C and Thakur G 2021 12-Natural Polysaccharides for Wound Healing. Food, Medical, and Environmental Applications of Polysaccharides ed K Pal, I Banerjee, P Sarkar, A Bit, D Kim, A Anis and S Maji (Elsevier) pp 341–79
[189] [189] Onder O C, Batool S R and Nazeer M A 2022 Self-assembled silk fibroin hydrogels: from preparation to biomedical applications Mater. Adv.3 6920–49
[190] [190] Hakimi N, Cheng R, Leng L, Sotoudehfar M, Ba P Q, Bakhtyar N, Amini-Nik S, Jeschke M G and Gnther A 2018 Handheld skin printer: in situ formation of planar biomaterials and tissues Lab Chip18 1440–1451
[191] [191] Ashammakhi N, Ahadian S, Pountos I, Hu SK, Tellisi N, Bandaru P, Ostrovidov S, Dokmeci M R and Khademhosseini A 2019 In situ three-dimensional printing for reparative and regenerative therapy Biomed. Microdevices21 42
[192] [192] Singh S, Choudhury D, Yu F, Mironov V and Naing M W 2020 In situ bioprinting—bioprinting from benchside to bedside? Acta Biomater.101 14–25
[193] [193] Gungor-Ozkerim P S, Inci I, Zhang Y S, Khademhosseini A and Dokmeci M R 2018 Bioinks for 3D bioprinting: an overview Biomater. Sci.6 915–946
[194] [194] Yin J, Yan M L, Wang Y C, Fu J Z and Suo H R 2018 3D bioprinting of low-concentration cell-laden gelatin methacrylate (GelMA) bioinks with a two-step cross-linking strategy ACS Appl. Mater. Interfaces10 6849–6857
[195] [195] Masri S and Fauzi M B 2021 Current insight of printability quality improvement strategies in natural-based bioinks for skin regeneration and wound healing Polymers13 1011
[196] [196] Karvinen J and Kellomki M 2024 3D-bioprinting of self-healing hydrogels Eur. Polym. J.209 112864
[197] [197] Ramiah P, du Toit L C, Choonara Y E, Kondiah P P D and Pillay V 2020 Hydrogel-based bioinks for 3D bioprinting in tissue regeneration Front. Mater.7 76
[198] [198] Ullah F et al 2023 Development of highly-reproducible hydrogel based bioink for regeneration of skin-tissues via 3-D bioprinting technology Int. J. Biol. Macromol.230 123131
[199] [199] He P, Zhao J N, Zhang J M, Li B, Gou Z Y, Gou M L and Li X L 2018 Bioprinting of skin constructs for wound healing Burns Trauma6 5
[200] [200] Melchels F P W, Domingos M A N, Klein T J, Malda J, Bartolo P J and Hutmacher D W 2012 Additive manufacturing of tissues and organs Prog. Polym. Sci.37 1079–1104
[201] [201] Gao T, Gillispie G J, Copus J S, Pr A K, Seol YJ, Atala A, Yoo J J and Lee S J 2018 Optimization of gelatin-alginate composite bioink printability using rheological parameters: a systematic approach Biofabrication10 034106
[202] [202] Gelse K, Pschl E and Aigner T 2003 Collagens—structure, function, and biosynthesis Adv. Drug Deliv. Rev.55 1531–1546
[203] [203] Burgeson R E and Nimni M E 1992 Collagen types. molecular structure and tissue distribution Clin. Orthop. Relat. Res.282 250–72
[204] [204] Chevallay B and Herbage D 2000 Collagen-based biomaterials as 3D scaffold for cell cultures: applications for tissue engineering and gene therapy Med. Biol. Eng. Comput.38 211–218
[205] [205] Dong C J and Lv Y G 2016 Application of collagen scaffold in tissue engineering: recent advances and new perspectives Polymers8 42
[206] [206] Shpichka A, Butnaru D, Bezrukov E A, Sukhanov R B, Atala A, Burdukovskii V, Zhang Y Y and Timashev P 2019 Skin tissue regeneration for burn injury Stem Cell Res. Ther.10 94
[207] [207] Mathew-Steiner S S, Roy S and Sen C K 2021 Collagen in wound healing Bioengineering8 63
[208] [208] Nocera A D, Comn R, Salvatierra N A and Cid M P 2018 Development of 3D printed fibrillar collagen scaffold for tissue engineering Biomed. Microdevices20 26
[209] [209] Yazdanpanah Z, Johnston J D, Cooper D M L and Chen X B 2022 3D bioprinted scaffolds for bone tissue engineering: state-of-the-art and emerging technologies Front. Bioeng. Biotechnol.10 824156
[210] [210] Adhikari J, Roy A, Das A, Ghosh M, Thomas S, Sinha A, Kim J and Saha P 2021 Effects of processing parameters of 3D bioprinting on the cellular activity of bioinks Macromol. Biosci.21 2000179
[211] [211] Stepanovska J, Supova M, Hanzalek K, Broz A and Matejka R 2021 Collagen bioinks for bioprinting: a systematic review of hydrogel properties, bioprinting parameters, protocols, and bioprinted structure characteristics Biomedicines9 1137
[212] [212] Xu F, Dawson C, Lamb M, Mueller E, Stefanek E, Akbari M and Hoare T 2022 Hydrogels for tissue engineering: addressing key design needs toward clinical translation Front. Bioeng. Biotechnol.10 849831
[213] [213] Tripathi D, Sharma A, Tyagi P, Beniwal C S, Mittal G, Jamini A, Singh H and Tyagi A 2021 Fabrication of three-dimensional bioactive composite scaffolds for hemostasis and wound healing AAPS PharmSciTech22 138
[214] [214] Osidak E O et al 2019 Viscoll collagen solution as a novel bioink for direct 3D bioprinting J. Mater. Sci., Mater. Med.30 31
[215] [215] Khan M M R, Amin M K and Chakraborty N 2023 Advances and prospects of biodegradable polymer nanocomposites for fuel cell applications Biodegradable and Biocompatible Polymer Nanocomposites: Processing, Characterization, and Applications ed K Deshmukh and M Pandey (Elsevier) ch 17, pp 599–637
[216] [216] Kokol V, Pottathara Y B, Miheli M and Pere L S 2021 Rheological properties of gelatine hydrogels affected by flow- and horizontally-induced cooling rates during 3D cryo-printing Colloids Surf. A 616 126356
[217] [217] Klouda L and Mikos A G 2008 Thermoresponsive hydrogels in biomedical applications Eur. J. Pharm. Biopharm.68 34–45
[218] [218] Wang X H, Ao Q, Tian X H, Fan J, Tong H, Hou W J and Bai S L 2017 Gelatin-based hydrogels for organ 3D bioprinting Polymers9 401
[219] [219] Dell A C, Wagner G, Own J and Geibel J P 2022 3D bioprinting using hydrogels: cell inks and tissue engineering applications Pharmaceutics14 2596
[220] [220] Kaarevi P, Rider P M, Alkildani S, Retnasingh S, Smeets R, Jung O, Ivanievi Z and Barbeck M 2018 An introduction to 3D bioprinting: possibilities, challenges and future aspects Materials11 2199
[221] [221] Li H J, Tan C and Li L 2018 Review of 3D printable hydrogels and constructs Mater. Des.159 20–38
[222] [222] Xu L et al 2023 Bioprinting a skin patch with dual-crosslinked gelatin (GelMA) and silk fibroin (SilMA): an approach to accelerating cutaneous wound healing Mater. Today Bio18 100550
[223] [223] Ng W L, Yeong W Y and Naing M W 2016 Polyelectrolyte gelatin-chitosan hydrogel optimized for 3D bioprinting in skin tissue engineering Int. J. Bioprinting2 53–62
[224] [224] Piola B, Sabbatini M, Gino S, Invernizzi M and Ren F 2022 3D bioprinting of gelatin–xanthan gum composite hydrogels for growth of human skin cells Int. J. Mol. Sci.23 539
[225] [225] Dzobo K, Motaung K S C M and Adesida A 2019 Recent trends in decellularized extracellular matrix bioinks for 3D printing: an updated review Int. J. Mol. Sci.20 4628
[226] [226] Kabirian F and Mozafari M 2020 Decellularized ECM-derived bioinks: prospects for the future Methods171 108–118
[227] [227] Jiang S J, Zhuang Y, Cai M, Wang X D and Lin K L 2023 Decellularized extracellular matrix: a promising strategy for skin repair and regeneration Eng. Regener.4 357–74
[228] [228] Di Piazza E, Pandolfi E, Cacciotti I, Del Fattore A, Tozzi A E, Secinaro A and Borro L 2021 Bioprinting technology in skin, heart, pancreas and cartilage tissues: progress and challenges in clinical practice Int. J. Environ. Res. Public Health18 10806
[229] [229] Kim B S, Das S, Jang J and Cho DW 2020 Decellularized extracellular matrix-based bioinks for engineering tissue-and organ-specific microenvironments Chem. Rev.120 10608–10661
[230] [230] Pati F, Ha DH, Jang J, Han H H, Rhie JW and Cho DW 2015 Biomimetic 3D tissue printing for soft tissue regeneration Biomaterials62 164–75
[231] [231] Choudhury D, Tun H W, Wang T Y and Naing M W 2018 Organ-derived decellularized extracellular matrix: a game changer for bioink manufacturing? Trends Biotechnol.36 787–805
[232] [232] Khoshnood N and Zamanian A 2020 Decellularized extracellular matrix bioinks and their application in skin tissue engineering Bioprinting20 e00095
[233] [233] Jorgensen A M, Chou Z S, Gillispie G, Lee S J, Yoo J J, Soker S and Atala A 2020 Decellularized skin extracellular matrix (dsECM) improves the physical and biological properties of fibrinogen hydrogel for skin bioprinting applications Nanomaterials10 1484
[234] [234] Jang K S et al 2021 Therapeutic efficacy of artificial skin produced by 3D bioprinting Materials14 5177
[235] [235] Wang W Q, Meng Q Y, Li Q, Liu J B, Zhou M, Jin Z and Zhao K 2020 Chitosan derivatives and their application in biomedicine Int. J. Mol. Sci.21 487
[236] [236] Xia Y D, Wang D X, Liu D, Su J Y, Jin Y, Wang D, Han B B, Jiang Z P and Liu B 2022 Applications of chitosan and its derivatives in skin and soft tissue diseases Front. Bioeng. Biotechnol.10 894667
[237] [237] Feng P P, Luo Y, Ke C H, Qiu H F, Wang W, Zhu Y B, Hou R X, Xu L and Wu S Z 2021 Chitosan-based functional materials for skin wound repair: mechanisms and applications Front. Bioeng. Biotechnol.9 650598
[238] [238] Hafezi F, Shorter S, Tabriz A G, Hurt A, Elmes V, Boateng J and Douroumis D 2020 Bioprinting and preliminary testing of highly reproducible novel bioink for potential skin regeneration Pharmaceutics12 550
[239] [239] Zhu M, Hu T, Song W, Cui X L, Tian Y, Yao B, Wu M, Huang S and Niu Z W 2023 Guanidinylated/PEGylated chitosan in the bioink promotes the formation of multi-layered keratinocytes in a human skin equivalent Carbohydr. Polym.314 120964
[240] [240] Shaikh F M, Callanan A, Kavanagh E G, Burke P E, Grace P A and McGloughlin T M 2008 Fibrin: a natural biodegradable scaffold in vascular tissue engineering Cells Tissues Organs188 333–346
[241] [241] Kita R, Takahashi A, Kaibara M and Kubota K 2002 Formation of fibrin gel in fibrinogen-thrombin system: static and dynamic light scattering study Biomacromolecules3 1013–1020
[242] [242] Larsson U 1988 Polymerization and gelation of fibronogen in D2O Eur. J. Biochem.174 139–144
[243] [243] Mobaraki M, Ghaffari M, Yazdanpanah A, Luo Y Y and Mills D K 2020 Bioinks and bioprinting: a focused review Bioprinting18 e00080
[244] [244] Babu S, Albertino F, Anarkoli A O and De Laporte L 2021 Controlling structure with injectable biomaterials to better mimic tissue heterogeneity and anisotropy Adv. Healthcare Mater.10 2002221
[245] [245] Shpichka A et al 2020 Fibrin-based bioinks: new tricks from an old dog Int. J. Bioprinting6 269
[246] [246] Hoppenbrouwers T, Tuk B, Fijneman E M G, de Maat M P M and van Neck J W 2017 Fibrin improves skin wound perfusion in a diabetic rat model Thromb. Res.151 36–40
[247] [247] Bacakova M, Musilkova J, Riedel T, Stranska D, Brynda E, Bacakova L and Zaloudkova M 2016 The potential applications of fibrin-coated electrospun polylactide nanofibers in skin tissue engineering Int. J. Nanomed.11 771–789
[248] [248] Horch R E, Bannasch H and Stark G B 2001 Transplantation of cultured autologous keratinocytes in fibrin sealant biomatrix to resurface chronic wounds Transplant. Proc.33 642–644
[249] [249] Cavallo A, Al Kayal T, Mero A, Mezzetta A, Guazzelli L, Soldani G and Losi P 2023 Fibrinogen-based bioink for application in skin equivalent 3D bioprinting J. Funct. Biomater.14 459
[250] [250] Mazlyzam A L, Aminuddin B S, Fuzina N H, Norhayati M M, Fauziah O, Isa M R, Saim L and Ruszymah B H I 2007 Reconstruction of living bilayer human skin equivalent utilizing human fibrin as a scaffold Burns33 355–63
[251] [251] Petta D, D'Amora U, Ambrosio L, Grijpma D W, Eglin D and D'Este M 2020 Hyaluronic acid as a bioink for extrusion-based 3D printing Biofabrication12 032001
[252] [252] Gopinathan J and Noh I 2018 Recent trends in bioinks for 3D printing Biomater. Res.22 11
[253] [253] Si H P, Xing T L, Ding Y L, Zhang H B, Yin R X and Zhang W J 2019 3D bioprinting of the sustained drug release wound dressing with double-crosslinked hyaluronic-acid-based hydrogels Polymers11 1584
[254] [254] Bavaresco B, Comn R, Salvatierra N A and Cid M P 2020 Three-dimensional printing of collagen and hyaluronic acid scaffolds with dehydrothermal treatment crosslinking Compos. Commun.19 1–5
[255] [255] Zhou Y, Fan Y C, Chen Z, Yue Z L and Wallace G 2022 Catechol functionalized ink system and thrombin-free fibrin gel for fabricating cellular constructs with mechanical support and inner micro channels Biofabrication14 015004
[256] [256] Thakur B R, Singh R K, Handa A K and Rao M A 1997 Chemistry and uses of pectin—a review Crit. Rev. Food Sci. Nutr.37 47–73
[257] [257] Suntornnond R, An J and Chua C K 2017 Bioprinting of thermoresponsive hydrogels for next generation tissue engineering: a review Macromol. Mater. Eng.302 1600266
[258] [258] Pereira R F, Sousa A, Barrias C C, Brtolo P J and Granja P L 2018 A single-component hydrogel bioink for bioprinting of bioengineered 3D constructs for dermal tissue engineering Mater. Horiz.5 1100–1111
[259] [259] Ridley B L, O'Neill M A and Mohnen D 2001 Pectins: structure, biosynthesis, and oligogalacturonide-related signaling Phytochemistry57 929–67
[260] [260] Pereira R F, Barrias C C, Brtolo P J and Granja P L 2018 Cell-instructive pectin hydrogels crosslinked via thiol-norbornene photo-click chemistry for skin tissue engineering Acta Biomater.66 282–293
[261] [261] Juregui K M G, Cabrera J C C, Ceniceros E P S, Hernndez J L M and Ilyina A 2009 A new formulated stable papin-pectin aerosol spray for skin wound healing Biotechnol. Bioprocess Eng.14 450–456
[262] [262] Trkkan S, Atila D, Akda A and Tezcaner A 2018 Fabrication of functionalized citrus pectin/silk fibroin scaffolds for skin tissue engineering J. Biomed. Mater. Res. B 106 2625–2635
[263] [263] Hospodiuk M, Dey M, Sosnoski D and Ozbolat I T 2017 The bioink: a comprehensive review on bioprintable materials Biotechnol. Adv.35 217–239
[264] [264] Lee K Y and Mooney D J 2012 Alginate: properties and biomedical applications Prog. Polym. Sci.37 106–126
[265] [265] Ramakrishnan R, Kasoju N, Raju R, Geevarghese R, Gauthaman A and Bhatt A 2022 Exploring the potential of alginate-gelatin-diethylaminoethyl cellulose-fibrinogen based bioink for 3D bioprinting of skin tissue constructs Carbohydr. Polym. Technol. Appl.3 100184
[266] [266] Rezvanian M, Amin M C I M and Ng SF 2016 Development and physicochemical characterization of alginate composite film loaded with simvastatin as a potential wound dressing Carbohydrate Polym.137 295–304
[267] [267] Cheng L H H et al 2019 Properties of an alginate-gelatin-based bioink and its potential impact on cell migration, proliferation, and differentiation Int. J. Biol. Macromol.135 1107–1113
[268] [268] Hashimoto T, Suzuki Y, Tanihara M, Kakimaru Y and Suzuki K 2004 Development of alginate wound dressings linked with hybrid peptides derived from laminin and elastin Biomaterials25 1407–1414
[269] [269] Millar S E 2002 Molecular mechanisms regulating hair follicle development J. Invest. Dermatol.118 216–225
[270] [270] Cotsarelis G 2006 Epithelial stem cells: a folliculocentric view J. Invest. Dermatol.126 1459–1468
[271] [271] Madaan A, Verma R, Singh A T and Jaggi M 2018 Review of hair follicle dermal papilla cells as in vitro screening model for hair growth Int. J. Cosmet. Sci.40 429–50
[272] [272] Delevoye C 2014 Melanin transfer: the keratinocytes are more than gluttons J. Invest. Dermatol.134 877–9
[273] [273] Swope V B, Supp A P and Boyce S T 2002 Regulation of cutaneous pigmentation by titration of human melanocytes in cultured skin substitutes grafted to athymic mice Wound Repair. Regener.10 378–86
[274] [274] Lee A Y, Kim J Y, Park C D, Lee J H, Lee C H and Do A Y 2012 Co-culture of melanocytes with adipose-derived stem cells as a potential substitute for co-culture with keratinocytes Acta Derm. Venereol.92 16–23
[275] [275] Has C and Nystrm A 2015 Epidermal basement membrane in health and disease Curr. Top. Membr.76 117–70
[276] [276] Amano S 2016 Characterization and mechanisms of photoageing-related changes in skin. Damages of basement membrane and dermal structures Exp. Dermatol.25 14–19
[277] [277] Weinberg W C, Goodman L V, George C, Morgan D L, Ledbetter S, Yuspa S H and Lichti U 1993 Reconstitution of hair follicle development in vivo: determination of follicle formation, hair growth, and hair quality by dermal cells J. Invest. Dermatol.100 229–36
[278] [278] Lee J, Bscke R, Tang PC, Hartman B H, Heller S and Koehler K R 2018 Hair follicle development in mouse pluripotent stem cell-derived skin organoids Cell Rep.22 242–254
[279] [279] Jeong S, Na Y, Nam HM and Sung G Y 2023 Skin-on-a-chip strategies for human hair follicle regeneration Exp. Dermatol.32 13–23
[280] [280] Aoki H, Hara A, Motohashi T, Osawa M and Kunisada T 2011 Functionally distinct melanocyte populations revealed by reconstitution of hair follicles in mice Pigm. Cell Melanoma Res.24 125–35
[281] [281] Xiao SE, Miao Y, Wang J, Jiang W, Fan ZX, Liu XM and Hu ZQ 2017 As a carrier-transporter for hair follicle reconstitution, platelet-rich plasma promotes proliferation and induction of mouse dermal papilla cells Sci. Rep.7 1125
[282] [282] Liang Y H, Silva K A, Kennedy V and Sundberg J P 2011 Comparisons of mouse models for hair follicle reconstitution Exp. Dermatol.20 1011–5
[283] [283] Abaci H E, Coffman A, Doucet Y, Chen J, Jackw J, Wang E, Guo Z Y, Shin J U, Jahoda C A and Christiano A M 2018 Tissue engineering of human hair follicles using a biomimetic developmental approach Nat. Commun.9 5301
[284] [284] Zhao W X, Chen H Y, Zhang Y, Zhou D Z, Liang L, Liu B X and Xu T 2022 Adaptive multi-degree-of-freedom in situ bioprinting robot for hair-follicle-inclusive skin repair: a preliminary study conducted in mice Bioeng. Transl. Med.7 e10303
[285] [285] Chen H Y, Zhang Y, Zhou D Z, Ma X X, Yang S M and Xu T 2022 Mechanical engineering of hair follicle regeneration by in situ bioprinting Biomater. Adv.142 213127
[286] [286] Nanmo A, Yan L, Asaba T, Wan L C, Kageyama T and Fukuda J 2023 Bioprinting of hair follicle germs for hair regenerative medicine Acta Biomater.165 50–59
[287] [287] Kang D N et al 2023 3D bioprinting of a gelatin-alginate hydrogel for tissue-engineered hair follicle regeneration Acta Biomater.165 19–30
[288] [288] Catarino C M, Schuck D C, Dechiario L and Karande P 2023 Incorporation of hair follicles in 3D bioprinted models of human skin Sci. Adv.9 eadg0297
[289] [289] Huang S, Wiszniewski L and Constant S 2011 The use of in vitro 3D cell models in drug development for respiratory diseases Drug Discovery and Development—Present and Future ed I M Kapetanovi (InTech) pp 169–90
[290] [290] Liu N B, Huang S, Yao B, Xie J F, Wu X and Fu X B 2016 3D bioprinting matrices with controlled pore structure and release function guide in vitro self-organization of sweat gland Sci. Rep.6 34410
[291] [291] Wang R et al 2019 Redirecting differentiation of mammary progenitor cells by 3D bioprinted sweat gland microenvironment Burns Trauma7 29
[292] [292] Zhang Y J et al 2021 Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles Burns Trauma9 tkab013
[293] [293] Tarassoli S P, Jessop Z M, Al-Sabah A, Gao N, Whitaker S, Doak S and Whitaker I S 2018 Skin tissue engineering using 3D bioprinting: an evolving research field J. Plast. Reconstr. Aesthet. Surg.71 615–623
[294] [294] Velasquillo C, Galue E A, Rodriquez L, Ibarra C and Ibarra-Ibarra L G 2013 Skin 3D bioprinting. applications in cosmetology J. Cosmet. Dermatol. Sci. Appl.3 85–89
[295] [295] Olejnik A, Semba J A, Kulpa A, Daczak-Pazdrowska A, Rybka J D and Gornowicz-Porowska J 2022 3D bioprinting in skin related research: recent achievements and application perspectives ACS Synth. Biol.11 26–38
[296] [296] Li L, Fukunaga-Kalabis M, Yu H, Xu X W, Kong J, Lee J T and Herlyn M 2010 Human dermal stem cells differentiate into functional epidermal melanocytes J. Cell Sci.123 853–60
[297] [297] Li L, Fukunaga-Kalabis M and Herlyn M 2011 The three-dimensional human skin reconstruct model: a tool to study normal skin and melanoma progression J. Vis. Exp.3 2937
[298] [298] Duval C, Chagnoleau C, Pouradier F, Sextius P, Condom E and Bernerd F 2012 Human skin model containing melanocytes: essential role of keratinocyte growth factor for constitutive pigmentation-functional response to -melanocyte stimulating hormone and forskolin Tissue Eng. C 18 947–57
[299] [299] Dinella J, Koster M I and Koch P J 2014 Use of induced pluripotent stem cells in dermatological research J. Invest. Dermatol.134 1–5
[300] [300] Bilousova G and Roop D R 2014 Induced pluripotent stem cells in dermatology: potentials, advances, and limitations Cold Spring Harb. Perspect. Med.4 a015164
[301] [301] Itoh M, Kiuru M, Cairo M S and Christiano A M 2011 Generation of keratinocytes from normal and recessive dystrophic epidermolysis bullosa-induced pluripotent stem cells Proc. Natl Acad. Sci. USA108 8797–8802
[302] [302] Itoh M, Umegaki-Arao N, Guo Z Y, Liu L, Higgins C A, Christiano A M and Eckert R 2013 Generation of 3D skin equivalents fully reconstituted from human induced pluripotent stem cells (iPSCs) PLoS One8 e77673
[303] [303] Muller Q, Beaudet MJ, De Serres-brard T, Bellenfant S, Flacher V and Berthod F 2018 Development of an innervated tissue-engineered skin with human sensory neurons and Schwann cells differentiated from iPS cells Acta Biomater.82 93–101
[304] [304] Guo Z Y et al 2021 Engineering human skin model innervated with itch sensory neuron-like cells differentiated from induced pluripotent stem cells Bioeng. Transl. Med.7 e10247
[305] [305] Pappalardo A, Herron L, Cespedes D E A and Abaci H E 2021 Quantitative evaluation of human umbilical vein and induced pluripotent stem cell-derived endothelial cells as an alternative cell source to skin-specific endothelial cells in engineered skin grafts Adv. Wound Care10 490–502
[306] [306] Bezenah J R, Rioja A Y, Juliar B, Friend N and Putnam A J 2019 Assessing the ability of human endothelial cells derived from induced-pluripotent stem cells to form functional microvasculature in vivo Biotechnol. Bioeng.116 415–26
[307] [307] Abaci H E, Guo Z Y, Coffman A, Gillette B, Lee WH, Sia S K and Christiano A M 2016 Human skin constructs with spatially controlled vasculature using primary and iPSC-derived endothelial cells Adv. Healthcare Mater.5 1800–7
[308] [308] Hafner AL et al 2016 Brown-like adipose progenitors derived from human induced pluripotent stem cells: identification of critical pathways governing their adipogenic capacity Sci. Rep.6 32490
[309] [309] Ahfeldt T et al 2012 Programming human pluripotent stem cells into white and brown adipocytes Nat. Cell Biol.14 209–19
[310] [310] Bernareggi D, Pouyanfard S and Kaufman D S 2019 Development of innate immune cells from human pluripotent stem cells Exp. Hematol.71 13–23
[311] [311] Nianias A and Themeli M 2019 Induced pluripotent stem cell (iPSC)–derived lymphocytes for adoptive cell immunotherapy: recent advances and challenges Curr. Hematol. Malig. Rep.14 261–8
[312] [312] Jackw J et al 2019 CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells Proc. Natl Acad. Sci. USA116 26846–52
[313] [313] Lee J, van der Valk W H, Serdy S A, Deakin C C, Kim J, Le A P and Koehler K R 2022 Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells Nat. Protocols17 1266–1305
[314] [314] Hong ZX, Zhu ST, Li H, Luo JZ, Yang Y, An Y, Wang X and Wang K 2023 Bioengineered skin organoids: from development to applications Mil. Med. Res.10 40
[315] [315] Nguyen D et al 2017 Cartilage tissue engineering by the 3D bioprinting of iPS cells in a nanocellulose/alginate bioink Sci. Rep.7 658
[316] [316] Koch L, Deiwick A, Franke A, Schwanke K, Haverich A, Zweigerdt R and Chichkov B 2018 Laser bioprinting of human induced pluripotent stem cells—the effect of printing and biomaterials on cell survival, pluripotency, and differentiation Biofabrication10 035005
[317] [317] Gu Q, Tomaskovic-Crook E, Wallace G G and Crook J M 2017 3D bioprinting human induced pluripotent stem cell constructs for in situ cell proliferation and successive multilineage differentiation Adv. Healthcare Mater.6 1700175
[318] [318] Ji W Q, Hou B, Lin W G, Wang L L, Zheng W H, Li W D, Zheng J, Wen X J and He P 2020 3D bioprinting a human iPSC-derived MSC-loaded scaffold for repair of the uterine endometrium Acta Biomater.116 268–284
[319] [319] Lin W M, Chen M, Hu C, Qin S Y, Chu C Y, Xiang L, Man Y and Qu Y L 2018 Endowing iPSC-derived MSCs with angiogenic and keratinogenic differentiation potential: a promising cell source for skin tissue engineering BioMed Res. Int.2018 8459503
[320] [320] Arai K, Murata D, Verissimo A R, Mukae Y, Itoh M, Nakamura A, Morita S, Nakayama K and Matsusaki M 2018 Fabrication of scaffold-free tubular cardiac constructs using a Bio-3D printer PLoS One13 e0209162
[321] [321] Ma X Y et al 2016 Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting Proc. Natl Acad. Sci. USA113 2206–2211
[322] [322] Soman S S and Vijayavenkataraman S 2020 Applications of 3D bioprinted-induced pluripotent stem cells in healthcare Int. J. Bioprinting6 280
[323] [323] Shahin H, Elmasry M, Steinvall I, Sberg F and El-Serafi A 2020 Vascularization is the next challenge for skin tissue engineering as a solution for burn management Burns Trauma8 tkaa022
[324] [324] Cui H T, Nowicki M, Fisher J P and Zhang L G 2017 3D bioprinting for organ regeneration Adv. Healthcare Mater.6 1601118
[325] [325] Chen E P, Toksoy Z, Davis B A and Geibel J P 2021 3D bioprinting of vascularized tissues for in vitro and in vivo applications Front. Bioeng. Biotechnol.9 664188
[326] [326] Hauser P V, Chang HM, Nishikawa M, Kimura H, Yanagawa N and Hamon M 2021 Bioprinting scaffolds for vascular tissues and tissue vascularization Bioengineering8 178
[327] [327] Tripathi S, Mandal S S, Bauri S and Maiti P 2023 3D bioprinting and its innovative approach for biomedical applications MedComm4 e194
[328] [328] Joshi A, Choudhury S, Gugulothu S B, Visweswariah S S and Chatterjee K 2022 Strategies to promote vascularization in 3D printed tissue scaffolds: trends and challenges Biomacromolecules23 2730–51
[329] [329] Spter T, Ampofo E, Menger M D and Laschke M W 2020 Combining vascularization strategies in tissue engineering: the faster road to success? Front. Bioeng. Biotechnol.8 592095
[330] [330] Frueh F S, Menger M D, Lindenblatt N, Giovanoli P and Laschke M W 2017 Current and emerging vascularization strategies in skin tissue engineering Crit. Rev. Biotechnol.37 613–25
[331] [331] Kim B S, Ahn M, Cho WW, Gao G, Jang J and Cho DW 2021 Engineering of diseased human skin equivalent using 3D cell printing for representing pathophysiological hallmarks of type 2 diabetes in vitro Biomaterials272 120776
[332] [332] Dai LG, Dai NT, Chen TY, Kang LY and Hsu SH 2022 A bioprinted vascularized skin substitute with fibroblasts, keratinocytes, and endothelial progenitor cells for skin wound healing Bioprinting28 e00237
[333] [333] Kim B S, Kwon Y W, Kong JS, Park G T, Gao G, Han W, Kim MB, Lee H, Kim J H and Cho DW 2018 3D cell printing of in vitro stabilized skin model and in vivo pre-vascularized skin patch using tissue-specific extracellular matrix bioink: a step towards advanced skin tissue engineering Biomaterials168 38–53
[334] [334] Rimal R et al 2021 Dynamic flow enables long-term maintenance of 3-D vascularized human skin models Appl. Mater. Today25 101213
[335] [335] Baltazar T, Jiang B, Moncayo A, Merola J, Albanna M Z, Saltzman W M and Pober J S 2022 3D bioprinting of an implantable xeno-free vascularized human skin graft Bioeng. Transl. Med.8 e10324
[336] [336] Oliveira H, Mdina C, Labrunie G, Dusserre N, Catros S, Magnan L, Handschin C, Stachowicz M L, Fricain JC and L'Heureux N 2022 Cell-assembled extracellular matrix (CAM): a human biopaper for the biofabrication of pre-vascularized tissues able to connect to the host circulation in vivo Biofabrication14 015005
[337] [337] Karande P, Baltazar T, Merola J and Catarino C 2020 Breaking barriers—printing vascularized skin (Rensselaer Polytechnic Institute)
[338] [338] Phua Q H, Han H A and Soh BS 2021 Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration J. Transl. Med.19 83
[339] [339] Yang R H, Yang S, Zhao J L, Hu X M, Chen X D, Wang J R, Xie J L and Xiong K 2020 Progress in studies of epidermal stem cells and their application in skin tissue engineering Stem Cell Res. Ther.11 303
[340] [340] Wang R, Wang Y H, Yao B, Hu T, Li Z, Huang S and Fu X B 2019 Beyond 2D: 3D bioprinting for skin regeneration Int. Wound J.16 134–138
[341] [341] Oualla-Bachiri W, Fernndez-Gonzlez A, Quiones-Vico M I and Arias-Santiago S 2020 From grafts to human bioengineered vascularized skin substitutes Int. J. Mol. Sci.21 8197
[342] [342] Pirayesh A, Hoeksema H, Richters C, Verbelen J and Monstrey S 2015 Glyaderm® dermal substitute: clinical application and long-term results in 55 patients Burns41 132–144
[343] [343] Shahrokhi S, Arno A and Jeschke M G 2014 The use of dermal substitutes in burn surgery: acute phase Wound Repair. Regener.22 14–22
[344] [344] Ho J K, Shao H W, You C G, Pan X L, Wang X G, Chen G X, Khan A and Han C M 2019 Successful application of tissue engineering skin to third degree burn wound on lateral thorax: a case study Biomed. J. Sci. Tech. Res.16 12122–5
[345] [345] Demircan M, Cicek T and Yetis M I 2015 Preliminary results in single-step wound closure procedure of full-thickness facial burns in children by using the collagen-elastin matrix and review of pediatric facial burns Burns41 1268–1274
[346] [346] Liu J, Zhou Z T, Zhang M, Song F, Feng C and Liu H C 2022 Simple and robust 3D bioprinting of full-thickness human skin tissue Bioengineered13 10090–100
[347] [347] Baltazar T et al 2020 Three dimensional bioprinting of a vascularized and perfusable skin graft using human keratinocytes, fibroblasts, pericytes, and endothelial cells Tissue Eng. A 26 227–38
[348] [348] Gore D C 1997 Outcome and cost analysis for outpatient skin grafting J. Trauma43 597–600
[349] [349] Pearce F B and Richardson K A 2017 Negative pressure wound therapy, staged excision and definitive closure with split-thickness skin graft for axillary hidradenitis suppurativa: a retrospective study J. Wound Care26 S36–S42
[350] [350] Mills A, Lago J, Vasquez-Pinto L, Massaguer P and Maria-Engler S S 2019 Approaches to the development of 3D bioprinted skin models: the case of natura cosmetics Int. J. Adv. Med. Biotechnol.2 3–13
[351] [351] Sarkiri M, Fox S C, Fratila-Apachitei L E and Zadpoor A A 2019 Bioengineered skin intended for skin disease modeling Int. J. Mol. Sci.20 1407
[352] [352] Vijayavenkataraman S 2017 3D bioprinted skin: the first ‘to-be' successful printed organ? J. 3D Print. Med.1 143–4
[353] [353] Sekar M P, Budharaju H, Zennifer A, Sethuraman S, Vermeulen N, Sundaramurthi D and Kalaskar D M 2021 Current standards and ethical landscape of engineered tissues—3D bioprinting perspective J. Tissue Eng.12 20417314211027677
[354] [354] Ramadan Q and Zourob M 2021 3D bioprinting at the frontier of regenerative medicine, pharmaceutical, and food industries Front. Med. Technol.2 607648
[355] [355] Jovic T H, Combellack E J, Jessop Z M and Whitaker I S 2020 3D bioprinting and the future of surgery Front. Surg.7 609836
[356] [356] Varkey M and Atala A 2015 Organ bioprinting: a closer look at ethics and policies Wake Forest J. Law Policy5 275 (available at: www.researchgate.net/publication/281639838_Organ_Bioprinting_A_Closer_Look_at_Ethics_and_Policies)
[357] [357] FDA 2016 Technical considerations for additive manufactured devices draft guidance for industry and food and drug administration staff (available at: www.fda.gov/regulatory-information/search-fda-guidance-documents/technical-considerations-additive-manufactured-medical-devices)
[358] [358] Mullins E et al 2022 Scientific opinion on development needs for the allergenicity and protein safety assessment of food and feed products derived from biotechnology EFSA J.20 e07044
[359] [359] Lorenz A, Raven M and Blind K 2019 The role of standardization at the interface of product and process development in biotechnology J. Technol. Transfer44 1097–1133
[360] [360] Fogel D B 2018 Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: a review Contemp. Clin. Trials Commun.11 156–64
[361] [361] Liu X, Michael S, Bharti K, Ferrer M and Song M J 2020 A biofabricated vascularized skin model of atopic dermatitis for preclinical studies Biofabrication12 035002
[362] [362] Lgues M, Milet C, Forraz N, Berthelemy N, Pain S, Andr-Frei V, Cadau S and Mcguckin C 2020 The world's first 3D bioprinted immune skin model suitable for screening drugs and ingredients for normal and inflamed skin IFSCC Magazine vol 23 pp 233–9
[363] [363] de Andrs J L, Ruiz-Toranzo M, Antich C, Chocarro-Wrona C, Lpez-Ruz E, Jimnez G and Marchal J A 2023 Biofabrication of a tri-layered 3D-bioprinted CSC-based malignant melanoma model for personalized cancer treatment Biofabrication15 035016
[364] [364] Browning J R et al 2020 A 3D biofabricated cutaneous squamous cell carcinoma tissue model with multi-channel confocal microscopy imaging biomarkers to quantify antitumor effects of chemotherapeutics in tissue Oncotarget11 2587–96
[365] [365] Duan J H, Cao Y Y, Shen Z Z, Cheng Y Q, Ma Z W, Wang L J, Zhang Y T, An Y C and Sang S B 2022 3D bioprinted GelMA/PEGDA hybrid scaffold for establishing an in vitro model of melanoma J. Microbiol. Biotechnol.32 531–40
[366] [366] Larson P J, Chong D, Fleming E and Oh J 2021 Challenges in developing a human model system for skin microbiome research J. Invest. Dermatol.141 228–31.e4
[367] [367] Yin Z, Guo H, Li Y X, Chiu J and Tian L M 2020 Ultrastable plasmonic bioink for printable point-of-care biosensors ACS Appl. Mater. Interfaces12 35977–85
[368] [368] Mohanty S P and Kougianos E 2006 Biosensors: a tutorial review IEEE Potentials25 35–40
[369] [369] Singh A K, Mittal S, Das M, Saharia A and Tiwari M 2023 Optical biosensors: a decade in review Alex. Eng. J.67 673–91
[370] [370] Yuqing M, Jianguo J G and Jianrong C 2003 Ion sensitive field effect transducer-based biosensors Biotechnol. Adv.21 527–34
[371] [371] Youssef K, Ullah A, Rezai P, Hasan A and Amirfazli A 2023 Recent advances in biosensors for real time monitoring of pH, temperature, and oxygen in chronic wounds Mater. Today Bio22 100764
[372] [372] Kim J, Campbell A S, de vila B E F and Wang J 2019 Wearable biosensors for healthcare monitoring Nat. Biotechnol.37 389–406
[373] [373] Salvo P, Dini V, Kirchhain A, Janowska A, Oranges T, Chiricozzi A, Lomonaco T, Di Francesco F and Romanelli M 2017 Sensors and biosensors for C-reactive protein, temperature and pH, and their applications for monitoring wound healing: a review Sensors17 2952
[374] [374] Starly B and Choubey A 2008 Enabling sensor technologies for the quantitative evaluation of engineered tissue Ann. Biomed. Eng.36 30–40
[375] [375] Goode J A, Rushworth J V H and Millner P A 2015 Biosensor regeneration: a review of common techniques and outcomes Langmuir31 6267–6276
[376] [376] Van De Ven M 2014 Chronic wound healing and woundbed-biofilm interactions in silico Biophys. J.106 579A
[377] [377] Goto T and Saligan L N 2020 Wound pain and wound healing biomarkers from wound exudate: a scoping review J. Wound Ostomy Continence Nurs.47 559–68
[378] [378] Gao Y J et al 2021 A flexible multiplexed immunosensor for point-of-care in situ wound monitoring Sci. Adv.7 eabg9614
[379] [379] Mertz P M and Ovington L G 1993 Wound healing microbiology Dermatol. Clin.11 739–47
[380] [380] Jones E M, Cochrane C A and Percival S L 2015 The effect of pH on the extracellular matrix and biofilms Adv. Wound Care4 431–9
[381] [381] Dargaville T R, Farrugia B L, Broadbent J A, Pace S, Upton Z and Voelcker N H 2013 Sensors and imaging for wound healing: a review Biosens. Bioelectron.41 30–42
[382] [382] Jankowska D A, Bannwarth M B, Schulenburg C, Faccio G, Maniura-Weber K, Rossi R M, Scherer L, Richter M and Boesel L F 2017 Simultaneous detection of pH value and glucose concentrations for wound monitoring applications Biosens. Bioelectron.87 312–9
[383] [383] Ashley B K, Brown M S, Park Y, Kuan S and Koh A 2019 Skin-inspired, open mesh electrochemical sensors for lactate and oxygen monitoring Biosens. Bioelectron.132 343–51
[384] [384] Xia J F and Sonkusale S 2021 Flexible thread-based electrochemical sensors for oxygen monitoring Analyst146 2983–90
[385] [385] Nyein H Y Y et al 2016 A wearable electrochemical platform for noninvasive simultaneous monitoring of Ca2+ and pH ACS Nano10 7216–24
[386] [386] Nothdurfter D, Ploner C, Coraa-Huber D C, Wilflingseder D, Mller T, Hermann M, Hagenbuchner J and Ausserlechner M J 2022 3D bioprinted, vascularized neuroblastoma tumor environment in fluidic chip devices for precision medicine drug testing Biofabrication14 035002
[387] [387] Patra S and Young V 2016 A review of 3D printing techniques and the future in biofabrication of bioprinted tissue Cell Biochem. Biophys.74 93–98
[388] [388] Hendrickx B, Vranckx J J and Luttun A 2011 Cell-based vascularization strategies for skin tissue engineering Tissue Eng. B 17 13–24
[389] [389] Haleem A, Javaid M, Singh R P, Suman R and Rab S 2021 Biosensors applications in medical field: a brief review Sens. Int.2 100100
[390] [390] Bhatia D, Paul S, Acharjee T and Ramachairy S S 2024 Biosensors and their widespread impact on human health Sens. Int.5 100257
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Derman I Deniz, Rivera Taino, Cerda Laura Garriga, Singh Yogendra Pratap, Saini Shweta, Abaci Hasan Erbil, Ozbolat Ibrahim T. Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration[J]. International Journal of Extreme Manufacturing, 2025, 7(1): 12009
Category: Topical Review
Received: Feb. 27, 2024
Accepted: Apr. 17, 2025
Published Online: Apr. 17, 2025
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