International Journal of Extreme Manufacturing, Volume. 7, Issue 1, 12009(2025)

Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration

Derman I Deniz, Rivera Taino, Cerda Laura Garriga, Singh Yogendra Pratap, Saini Shweta, Abaci Hasan Erbil, and Ozbolat Ibrahim T

This comprehensive review explores the multifaceted landscape of skin bioprinting, revolutionizing dermatological research. The applications of skin bioprinting utilizing techniques like extrusion-, droplet-, laser- and light-based methods, with specialized bioinks for skin biofabrication have been critically reviewed along with the intricate aspects of bioprinting hair follicles, sweat glands, and achieving skin pigmentation. Challenges remain with the need for vascularization, safety concerns, and the integration of automated processes for effective clinical translation. The review further investigates the incorporation of biosensor technologies, emphasizing their role in monitoring and enhancing the wound healing process. While highlighting the remarkable progress in the field, critical limitations and concerns are critically examined to provide a balanced perspective. This synthesis aims to guide scientists, engineers, and healthcare providers, fostering a deeper understanding of the current state, challenges, and future directions in skin bioprinting for transformative applications in tissue engineering and regenerative medicine.

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Derman I Deniz, Rivera Taino, Cerda Laura Garriga, Singh Yogendra Pratap, Saini Shweta, Abaci Hasan Erbil, Ozbolat Ibrahim T. Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration[J]. International Journal of Extreme Manufacturing, 2025, 7(1): 12009

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Paper Information

Category: Topical Review

Received: Feb. 27, 2024

Accepted: Apr. 17, 2025

Published Online: Apr. 17, 2025

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DOI:10.1088/2631-7990/ad878c

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